NEMO/IKKgamma regulates an early NF-kappaB-independent cell-death checkpoint during TNF signaling. - Wikidata - wikimedia - TriplyDB

NEMO/IKKgamma regulates an early NF-kappaB-independent cell-death checkpoint during TNF signaling.

NEMO/IKKgamma regulates an early NF-kappaB-independent cell-death checkpoint during TNF signaling.

http://www.wikidata.org/entity/Q37308558

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Necroptosis in tumorigenesis, activation of anti-tumor immunity, and cancer therapy Molecular crosstalk between apoptosis, necroptosis, and survival signaling Poly-ubiquitination in TNFR1-mediated necroptosis RIPK3 contributes to TNFR1-mediated RIPK1 kinase-dependent apoptosis in conditions of cIAP1/2 depletion or TAK1 kinase inhibition Caspase 8 inhibits programmed necrosis by processing CYLD NEMO Prevents Steatohepatitis and Hepatocellular Carcinoma by Inhibiting RIPK1 Kinase Activity-Mediated Hepatocyte Apoptosis The lectin concanavalin-A signals MT1-MMP catalytic independent induction of COX-2 through an IKKgamma/NF-kappaB-dependent pathway.MK2 Phosphorylates RIPK1 to Prevent TNF-Induced Cell Death.The molecular regulation of programmed necrotic cell injury.Ursolic acid from Trailliaedoxa gracilis induces apoptosis in medullary thyroid carcinoma cells.NEMO inhibits programmed necrosis in an NFκB-independent manner by restraining RIP1.NF-κB Essential Modulator (NEMO) Is Critical for Thyroid Function.NEMO Prevents RIP Kinase 1-Mediated Epithelial Cell Death and Chronic Intestinal Inflammation by NF-κB-Dependent and -Independent Functions.NIK promotes tissue destruction independently of the alternative NF-κB pathway through TNFR1/RIP1-induced apoptosis.CYLD Proteolysis Protects Macrophages from TNF-Mediated Auto-necroptosis Induced by LPS and Licensed by Type I IFN.Chronicles of a death foretold: dual sequential cell death checkpoints in TNF signaling Going up in flames: necrotic cell injury and inflammatory diseases.Regulation of NF-κB signaling by caspases and MALT1 paracaspase.NFκB and ubiquitination: partners in disarming RIPK1-mediated cell death.Regulation of RIP1 kinase signalling at the crossroads of inflammation and cell death.Cloaked in ubiquitin, a killer hides in plain sight: the molecular regulation of RIPK1.Intracellular nicotinamide adenine dinucleotide promotes TNF-induced necroptosis in a sirtuin-dependent manner.More to Life than NF-κB in TNFR1 Signaling Cell death-independent activities of the death receptors CD95, TRAILR1, and TRAILR2.Roles of Caspases in Necrotic Cell Death.The histone deacetylase inhibitor vorinostat prevents TNFα-induced necroptosis by regulating multiple signaling pathways.The interplay of IKK, NF-κB and RIPK1 signaling in the regulation of cell death, tissue homeostasis and inflammation.Intermediate domain of receptor-interacting protein kinase 1 (RIPK1) determines switch between necroptosis and RIPK1 kinase-dependent apoptosis.The death domain kinase RIP1 links the immunoregulatory CD40 receptor to apoptotic signaling in carcinomas.A novel pVHL-independent but NEMO-driven pathway in renal cancer promotes HIF stabilization.Finding a new role for NEMO: A key player in preventing hepatocyte apoptosis and liver tumorigenesis by inhibiting RIPK1.TNFR1 determines progression of chronic liver injury in the IKKγ/Nemo genetic model.NEMO regulates a cell death switch in TNF signaling by inhibiting recruitment of RIPK3 to the cell death-inducing complex II.RIP1 comes back to life as a cell death regulator in TNFR1 signaling.NEMO nuances NF-kappaB.Electroacupuncture Suppresses the NF-κB Signaling Pathway by Upregulating Cylindromatosis to Alleviate Inflammatory Injury in Cerebral Ischemia/Reperfusion Rats.MK2 phosphorylation of RIPK1 regulates TNF-mediated cell death.Necroptosis and neutrophil-associated disorders.Mind Bomb Regulates Cell Death during TNF Signaling by Suppressing RIPK1's Cytotoxic Potential.Necroptosis in development and diseases.

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NEMO/IKKgamma regulates an early NF-kappaB-independent cell-death checkpoint during TNF signaling.

http://www.wikidata.org/entity/Q37308558

description

article científic

@ca

article scientifique

@fr

articolo scientifico

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artigo científico

@pt

bilimsel makale

@tr

scientific article published on 17 April 2009

@en

vedecký článok

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vetenskaplig artikel

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videnskabelig artikel

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vědecký článek

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name

NEMO/IKKgamma regulates an ear ...... eckpoint during TNF signaling.

@en

NEMO/IKKgamma regulates an ear ...... eckpoint during TNF signaling.

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type

label

NEMO/IKKgamma regulates an ear ...... eckpoint during TNF signaling.

@en

NEMO/IKKgamma regulates an ear ...... eckpoint during TNF signaling.

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prefLabel

NEMO/IKKgamma regulates an ear ...... eckpoint during TNF signaling.

@en

NEMO/IKKgamma regulates an ear ...... eckpoint during TNF signaling.

@nl

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Cell Death & Differentiation

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NEMO/IKKgamma regulates an ear ...... eckpoint during TNF signaling.

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A T Ting

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D Legarda-Addison

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H Hase

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M A O'Donnell

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P2860

Identification of a cell protein (FIP-3) as a modulator of NF-kappaB activity and as a target of an adenovirus inhibitor of tumor necrosis factor alpha-induced apoptosis

A20 inhibits tumor necrosis factor (TNF) alpha-induced apoptosis by disrupting recruitment of TRADD and RIP to the TNF receptor 1 complex in Jurkat T cells.

RIP: a novel protein containing a death domain that interacts with Fas/APO-1 (CD95) in yeast and causes cell death

Induction of TNF receptor I-mediated apoptosis via two sequential signaling complexes

TNF-alpha induces two distinct caspase-8 activation pathways

IKK-gamma is an essential regulatory subunit of the IkappaB kinase complex

Recruitment of the IKK signalosome to the p55 TNF receptor: RIP and A20 bind to NEMO (IKKgamma) upon receptor stimulation

FADD: essential for embryo development and signaling from some, but not all, inducers of apoptosis

cIAP1 and cIAP2 facilitate cancer cell survival by functioning as E3 ligases that promote RIP1 ubiquitination

Ubiquitination of RIP1 regulates an NF-kappaB-independent cell-death switch in TNF signaling

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1279-1288

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scholarly article

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10.1038/CDD.2009.41

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9

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16

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19373245

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