Common variants in the NLRP3 region contribute to Crohn's disease susceptibility. - Wikidata - wikimedia - TriplyDB

Common variants in the NLRP3 region contribute to Crohn's disease susceptibility.

Common variants in the NLRP3 region contribute to Crohn's disease susceptibility.

http://www.wikidata.org/entity/Q37310504

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Functional genetic screen of human diversity reveals that a methionine salvage enzyme regulates inflammatory cell death Involvement of matrix metalloproteinases (MMPs) and inflammasome pathway in molecular mechanisms of fibrosis Resolution of Inflammation: What Controls Its Onset?Diversity of Intestinal Macrophages in Inflammatory Bowel Diseases Mitochondrial dysfunction in inflammatory bowel disease Pattern Recognition Receptors in Cancer Progression and Metastasis NOD-Like Receptors: Master Regulators of Inflammation and Cancer Pattern-recognition receptors and gastric cancer Role of genetics in the diagnosis and prognosis of Crohn's disease Association among genetic predisposition, gut microbiota, and host immune response in the etiopathogenesis of inflammatory bowel disease NLRP3 inflammasome and its inhibitors: a review Intestinal barrier in inflammatory bowel disease Inflammasome in intestinal inflammation and cancer The role of innate immunity receptors in the pathogenesis of inflammatory bowel disease Structural and Functional Analysis of the NLRP4 Pyrin Domain The inflammasome: an emerging therapeutic oncotarget for cancer prevention Bacterial recognition pathways that lead to inflammasome activation Inflammasomes: caspase-1-activating platforms with critical roles in host defense Polymorphisms in inflammasome genes and risk of coal workers' pneumoconiosis in a Chinese population Effects of the Interactions between Dust Exposure and Genetic Polymorphisms in Nalp3, Caspase-1, and IL-1β on the Risk of Silicosis: A Case-Control Study The inflammasome adaptor ASC regulates the function of adaptive immune cells by controlling Dock2-mediated Rac activation and actin polymerization Inflammatory bowel disease Involvement of the same TNFR1 residue in mendelian and multifactorial inflammatory disorders.NLRP3 inflammasome plays a key role in the regulation of intestinal homeostasis.Genetic variation in the familial Mediterranean fever gene (MEFV) and risk for Crohn's disease and ulcerative colitis.The inflammasomes.IL-1beta processing in host defense: beyond the inflammasomes.Omics Approaches to Identify Potential Biomarkers of Inflammatory Diseases in the Focal Adhesion Complex.Huaier aqueous extract protects against dextran sulfate sodium-induced experimental colitis in mice by inhibiting NLRP3 inflammasome activation.The DNA Sensor AIM2 Maintains Intestinal Homeostasis via Regulation of Epithelial Antimicrobial Host Defense.Escherichia coli isolates from inflammatory bowel diseases patients survive in macrophages and activate NLRP3 inflammasome.Nlrp3: an immune sensor of cellular stress and infection The NLRP3 inflammasome functions as a negative regulator of tumorigenesis during colitis-associated cancer.Polymorphism of NLRP3 Gene and Association with Susceptibility to Digestive Disorders in Rabbit NOD-like receptors in intestinal homeostasis and epithelial tissue repair.Crohn's disease: NOD2, autophagy and ER stress converge.Genetic and functional profiling of Crohn's disease: autophagy mechanism and susceptibility to infectious diseases Innate immunity in the small intestine.The role of bacteria and pattern-recognition receptors in Crohn's disease.NLRC5 knockdown in chicken macrophages alters response to LPS and poly (I:C) stimulation.

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Common variants in the NLRP3 region contribute to Crohn's disease susceptibility.

http://www.wikidata.org/entity/Q37310504

description

article científic

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article scientifique

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articolo scientifico

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artigo científico

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bilimsel makale

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scientific article published on 21 December 2008

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vedecký článok

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vetenskaplig artikel

@sv

videnskabelig artikel

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vědecký článek

@cs

name

Common variants in the NLRP3 region contribute to Crohn's disease susceptibility.

@en

Common variants in the NLRP3 region contribute to Crohn's disease susceptibility.

@nl

type

label

Common variants in the NLRP3 region contribute to Crohn's disease susceptibility.

@en

Common variants in the NLRP3 region contribute to Crohn's disease susceptibility.

@nl

prefLabel

Common variants in the NLRP3 region contribute to Crohn's disease susceptibility.

@en

Common variants in the NLRP3 region contribute to Crohn's disease susceptibility.

@nl

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Nature Genetics

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Common variants in the NLRP3 region contribute to Crohn's disease susceptibility.

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Alain Bitton

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Albert Cohen

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Alexandra-Chloé Villani

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Catherine Collette

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Cécile Libioulle

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Daniel Gaudet

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Denis Franchimont

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Diane Langelier

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Edouard Louis

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Geneviève Fortin

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P2860

Inflammatory Bowel Disease

Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease

Stimulation of the intracellular bacterial sensor NOD2 programs dendritic cells to promote interleukin-17 production in human memory T cells

NALP3 forms an IL-1beta-processing inflammasome with increased activity in Muckle-Wells autoinflammatory disorder

Inflammasome components NALP 1 and 3 show distinct but separate expression profiles in human tissues suggesting a site-specific role in the inflammatory response

Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls

Genome-wide association study identifies new susceptibility loci for Crohn disease and implicates autophagy in disease pathogenesis

Transmission test for linkage disequilibrium: the insulin gene region and insulin-dependent diabetes mellitus (IDDM)

Haploview: analysis and visualization of LD and haplotype maps

Inflammatory caspases and inflammasomes: master switches of inflammation

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71-76

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scholarly article

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10.1038/NG.285

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1

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41

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2008-12-21T00:00:00Z

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23680448

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19098911

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Crohn's disease

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2728932

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