Renal fibrosis is attenuated by targeted disruption of KCa3.1 potassium channels. - Wikidata - wikimedia - TriplyDB

Renal fibrosis is attenuated by targeted disruption of KCa3.1 potassium channels.

Renal fibrosis is attenuated by targeted disruption of KCa3.1 potassium channels.

http://www.wikidata.org/entity/Q37305118

about

Experimental therapies and ongoing clinical trials to slow down progression of ADPKD Novel roles for hERG K(+) channels in cell proliferation and apoptosis Novel phenolic inhibitors of small/intermediate-conductance Ca²⁺-activated K⁺ channels, KCa3.1 and KCa2.3 Using Visualized Matrix Effects to Develop and Improve LC-MS/MS Bioanalytical Methods, Taking TRAM-34 as an Example Advanced glycation end products promote proliferation of cardiac fibroblasts by upregulation of KCa3.1 channels Inhibition of the K+ channel K(Ca)3.1 reduces TGF-β1-induced premature senescence, myofibroblast phenotype transition and proliferation of mesangial cells.Ca(2+)-activated K(+) channel-3.1 blocker TRAM-34 attenuates airway remodeling and eosinophilia in a murine asthma model.Down-regulation of KCa2.3 channels causes erectile dysfunction in mice Treatment strategies and clinical trial design in ADPKD Epithelial Notch signaling regulates interstitial fibrosis development in the kidneys of mice and humans Increased constitutive αSMA and Smad2/3 expression in idiopathic pulmonary fibrosis myofibroblasts is KCa3.1-dependent.A novel pan-negative-gating modulator of KCa2/3 channels, fluoro-di-benzoate, RA-2, inhibits endothelium-derived hyperpolarization-type relaxation in coronary artery and produces bradycardia in vivo.Involvement of dominant-negative spliced variants of the intermediate conductance Ca2+-activated K+ channel, K(Ca)3.1, in immune function of lymphoid cells The Ca²⁺-activated K⁺ channel KCa3.1 as a potential new target for the prevention of allograft vasculopathy.The K+ channel KCa3.1 as a novel target for idiopathic pulmonary fibrosis IHG-1 promotes mitochondrial biogenesis by stabilizing PGC-1α.Fibrosis and progression of autosomal dominant polycystic kidney disease (ADPKD).Human lung myofibroblast TGFβ1-dependent Smad2/3 signalling is Ca(2+)-dependent and regulated by KCa3.1 K(+) channels Serum metabonomic analysis of protective effects of Curcuma aromatica oil on renal fibrosis rats.High expression of KCa3.1 in patients with clear cell renal carcinoma predicts high metastatic risk and poor survival.KCa3.1/IK1 Channel Regulation by cGMP-Dependent Protein Kinase (PKG) via Reactive Oxygen Species and CaMKII in Microglia: An Immune Modulating Feedback System?Modulation of K(Ca)3.1 channels by eicosanoids, omega-3 fatty acids, and molecular determinants Hydrogen Sulfide: A Therapeutic Candidate for Fibrotic Disease?The Lymphocyte Potassium Channels Kv1.3 and KCa3.1 as Targets for Immunosuppression.The Blockage of KCa3.1 Channel Inhibited Proliferation, Migration and Promoted Apoptosis of Human Hepatocellular Carcinoma Cells KCa3.1 K+ Channel Expression and Function in Human Bronchial Epithelial Cells Therapeutic potential of KCa3.1 blockers: recent advances and promising trends.KCa 3.1 channels maintain endothelium-dependent vasodilatation in isolated perfused kidneys of spontaneously hypertensive rats after chronic inhibition of NOS.Vascular KCa-channels as therapeutic targets in hypertension and restenosis disease.Identification of key metabolic changes in renal interstitial fibrosis rats using metabonomics and pharmacology.Blockade of KCa3.1 ameliorates renal fibrosis through the TGF-β1/Smad pathway in diabetic mice The potassium channel KCa3.1 as new therapeutic target for the prevention of obliterative airway disease.Development of a QPatch automated electrophysiology assay for identifying KCa3.1 inhibitors and activators.KCa3.1 mediates activation of fibroblasts in diabetic renal interstitial fibrosis.Evidence of K+ channel function in epithelial cell migration, proliferation, and repair.Intermediate-Conductance-Ca2-Activated K Channel IKCa1 Is Upregulated and Promotes Cell Proliferation in Cervical Cancer Oxidative stress in obstructive nephropathy.Endothelial small-conductance and intermediate-conductance KCa channels: an update on their pharmacology and usefulness as cardiovascular targets.Role of ion transport in control of apoptotic cell death.Cell proliferation, potassium channels, polyamines and their interactions: a mini review.

