Mutations in factor H reduce binding affinity to C3b and heparin and surface attachment to endothelial cells in hemolytic uremic syndrome.
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Deletion of complement factor H-related genes CFHR1 and CFHR3 is associated with atypical hemolytic uremic syndromeStructure of complement factor H carboxyl-terminus reveals molecular basis of atypical haemolytic uremic syndrome.Dual interaction of factor H with C3d and glycosaminoglycans in host-nonhost discrimination by complementAnnexin-II, DNA, and histones serve as factor H ligands on the surface of apoptotic cellsVariations in the complement regulatory genes factor H (CFH) and factor H related 5 (CFHR5) are associated with membranoproliferative glomerulonephritis type II (dense deposit disease)Genetics of HUS: the impact of MCP, CFH, and IF mutations on clinical presentation, response to treatment, and outcomeAlternative Pathway Dysregulation and the Conundrum of Complement Activation by IgG4 Immune Complexes in Membranous NephropathyThe complotype: dictating risk for inflammation and infectionGenetic variants in the complement system predisposing to age-related macular degeneration: a reviewMutations in complement factor I as found in atypical hemolytic uremic syndrome lead to either altered secretion or altered function of factor IComplement System Part II: Role in ImmunityProduction of biologically active recombinant human factor H in PhyscomitrellaThe development of atypical hemolytic uremic syndrome depends on complement C5Haemolytic uraemic syndrome.Analysis of rare variants in the C3 gene in patients with age-related macular degeneration.Haemolytic uraemic syndrome and mutations of the factor H gene: a registry-based study of German speaking countriesMutations in human complement regulator, membrane cofactor protein (CD46), predispose to development of familial hemolytic uremic syndrome.An interactive web database of factor H-associated hemolytic uremic syndrome mutations: insights into the structural consequences of disease-associated mutations.Primary glomerulonephritis with isolated C3 deposits: a new entity which shares common genetic risk factors with haemolytic uraemic syndrome.Modeling how CD46 deficiency predisposes to atypical hemolytic uremic syndromeGain-of-function mutations in complement factor B are associated with atypical hemolytic uremic syndrome.ADAMTS13 phenotype in plasma from normal individuals and patients with thrombotic thrombocytopenic purpuraSpontaneous hemolytic uremic syndrome triggered by complement factor H lacking surface recognition domains.Complement in glomerular injury.Translational mini-review series on complement factor H: genetics and disease associations of human complement factor H.Translational mini-review series on complement factor H: renal diseases associated with complement factor H: novel insights from humans and animals.The complement factor H R1210C mutation is associated with atypical hemolytic uremic syndromePlasma therapy in atypical haemolytic uremic syndrome: lessons from a family with a factor H mutation.Complement and the atypical hemolytic uremic syndrome in children.Advances in understanding of pathogenesis of aHUS and HELLP.Lack of association between polymorphisms in C4b-binding protein and atypical haemolytic uraemic syndrome in the Spanish population.Mutations of factor H impair regulation of surface-bound C3b by three mechanisms in atypical hemolytic uremic syndrome.Successful renal transplantation in a patient with atypical hemolytic uremic syndrome carrying mutations in both factor I and MCP.Atypical hemolytic uremic syndrome associated with complement factor H autoantibodies and CFHR1/CFHR3 deficiency.Thrombomodulin mutations in atypical hemolytic-uremic syndrome.DEAP-HUS: deficiency of CFHR plasma proteins and autoantibody-positive form of hemolytic uremic syndrome.Genetics and complement in atypical HUS.aHUS caused by complement dysregulation: new therapies on the horizon.Advances in understanding the aetiology of atypical Haemolytic Uraemic Syndrome.Disease-associated N-terminal complement factor H mutations perturb cofactor and decay-accelerating activities.
P2860
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P2860
Mutations in factor H reduce binding affinity to C3b and heparin and surface attachment to endothelial cells in hemolytic uremic syndrome.
description
2003 nî lūn-bûn
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2003 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
name
Mutations in factor H reduce b ...... in hemolytic uremic syndrome.
@ast
Mutations in factor H reduce b ...... in hemolytic uremic syndrome.
@en
type
label
Mutations in factor H reduce b ...... in hemolytic uremic syndrome.
@ast
Mutations in factor H reduce b ...... in hemolytic uremic syndrome.
@en
prefLabel
Mutations in factor H reduce b ...... in hemolytic uremic syndrome.
@ast
Mutations in factor H reduce b ...... in hemolytic uremic syndrome.
@en
P2093
P2860
P50
P356
P1476
Mutations in factor H reduce b ...... in hemolytic uremic syndrome.
@en
P2093
Hartmut P H Neumann
Jens Hellwage
Jessica Caprioli
Marina Noris
Mihaly Jozsi
Seppo Meri
Tamara Manuelian
P2860
P304
P356
10.1172/JCI16651
P407
P577
2003-04-01T00:00:00Z