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The cAMP binding protein Epac regulates cardiac myofilament function.

The cAMP binding protein Epac regulates cardiac myofilament function.

http://www.wikidata.org/entity/Q37310787

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Targeting protein-protein interactions in complexes organized by A kinase anchoring proteins Suppression of Rap1 impairs cardiac myofibrils and conduction system in zebrafish Targeting the sarcomere to correct muscle function Protein kinase D increases maximal Ca2+-activated tension of cardiomyocyte contraction by phosphorylation of cMyBP-C-Ser315 Epac enhances excitation-transcription coupling in cardiac myocytes Thin filament incorporation of an engineered cardiac troponin C variant (L48Q) enhances contractility in intact cardiomyocytes from healthy and infarcted hearts.Epac2 mediates cardiac β1-adrenergic-dependent sarcoplasmic reticulum Ca2+ leak and arrhythmia.Regulation of cAMP homeostasis by the efflux protein MRP4 in cardiac myocytes.Role of phospholipase Cε in physiological phosphoinositide signaling networks.β-Adrenergic receptors stimulate interleukin-6 production through Epac-dependent activation of PKCδ/p38 MAPK signalling in neonatal mouse cardiac fibroblasts ACE inhibition prevents diastolic Ca2+ overload and loss of myofilament Ca2+ sensitivity after myocardial infarction.Inhibition of Epac1 suppresses mitochondrial fission and reduces neointima formation induced by vascular injury.Long-term consumption of an obesogenic high fat diet prior to ischemia-reperfusion mediates cardioprotection via Epac1-dependent signaling.CaMKII effects on inotropic but not lusitropic force frequency responses require phospholamban.Beta-adrenergic receptor signaling in the heart: role of CaMKII.Functional and cardioprotective effects of simultaneous and individual activation of protein kinase A and Epac.G protein-dependent and G protein-independent signaling pathways and their impact on cardiac function.Phosphodiesterases and subcellular compartmentalized cAMP signaling in the cardiovascular system.Role of Epac in brain and heart.Molecular mechanisms of AGE/RAGE-mediated fibrosis in the diabetic heart.The role of Epac in the heart.Inflammation and cardiac dysfunction during sepsis, muscular dystrophy, and myocarditis.Upregulation of cardiomyocyte ribonucleotide reductase increases intracellular 2 deoxy-ATP, contractility, and relaxation.cAMP inhibits modulation of airway smooth muscle phenotype via the exchange protein activated by cAMP (Epac) and protein kinase A Rapid effects of aldosterone in primary cultures of cardiomyocytes - do they suggest the existence of a membrane-bound receptor?Epac as a novel effector of airway smooth muscle relaxation.Differential regulation of cardiac excitation-contraction coupling by cAMP phosphodiesterase subtypes.Epac2-dependent mobilization of intracellular Ca²+ by glucagon-like peptide-1 receptor agonist exendin-4 is disrupted in β-cells of phospholipase C-ε knockout mice.CaMKII-dependent myofilament Ca2+ desensitization contributes to the frequency-dependent acceleration of relaxation.New Antihyperglycemic Drugs and Heart Failure: Synopsis of Basic and Clinical Data.Structure-activity relationships of 2-substituted phenyl-N-phenyl-2-oxoacetohydrazonoyl cyanides as novel antagonists of exchange proteins directly activated by cAMP (EPACs).Early effects of Epac depend on the fine-tuning of the sarcoplasmic reticulum Ca2+ handling in cardiomyocytes.Depotentiation of intact rat cardiac muscle unmasks an Epac-dependent increase in myofilament Ca(2+) sensitivity.Epac Function and cAMP Scaffolds in the Heart and Lung.Epac activation inhibits IL-6-induced cardiac myocyte dysfunction.Interaction of Epac with Non-canonical Cyclic Nucleotides.Intracellular cAMP Sensor EPAC: Physiology, Pathophysiology, and Therapeutics Development.Exchange protein directly activated by cAMP 1 promotes autophagy during cardiomyocyte hypertrophy.Pre-exposure to adenosine, acting via A(2A) receptors on endothelial cells, alters the protein kinase A dependence of adenosine-induced dilation in skeletal muscle resistance arterioles.Mechanisms underlying the activation of L-type calcium channels by urocortin in rat ventricular myocytes.

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The cAMP binding protein Epac regulates cardiac myofilament function.

http://www.wikidata.org/entity/Q37310787

description

article científic

@ca

article scientifique

@fr

articolo scientifico

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artigo científico

@pt

bilimsel makale

@tr

scientific article published on 06 August 2009

@en

vedecký článok

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vetenskaplig artikel

@sv

videnskabelig artikel

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vědecký článek

@cs

name

The cAMP binding protein Epac regulates cardiac myofilament function.

@en

The cAMP binding protein Epac regulates cardiac myofilament function.

@nl

type

label

The cAMP binding protein Epac regulates cardiac myofilament function.

@en

The cAMP binding protein Epac regulates cardiac myofilament function.

@nl

prefLabel

The cAMP binding protein Epac regulates cardiac myofilament function.

@en

The cAMP binding protein Epac regulates cardiac myofilament function.

@nl

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PNAS.0812536106

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Proceedings of the National Academy of Sciences of the United States of America

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The cAMP binding protein Epac regulates cardiac myofilament function.

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Alain Lacampagne

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Alexandre Lucas

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Florence Poirier

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Olivier Cazorla

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P2860

Epac is a Rap1 guanine-nucleotide-exchange factor directly activated by cyclic AMP

A family of cAMP-binding proteins that directly activate Rap1

Cardiac myosin binding protein C: its role in physiology and disease

Phosphorylation switches specific for the cardiac isoform of myosin binding protein-C: a modulator of cardiac contraction?

Myosin binding protein C, a phosphorylation-dependent force regulator in muscle that controls the attachment of myosin heads by its interaction with myosin S2

A new phospholipase-C-calcium signalling pathway mediated by cyclic AMP and a Rap GTPase

Changes in cardiac contractility related to calcium-mediated changes in phosphorylation of myosin-binding protein C.

Cardiac excitation-contraction coupling

Length and protein kinase A modulations of myocytes in cardiac myosin binding protein C-deficient mice

Cardiac troponin I mutants. Phosphorylation by protein kinases C and A and regulation of Ca(2+)-stimulated MgATPase of reconstituted actomyosin S-1

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14144-14149

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scholarly article

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10.1073/PNAS.0812536106

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33

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106

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Frank Lezoualc'h

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2009-08-06T00:00:00Z

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26728359

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19666481

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2729034

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