Following activation of the amyloid cascade, apolipoprotein E4 drives the in vivo oligomerization of amyloid-β resulting in neurodegeneration.

Following activation of the amyloid cascade, apolipoprotein E4 drives the in vivo oligomerization of amyloid-β resulting in neurodegeneration.

Item
http://www.wikidata.org/entity/Q37313065
ApoE4 induces Aβ42, tau, and neuronal pathology in the hippocampus of young targeted replacement apoE4 mice.Amyloid-beta and Alzheimer's disease: the role of neprilysin-2 in amyloid-beta clearanceApoE4-Driven Accumulation of Intraneuronal Oligomerized Aβ42 following Activation of the Amyloid Cascade In Vivo Is Mediated by a Gain of Function.APOE4 enhances age-dependent decline in cognitive function by down-regulating an NMDA receptor pathway in EFAD-Tg mice.High-resolution 3D reconstruction reveals intra-synaptic amyloid fibrils.Characterization of Aldh2 (-/-) mice as an age-related model of cognitive impairment and Alzheimer's diseaseCholesterol level and statin use in Alzheimer disease: II. Review of human trials and recommendations.Amyloid-Related Memory Decline in Preclinical Alzheimer's Disease Is Dependent on APOE ε4 and Is Detectable over 18-Months.Increased Aβ42-α7-like nicotinic acetylcholine receptor complex level in lymphocytes is associated with apolipoprotein E4-driven Alzheimer's disease pathogenesis.Involvement of the Apoer2 and Lrp1 receptors in mediating the pathological effects of ApoE4 in vivo.Impaired Autophagy in APOE4 Astrocytes.Human Central Nervous System (CNS) ApoE Isoforms Are Increased by Age, Differentially Altered by Amyloidosis, and Relative Amounts Reversed in the CNS Compared with Plasma.Synthesis and application of β-carbolines as novel multi-functional anti-Alzheimer's disease agents.
P2860

Following activation of the amyloid cascade, apolipoprotein E4 drives the in vivo oligomerization of amyloid-β resulting in neurodegeneration.

Item
http://www.wikidata.org/entity/Q37313065
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on January 2010
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Following activation of the am ...... esulting in neurodegeneration.
@en
Following activation of the am ...... esulting in neurodegeneration.
@nl
type
label
Following activation of the am ...... esulting in neurodegeneration.
@en
Following activation of the am ...... esulting in neurodegeneration.
@nl
prefLabel
Following activation of the am ...... esulting in neurodegeneration.
@en
Following activation of the am ...... esulting in neurodegeneration.
@nl
P1433
P1476
P2093
P2860
P304
P31
P356
P433
P478
P50
P577
P698
P932
P356
P1433
P1476
Following activation of the am ...... esulting in neurodegeneration.
@en
P2093
P2860
P304
P31
P356
P433
P478
P50
P577
P698
P932