P2860

Q27001230-6C2C4975-C591-4A58-B414-385EDA4CDF33 Q27015660-54EB3EA2-A4BF-4D67-8565-EE68785DD6F3 Q28488052-EBD5DC36-86B1-44F9-AD40-E12968E0429C Q28546704-E6493BFD-D227-4065-B273-827C7577B704 Q28570112-EB6CCF05-D14C-411C-AFFD-F2BBC4F0A837 Q31149306-C1B4F4F9-AA9F-45B0-B439-0242EC8FCE3B Q33670161-145CA32C-F321-4385-9DCF-6DB1BD46BA1C Q33812566-F0E2E7A1-1B7E-4C1E-A5E8-864CC690B1EF Q34024396-6151555D-BA72-4F0D-9340-A5EEFB50836A Q34245363-1D603B2C-43A5-4915-8C69-773F79699F4D Q34677065-9C470FBB-C53C-463D-8A00-DE2E37298BC1 Q34946861-982EEA84-E1EC-480C-A20B-17B297B8D899 Q34947794-FE47D650-E586-4D92-80D6-C8A43B470D4D Q35060404-42CE3E95-E00D-43A9-9B93-7D2DD899F5B5 Q35083097-FBCB14CD-646D-4A96-902B-A0D259FFD65A Q35142716-E22BE5EE-B23E-4257-9BCD-F1085BBA0042 Q35194509-322670E0-E536-4BB0-9F33-1906FF7194AD Q35232951-9B6D2780-FA64-4AE8-A982-A53BE1FC4BD0 Q35284628-4FB280C4-18BB-4A09-8740-7176DE3AEF8C Q35304761-D8A8B6F2-A706-4A08-A4C8-7CC440664622 Q35316878-D9CE3D7E-2F39-4675-9E7A-EA3519CC6557 Q35395940-E51DEF55-72C9-4CF0-B45D-53CD26EF7BE3 Q35640718-AE3E9135-1F19-41FF-8960-376331E427CB Q35660234-8C240E02-9B85-48F1-871A-1606EA42E847 Q35739537-FC171871-D0C1-414D-962D-48F3ABA4085B Q35874185-DA1C3408-26F6-4A44-8305-284ADC806C7C Q35944615-F1DB0F6F-5CB3-4BE3-9724-BB93C15C9993 Q36619782-7A174D87-0ECA-4951-A5AA-90BBDF1A3B1D Q36815916-FC1BBE86-7F18-4880-98DB-E309215E8C91 Q36964810-659F6826-832D-424B-969F-08A07F68D213 Q37030987-573D187D-E814-4885-A4B1-70A83AB7B034 Q37184567-86E42687-1FAB-4F0B-B1F3-74E699B588DD Q37409003-DAC484BF-9757-44D2-A860-FCC15C1671A8 Q37542846-B1955144-23CE-44A1-AEF9-3A0A08FD3F09 Q37575263-C240688B-2C56-4E05-B9C4-EFE9B3C0D231 Q37712067-AA5C1588-2EF6-4269-8F76-21F3FCB581B3 Q37784045-5681560D-5DEA-4083-9FBF-DB40819EC31B Q38056312-3BA9B2C4-611B-454E-A7E3-F53A4130AC96 Q38110755-56894B11-EF12-487D-B3D0-82CFA28F8A05 Q38118863-2D097C62-3228-44F4-BEDD-8E2224DF1096

P2860

Renal fibrosis is attenuated by targeted disruption of KCa3.1 potassium channels.

http://www.wikidata.org/entity/Q37305118

description

article científic

@ca

article scientifique

@fr

articolo scientifico

@it

artigo científico

@pt

bilimsel makale

@tr

scientific article published on 13 August 2009

@en

vedecký článok

@sk

vetenskaplig artikel

@sv

videnskabelig artikel

@da

vědecký článek

@cs

name

Renal fibrosis is attenuated by targeted disruption of KCa3.1 potassium channels.

@en

Renal fibrosis is attenuated by targeted disruption of KCa3.1 potassium channels.

@nl

type

label

Renal fibrosis is attenuated by targeted disruption of KCa3.1 potassium channels.

@en

Renal fibrosis is attenuated by targeted disruption of KCa3.1 potassium channels.

@nl

prefLabel

Renal fibrosis is attenuated by targeted disruption of KCa3.1 potassium channels.

@en

Renal fibrosis is attenuated by targeted disruption of KCa3.1 potassium channels.

