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The leukemic stem cell niche: current concepts and therapeutic opportunities.

The leukemic stem cell niche: current concepts and therapeutic opportunities.

http://www.wikidata.org/entity/Q37295129

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CRIF1 interacting with CDK2 regulates bone marrow microenvironment-induced G0/G1 arrest of leukemia cells Stem Cell Modeling of Core Binding Factor Acute Myeloid Leukemia Humanized hemato-lymphoid system mice How I treat pediatric acute myeloid leukemia High-Throughput Single-Cell Labeling (Hi-SCL) for RNA-Seq Using Drop-Based Microfluidics MEIS1-mediated transactivation of synaptotagmin-like 1 promotes CXCL12/CXCR4 signaling and leukemogenesis.Update on acute myeloid leukemia stem cells: New discoveries and therapeutic opportunities Concise Review: CXCR4/CXCL12 Signaling in Immature Hematopoiesis--Lessons From Pharmacological and Genetic Models Cancer stem cells in basic science and in translational oncology: can we translate into clinical application?Human TM9SF4 Is a New Gene Down-Regulated by Hypoxia and Involved in Cell Adhesion of Leukemic Cells TGF-β family signaling in stem cells Bone marrow stromal cells modulate mouse ENT1 activity and protect leukemia cells from cytarabine induced apoptosis Pronounced hypoxia in models of murine and human leukemia: high efficacy of hypoxia-activated prodrug PR-104 Quantifying adhesion mechanisms and dynamics of human hematopoietic stem and progenitor cells Human extramedullary bone marrow in mice: a novel in vivo model of genetically controlled hematopoietic microenvironment Low expression of Abelson interactor-1 is linked to acquired drug resistance in Bcr-Abl-induced leukemia.Aging of the microenvironment influences clonality in hematopoiesis.Angiocrine factors deployed by tumor vascular niche induce B cell lymphoma invasiveness and chemoresistance The hematopoietic stem cell niche.Qki deficiency maintains stemness of glioma stem cells in suboptimal environment by downregulating endolysosomal degradation.Evidence for organ-specific stem cell microenvironments The phosphatidylinositol 3-kinase/Akt/mTOR signaling network as a therapeutic target in acute myelogenous leukemia patients.Decreased SFRP2 expression is associated with intermediate and poor karyotypes in de novo acute myeloid leukemia Angiocrine factors from Akt-activated endothelial cells balance self-renewal and differentiation of haematopoietic stem cells.Contribution of an aged microenvironment to aging-associated myeloproliferative disease.Osteoblasts as leukemia-initiating cells.Hyaluronan inhibits postchemotherapy tumor regrowth in a colon carcinoma xenograft model.Cediranib/AZD2171 inhibits bone and brain metastasis in a preclinical model of advanced prostate cancer.Interleukin-18 produced by bone marrow-derived stromal cells supports T-cell acute leukaemia progression Modulating the stem cell niche for tissue regeneration.Integrins and bone metastasis: integrating tumor cell and stromal cell interactions.Notch1-induced T cell leukemia can be potentiated by microenvironmental cues in the spleen.Visualising the cross-level relationships between pathological and physiological processes and gene expression: analyses of haematological diseases Deficiency of lipid phosphatase SHIP enables long-term reconstitution of hematopoietic inductive bone marrow microenvironment.Biology, risk stratification, and therapy of pediatric acute leukemias: an update.Multiple drug resistance due to resistance to stem cells and stem cell treatment progress in cancer (Review).E- and p-selectins are essential for repopulation of chronic myelogenous and chronic eosinophilic leukemias in a scid mouse xenograft model Adaptation of leukemia cells to hypoxic condition through switching the energy metabolism or avoiding the oxidative stress The dominant negative β isoform of the glucocorticoid receptor is uniquely expressed in erythroid cells expanded from polycythemia vera patients.Differential niche and Wnt requirements during acute myeloid leukemia progression

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The leukemic stem cell niche: current concepts and therapeutic opportunities.

http://www.wikidata.org/entity/Q37295129

description

article científic

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article scientifique

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articolo scientifico

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artigo científico

@pt

bilimsel makale

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scientific article published on 28 April 2009

@en

vedecký článok

@sk

vetenskaplig artikel

@sv

videnskabelig artikel

@da

vědecký článek

@cs

name

The leukemic stem cell niche: current concepts and therapeutic opportunities.

@en

The leukemic stem cell niche: current concepts and therapeutic opportunities.

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type

label

The leukemic stem cell niche: current concepts and therapeutic opportunities.

@en

The leukemic stem cell niche: current concepts and therapeutic opportunities.

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prefLabel

The leukemic stem cell niche: current concepts and therapeutic opportunities.

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The leukemic stem cell niche: current concepts and therapeutic opportunities.

@nl

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The leukemic stem cell niche: current concepts and therapeutic opportunities.

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D Gary Gilliland

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David T Scadden

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Steven W Lane

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P2860

Illegitimate WNT signaling promotes proliferation of multiple myeloma cells

WHIM syndrome myelokathexis reproduced in the NOD/SCID mouse xenotransplant model engrafted with healthy human stem cells transduced with C-terminus-truncated CXCR4

Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell

A cell initiating human acute myeloid leukaemia after transplantation into SCID mice

Haematopoietic stem cell release is regulated by circadian oscillations

Modeling the initiation and progression of human acute leukemia in mice

Tie2/angiopoietin-1 signaling regulates hematopoietic stem cell quiescence in the bone marrow niche

Granulocyte-macrophage progenitors as candidate leukemic stem cells in blast-crisis CML

SLAM family receptors distinguish hematopoietic stem and progenitor cells and reveal endothelial niches for stem cells

Osteoblastic cells regulate the haematopoietic stem cell niche

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1150-1157

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10.1182/BLOOD-2009-01-202606

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