The influence of neuroactive steroid lipophilicity on GABAA receptor modulation: evidence for a low-affinity interaction.
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Neurosteroids and their role in sex-specific epilepsiesDiverse voltage-sensitive dyes modulate GABAA receptor functionGanaxolone suppression of behavioral and electrographic seizures in the mouse amygdala kindling modelStructurally diverse amphiphiles exhibit biphasic modulation of GABAA receptors: similarities and differences with neurosteroid actions.Kinetic and structural determinants for GABA-A receptor potentiation by neuroactive steroids.11-trifluoromethyl-phenyldiazirinyl neurosteroid analogues: potent general anesthetics and photolabeling reagents for GABAA receptors.Hydrophobic anions potently and uncompetitively antagonize GABA(A) receptor function in the absence of a conventional binding sitePhosphatidylinositol 4,5-bisphosphate depletion fails to affect neurosteroid modulation of GABAA receptor function.An allosteric coagonist model for propofol effects on α1β2γ2L γ-aminobutyric acid type A receptors.Neurosteroid analogues. 17. Inverted binding orientations of androsterone enantiomers at the steroid potentiation site on γ-aminobutyric acid type A receptorsNeurosteroid effects at α4βδ GABAA receptors alter spatial learning and synaptic plasticity in CA1 hippocampus across the estrous cycle of the mouse.Role of anticonvulsant and antiepileptogenic neurosteroids in the pathophysiology and treatment of epilepsy.The neurosteroid allopregnanolone modulates specific functions in central and peripheral glial cells.Characteristics of concatemeric GABA(A) receptors containing α4/δ subunits expressed in Xenopus oocytes.Neuroendocrine aspects of catamenial epilepsyGIRK channel modulation by assembly with allosterically regulated RGS proteinsNeurosteroids, stress and depression: potential therapeutic opportunities.Neurosteroid Structure-Activity Relationships for Functional Activation of Extrasynaptic δGABA(A) Receptors.Role of hormones and neurosteroids in epileptogenesis.Neurosteroid interactions with synaptic and extrasynaptic GABA(A) receptors: regulation of subunit plasticity, phasic and tonic inhibition, and neuronal network excitability.A mechanism regulating G protein-coupled receptor signaling that requires cycles of protein palmitoylation and depalmitoylation.Neurosteroids are reduced in diabetic neuropathy and may be associated with the development of neuropathic pain.Cardioprotection Effects of Sevoflurane by Regulating the Pathway of Neuroactive Ligand-Receptor Interaction in Patients Undergoing Coronary Artery Bypass Graft Surgery.Neurosteroid analogues. 18. Structure-activity studies of ent-steroid potentiators of γ-aminobutyric acid type A receptors and comparison of their activities with those of alphaxalone and allopregnanolone.Neurosteroids for the potential protection of humans against organophosphate toxicity.Novel therapeutic approaches for disease-modification of epileptogenesis for curing epilepsy.The sticky issue of neurosteroids and GABA(A) receptors.Left-shifted nav channels in injured bilayer: primary targets for neuroprotective nav antagonists?A clickable neurosteroid photolabel reveals selective Golgi compartmentalization with preferential impact on proximal inhibitionAccess of inhibitory neurosteroids to the NMDA receptor.Mapping Two Neurosteroid Modulatory Sites in the Prototypic Pentameric Ligand Gated Ion Channel GLIC.Abnormal DNA methylation may contribute to the progression of osteosarcoma.
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The influence of neuroactive steroid lipophilicity on GABAA receptor modulation: evidence for a low-affinity interaction.
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article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 24 June 2009
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
The influence of neuroactive s ...... or a low-affinity interaction.
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The influence of neuroactive s ...... or a low-affinity interaction.
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type
label
The influence of neuroactive s ...... or a low-affinity interaction.
@en
The influence of neuroactive s ...... or a low-affinity interaction.
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prefLabel
The influence of neuroactive s ...... or a low-affinity interaction.
@en
The influence of neuroactive s ...... or a low-affinity interaction.
@nl
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P2860
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The influence of neuroactive s ...... or a low-affinity interaction.
@en
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Achintya K Bandyopadhyaya
Amanda Taylor
Charles F Zorumski
Cunde Wang
Douglas F Covey
Kathiresan Krishnan
Lawrence N Eisenman
Mariangela Chisari
Steven Mennerick
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P304
P356
10.1152/JN.00346.2009
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P577
2009-06-24T00:00:00Z