Identification of three physically and functionally distinct binding sites for C3b in human complement factor H by deletion mutagenesis.
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Structural analysis of the C-terminal region (modules 18-20) of complement regulator factor H (FH)Human factor H-related protein 5 (FHR-5). A new complement-associated proteinBivalent and co-operative binding of complement factor H to heparan sulfate and heparinHuman factor H deficiency. Mutations in framework cysteine residues and block in H protein secretion and intracellular catabolismStructure of complement factor H carboxyl-terminus reveals molecular basis of atypical haemolytic uremic syndrome.Structural basis for engagement by complement factor H of C3b on a self surfaceThe central portion of factor H (modules 10-15) is compact and contains a structurally deviant CCP moduleStructure of the N-terminal region of complement factor H and conformational implications of disease-linked sequence variationsSolution Structure of CCP Modules 10–12 Illuminates Functional Architecture of the Complement Regulator, Factor HDesign and Evaluation of Meningococcal Vaccines through Structure-Based Modification of Host and Pathogen MoleculesFunctional properties of complement factor H-related proteins FHR-3 and FHR-4: binding to the C3d region of C3b and differential regulation by heparinIdentification, characterization, and physiological actions of factor H as an adrenomedullin binding protein present in human plasmaProduction of biologically active complement factor H in therapeutically useful quantitiesDisease-associated sequence variations congregate in a polyanion recognition patch on human factor H revealed in three-dimensional structureIsolation and characterization of a novel rat factor H-related protein that is up-regulated in glomeruli under complement attackThe binding of factor H to a complex of physiological polyanions and C3b on cells is impaired in atypical hemolytic uremic syndrome.Identification of complement regulatory domains in vaccinia virus complement control protein.Complement factor H gene mutation associated with autosomal recessive atypical hemolytic uremic syndrome.Clustering of missense mutations in the C-terminal region of factor H in atypical hemolytic uremic syndrome.Structural and functional characterization of factor H mutations associated with atypical hemolytic uremic syndromeMutations in factor H reduce binding affinity to C3b and heparin and surface attachment to endothelial cells in hemolytic uremic syndrome.Spontaneous hemolytic uremic syndrome triggered by complement factor H lacking surface recognition domains.Translational mini-review series on complement factor H: renal diseases associated with complement factor H: novel insights from humans and animals.Complement factor H: using atomic resolution structure to illuminate disease mechanisms.Disease-associated N-terminal complement factor H mutations perturb cofactor and decay-accelerating activities.Crystallographic determination of the disease-associated T1184R variant of complement regulator factor H.Complementary recognition of alternative pathway activators by decay-accelerating factor and factor HRare complement factor H variant associated with age-related macular degeneration in the Amish.Complement evasion by Borrelia burgdorferi: serum-resistant strains promote C3b inactivation.Complement control protein factor H: the good, the bad, and the inadequate.The human complement regulator factor H binds pneumococcal surface protein PspC via short consensus repeats 13 to 15.Complement System Part I - Molecular Mechanisms of Activation and Regulation.Attempts to prepare suitable complement regulatory molecules for clinical xenotransplantation.Fusion protein comprising factor H domains 6 and 7 and human IgG1 Fc as an antibacterial immunotherapeuticStructure of vaccinia complement protein in complex with heparin and potential implications for complement regulation.Zinc binding to the Tyr402 and His402 allotypes of complement factor H: possible implications for age-related macular degeneration.Localization by site-directed mutagenesis of the site in human complement factor H that binds to Streptococcus pyogenes M protein.Mapping the Complement Factor H-Related Protein 1 (CFHR1):C3b/C3d Interactions.Plasma levels of complement proteins from the alternative pathway in patients with age-related macular degeneration are independent of Complement Factor H Tyr⁴⁰²His polymorphism.A novel sialic acid binding site on factor H mediates serum resistance of sialylated Neisseria gonorrhoeae.
P2860
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P2860
Identification of three physically and functionally distinct binding sites for C3b in human complement factor H by deletion mutagenesis.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on October 1996
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Identification of three physic ...... tor H by deletion mutagenesis.
@en
Identification of three physic ...... tor H by deletion mutagenesis.
@nl
type
label
Identification of three physic ...... tor H by deletion mutagenesis.
@en
Identification of three physic ...... tor H by deletion mutagenesis.
@nl
prefLabel
Identification of three physic ...... tor H by deletion mutagenesis.
@en
Identification of three physic ...... tor H by deletion mutagenesis.
@nl
P2860
P356
P1476
Identification of three physic ...... tor H by deletion mutagenesis.
@en
P2093
A K Sharma
M K Pangburn
P2860
P304
10996-11001
P356
10.1073/PNAS.93.20.10996
P407
P577
1996-10-01T00:00:00Z