An integrative genomics approach identifies Hypoxia Inducible Factor-1 (HIF-1)-target genes that form the core response to hypoxia.
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On the origin of Tibetans and their genetic basis in adapting high-altitude environmentsTranscriptional evidence for the "Reverse Warburg Effect" in human breast cancer tumor stroma and metastasis: similarities with oxidative stress, inflammation, Alzheimer's disease, and "Neuron-Glia Metabolic Coupling"HECT and RING finger families of E3 ubiquitin ligases at a glanceMicroRNA-210: a unique and pleiotropic hypoxamirIdentification of Ror2 as a hypoxia-inducible factor target in von Hippel-Lindau-associated renal cell carcinomaSustained radiosensitization of hypoxic glioma cells after oxygen pretreatment in an animal model of glioblastoma and in vitro models of tumor hypoxia.The LINK-A lncRNA activates normoxic HIF1α signalling in triple-negative breast cancerREST is a hypoxia-responsive transcriptional repressorPropofol's effect on the sciatic nerve: Harmful or protective?Metabolic adaptation to chronic inhibition of mitochondrial protein synthesis in acute myeloid leukemia cellsTranscriptional regulation of the Menkes copper ATPase (Atp7a) gene by hypoxia-inducible factor (HIF2{alpha}) in intestinal epithelial cellsTranscription factors Sp1 and Hif2α mediate induction of the copper-transporting ATPase (Atp7a) gene in intestinal epithelial cells during hypoxiaBMPR2 is required for postimplantation uterine function and pregnancy maintenanceGenome sequencing of the perciform fish Larimichthys crocea provides insights into molecular and genetic mechanisms of stress adaptationGlucose-induced O₂ consumption activates hypoxia inducible factors 1 and 2 in rat insulin-secreting pancreatic beta-cellsNeuroglobin-deficiency exacerbates Hif1A and c-FOS response, but does not affect neuronal survival during severe hypoxia in vivoDaxx inhibits hypoxia-induced lung cancer cell metastasis by suppressing the HIF-1α/HDAC1/Slug axis.HIF-KDM3A-MMP12 regulatory circuit ensures trophoblast plasticity and placental adaptations to hypoxia.Validation of suitable house keeping genes for hypoxia-cultured human chondrocytes.Functional characterization of two CITED3 homologs (gcCITED3a and gcCITED3b) in the hypoxia-tolerant grass carp, Ctenopharyngodon idellus.Genome-wide identification of hypoxia-inducible factor binding sites and target genes by a probabilistic model integrating transcription-profiling data and in silico binding site prediction.Research resource: Transcriptional profiling reveals different pseudohypoxic signatures in SDHB and VHL-related pheochromocytomasProfilin-1 phosphorylation directs angiocrine expression and glioblastoma progression through HIF-1α accumulation.In vivo modulation of hypoxia-inducible signaling by topographical helix mimetics.Up-regulation of glycolytic metabolism is required for HIF1α-driven bone formationIn vitro downregulated hypoxia transcriptome is associated with poor prognosis in breast cancer.Rho-kinase inhibitor Y-27632 and hypoxia synergistically enhance chondrocytic phenotype and modify S100 protein profiles in human chondrosarcoma cells.Hypoxia is a Key Driver of Alternative Splicing in Human Breast Cancer Cells.The effects of CoCl2 on HIF-1α protein under experimental conditions of autoprogressive hypoxia using mouse models.Genome-wide association study for atopy and allergic rhinitis in a Singapore Chinese populationGlobal gene expression profiling in three tumor cell lines subjected to experimental cycling and chronic hypoxia.Identification of hypoxia-induced genes in human SGBS adipocytes by microarray analysis.Distinct microRNA expression signatures are associated with melanoma subtypes and are regulated by HIF1A.Respiratory complex I is essential to induce a Warburg profile in mitochondria-defective tumor cells.NAD+-dependent sirtuin 1 and 6 proteins coordinate a switch from glucose to fatty acid oxidation during the acute inflammatory response.Expression profiling reveals novel hypoxic biomarkers in peripheral blood of adult mice exposed to chronic hypoxia.Targeted genes and interacting proteins of hypoxia inducible factor-1.Intracellular pathogen Leishmania donovani activates hypoxia inducible factor-1 by dual mechanism for survival advantage within macrophage.TMEM45A is essential for hypoxia-induced chemoresistance in breast and liver cancer cellsGLUT-1 expression is largely unrelated to both hypoxia and the Warburg phenotype in squamous cell carcinomas of the vulva.
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An integrative genomics approach identifies Hypoxia Inducible Factor-1 (HIF-1)-target genes that form the core response to hypoxia.
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 02 June 2009
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
An integrative genomics approa ...... the core response to hypoxia.
@en
An integrative genomics approach identifies Hypoxia Inducible Factor-1
@nl
type
label
An integrative genomics approa ...... the core response to hypoxia.
@en
An integrative genomics approach identifies Hypoxia Inducible Factor-1
@nl
prefLabel
An integrative genomics approa ...... the core response to hypoxia.
@en
An integrative genomics approach identifies Hypoxia Inducible Factor-1
@nl
P2093
P2860
P356
P1476
An integrative genomics approa ...... m the core response to hypoxia
@en
P2093
Daniel C Chung
Hirotoshi Kikuchi
Michael Q Zhang
Ramnik J Xavier
Yair Benita
P2860
P304
P356
10.1093/NAR/GKP425
P407
P577
2009-06-02T00:00:00Z