@nl

P1433

Q37305118-732DF548-90E6-4B19-A7FD-B5536631E977

P1476

Q37305118-2C513E6F-4860-4978-82C8-587C0DAEB188

P2093

Q37305118-1F9EDCE2-6516-4100-8F3C-B2B1A64775C6

Q37305118-1F9FB5A7-18A2-43EF-854D-2AAFBE65D01A

Q37305118-2E940F6F-4CB0-4BDD-8B55-43998387A2E0

Q37305118-55F505C8-976D-4954-882F-A22BB78D9303

Q37305118-58DCFD31-2423-4BA6-861F-1599E618225F

Q37305118-678FD6B7-59B1-43F1-9297-839FEEC3C215

Q37305118-79D36A60-FC32-462D-AF5B-B86686783866

Q37305118-A2823444-B457-4E04-8C04-6EDAA03BD8B0

Q37305118-AA710A39-B658-417D-AA1B-D4B78D4C5ACF

Q37305118-C32AF326-A1BE-4D8E-8073-A424B0A7468E

P2860

Q37305118-04DD04A5-2EA6-48BC-B6EA-F300D5605F5C

Q37305118-06C8FB1D-3D54-48E3-B0C4-22AAEC5D1E7A

Q37305118-0B45046A-0079-433C-80EC-5C1845CDF2C5

Q37305118-0CEA158A-ED17-4174-8F6E-2FDEA9507FBD

Q37305118-1161F039-79E2-4059-93D2-73B3EE4B5BCA

Q37305118-231375D8-8D69-4475-8474-829B6B85EB78

Q37305118-28AA953B-9B6B-4F8F-A31E-12A1A6D8131E

Q37305118-2C05F092-D11D-4C8D-9BAC-FCB5130248B7

Q37305118-327008C8-6ABD-4120-A1DE-EEF59FE4C51C

Q37305118-328131DA-4DF7-4D6D-8F5A-093682A21C5B

P304

Q37305118-3824DA95-F69A-4C9A-83F8-ADCC661A772B

P31

Q37305118-07379715-AA32-403B-AF2C-C432D9A0A290

P356

Q37305118-D3EC92C5-5187-47B3-AA10-9F283F946529

P407

Q37305118-5C69AF53-9E9C-4BBB-A0BC-5DA8E942A8D3

P433

Q37305118-BFA2B5CA-1951-42C1-8FCD-ADC03B559E7A

P478

Q37305118-BBD03883-C74E-4CCA-BD98-2BA6A0D704F9

P577

Q37305118-15B14872-0010-456B-82A1-053F9D104F04

P5875

Q37305118-7477F5FB-1174-40D7-A4F1-C17A58F61CF2

P698

Q37305118-5D2617A4-5FA3-4417-BDE9-1084225D17F3

P932

Q37305118-F43FF338-48A2-450F-B582-848C631C5EC6

P356

PNAS.0903458106

P1433

Proceedings of the National Academy of Sciences of the United States of America

P1476

Renal fibrosis is attenuated by targeted disruption of KCa3.1 potassium channels.

@en

P2093

Anja Müller

http://www.w3.org/2001/XMLSchema#string

Anuradha Kaistha

http://www.w3.org/2001/XMLSchema#string

Brajesh P Kaistha

http://www.w3.org/2001/XMLSchema#string

Christoph Busch

http://www.w3.org/2001/XMLSchema#string

Claudia Schmidt

http://www.w3.org/2001/XMLSchema#string

Eva Kiss

http://www.w3.org/2001/XMLSchema#string

Frank Strutz

http://www.w3.org/2001/XMLSchema#string

Girija Raman

http://www.w3.org/2001/XMLSchema#string

Heike Wulff

http://www.w3.org/2001/XMLSchema#string

Hermann-Josef Gröne

http://www.w3.org/2001/XMLSchema#string

P2860

A novel gene, hKCa4, encodes the calcium-activated potassium channel in human T lymphocytes

The intermediate-conductance calcium-activated potassium channel KCa3.1 contributes to atherogenesis in mice and humans

Design of a potent and selective inhibitor of the intermediate-conductance Ca2+-activated K+ channel, IKCa1: a potential immunosuppressant

Up-regulation of the IKCa1 potassium channel during T-cell activation. Molecular mechanism and functional consequences

Blockade of the intermediate-conductance calcium-activated potassium channel as a new therapeutic strategy for restenosis

Evidence that fibroblasts derive from epithelium during tissue fibrosis

Local delivery of the KCa3.1 blocker, TRAM-34, prevents acute angioplasty-induced coronary smooth muscle phenotypic modulation and limits stenosis.

TGF-beta 1 induces proliferation in human renal fibroblasts via induction of basic fibroblast growth factor (FGF-2).

Renal fibrosis: an update.

Ion channels and their functional role in vascular endothelium.

P304

14518-14523

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1073/PNAS.0903458106

http://www.w3.org/2001/XMLSchema#string

P407

P433

34

http://www.w3.org/2001/XMLSchema#string

P478

106

http://www.w3.org/2001/XMLSchema#string

P577

2009-08-13T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

26766612

http://www.w3.org/2001/XMLSchema#string

P698

19706538

http://www.w3.org/2001/XMLSchema#string

P932

2726862

http://www.w3.org/2001/XMLSchema#string