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IL-10 Production Is Critical for Sustaining the Expansion of CD5+ B and NKT Cells and Restraining Autoantibody Production in Congenic Lupus-Prone MiceCancer Cells Hijack PRC2 to Modify Multiple Cytokine PathwaysOccupational and environmental exposures and risk of systemic lupus erythematosus: silica, sunlight, solvents.Evaluation of clinical outcomes and renal vascular pathology among patients with lupus.B cell activating factor (BAFF) and T cells cooperate to breach B cell tolerance in lupus-prone New Zealand Black (NZB) miceMultiple tolerance defects contribute to the breach of B cell tolerance in New Zealand Black chromosome 1 congenic miceA targeted association study in systemic lupus erythematosus identifies multiple susceptibility alleles.TLR tolerance reduces IFN-alpha production despite plasmacytoid dendritic cell expansion and anti-nuclear antibodies in NZB bicongenic mice.T cell and dendritic cell abnormalities synergize to expand pro-inflammatory T cell subsets leading to fatal autoimmunity in B6.NZBc1 lupus-prone miceAnti-nucleosome antibodies outperform traditional biomarkers as longitudinal indicators of disease activity in systemic lupus erythematosusGenetic association analyses implicate aberrant regulation of innate and adaptive immunity genes in the pathogenesis of systemic lupus erythematosus.Reduced proportions of natural killer T cells are present in the relatives of lupus patients and are associated with autoimmunity.Identification of a lupus-susceptibility locus leading to impaired clearance of apoptotic debris on New Zealand Black chromosome 13.Common variants in the NLRP3 region contribute to Crohn's disease susceptibility.A discrete cluster of urinary biomarkers discriminates between active systemic lupus erythematosus patients with and without glomerulonephritis.Presence of an interferon signature in individuals who are anti-nuclear antibody positive lacking a systemic autoimmune rheumatic disease diagnosis.Bone marrow-derived human hematopoietic stem cells engraft NOD/SCID mice and traffic appropriately to an inflammatory stimulus in the joint.Molecular markers of injury in kidney biopsy specimens of patients with lupus nephritisTransancestral mapping and genetic load in systemic lupus erythematosus.Lack of Interferon and Proinflammatory Cyto/chemokines in Serologically Active Clinically Quiescent Systemic Lupus Erythematosus.Identification of the SLAM Adapter Molecule EAT-2 as a Lupus-Susceptibility Gene That Acts through Impaired Negative Regulation of Dendritic Cell Signaling.Suppression of autoimmunity by CD5(+) IL-10-producing B cells in lupus-prone mice.The B-cell transmembrane protein CD72 binds to and is an in vivo substrate of the protein tyrosine phosphatase SHP-1.Association of LY9 in UK and Canadian SLE families.Molecular basis of antigen recognition by insulin specific T cell receptor.Anti-dsDNA and Antichromatin Antibody Isotypes in Serologically Active Clinically Quiescent Systemic Lupus Erythematosus.Altered expression of TNF-alpha signaling pathway proteins in systemic lupus erythematosus.Experimental evidence that mutated-self peptides derived from mitochondrial DNA somatic mutations have the potential to trigger autoimmunity.Invariant NKT Cell Activation Is Potentiated by Homotypic trans-Ly108 Interactions.Healthcare cost and loss of productivity in a Canadian population of patients with and without lupus nephritis.Colocalization of expansion of the splenic marginal zone population with abnormal B cell activation and autoantibody production in B6 mice with an introgressed New Zealand Black chromosome 13 interval.Functional dissection of lupus susceptibility loci on the New Zealand black mouse chromosome 1: evidence for independent genetic loci affecting T and B cell activation.Genetic engineering in primary human B cells with CRISPR-Cas9 ribonucleoproteins.Epistatic suppression of fatal autoimmunity in New Zealand black bicongenic mice.Identification of a neutrophil-related gene expression signature that is enriched in adult systemic lupus erythematosus patients with active nephritis: Clinical/pathologic associations and etiologic mechanisms.A tyrosine sulfation-dependent HLA-I modification identifies memory B cells and plasma cellsThe presence of anti-nuclear antibodies alone is associated with changes in B cell activation and T follicular helper cells similar to those in systemic autoimmune rheumatic diseaseDevelopment, Sensibility, and Validity of a Systemic Autoimmune Rheumatic Disease Case Ascertainment ToolTolerance is overcome in beef insulin-transgenic mice by activation of low-affinity autoreactive T cellsBoth MHC and background gene heterozygosity alter T cell receptor repertoire selection in an antigen-specific response
P50
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P50
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researcher
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wetenschapper
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հետազոտող
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Joan Wither
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Joan Wither
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Joan Wither
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Joan Wither
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Joan Wither
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Joan Wither
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Joan Wither
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Joan Wither
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Joan Wither
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Joan Wither
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Joan Wither
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Joan Wither
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P1153
7004822171
P31
P496
0000-0001-5961-9228