The weaver mutation of GIRK2 results in a loss of inwardly rectifying K+ current in cerebellar granule cells
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Properties of KvLQT1 K+ channel mutations in Romano-Ward and Jervell and Lange-Nielsen inherited cardiac arrhythmiasCerebellar ataxia and Purkinje cell dysfunction caused by Ca2+-activated K+ channel deficiencyHuman gamma-aminobutyric acid type B receptors are differentially expressed and regulate inwardly rectifying K+ channelsNormal cerebellar development but susceptibility to seizures in mice lacking G protein-coupled, inwardly rectifying K+ channel GIRK2The unipolar brush cell: a remarkable neuron finally receiving deserved attentionChannelopathies: ion channel defects linked to heritable clinical disorders.Discovery Genetics - The History and Future of Spontaneous Mutation Research.Keppen-Lubinsky syndrome is caused by mutations in the inwardly rectifying K+ channel encoded by KCNJ6.Electrophysiological, morphological, and topological properties of two histochemically distinct subpopulations of cerebellar unipolar brush cells.Defective gamma-aminobutyric acid type B receptor-activated inwardly rectifying K+ currents in cerebellar granule cells isolated from weaver and Girk2 null mutant mice.Medulloblastoma can be initiated by deletion of Patched in lineage-restricted progenitors or stem cellsA regenerative link in the ionic fluxes through the weaver potassium channel underlies the pathophysiology of the mutation.The weaver mouse: a most cantankerous rodent.Coenzyme Q10 inhibits mitochondrial complex-1 down-regulation and nuclear factor-kappa B activation.Diverse cell death pathways result from a single missense mutation in weaver mouse.Topology of ionotropic glutamate receptors in brains of heterozygous and homozygous weaver mutant mice.A cell cycle alteration precedes apoptosis of granule cell precursors in the weaver mouse cerebellum.Inhibition of caspases protects cerebellar granule cells of the weaver mouse from apoptosis and improves behavioral phenotype.Inhibition of insulin-like growth factor I activity contributes to the premature apoptosis of cerebellar granule neuron in weaver mutant mice: in vitro analysis.Properties and modulation of the G protein-coupled K+ channel in rat cerebellar granule neurons: ATP versus phosphatidylinositol 4,5-bisphosphate.Voltage-gated calcium channels mediate intracellular calcium increase in weaver dopaminergic neurons during stimulation of D2 and GABAB receptors.Ionic mechanism of electroresponsiveness in cerebellar granule cells implicates the action of a persistent sodium current.Cholesterol up-regulates neuronal G protein-gated inwardly rectifying potassium (GIRK) channel activity in the hippocampus.BAPTA-AM and ethanol protect cerebellar granule neurons from the destructive effect of the weaver gene.Selective Purkinje cell ectopia in the cerebellum of the weaver mouse.Coupling of rat somatostatin receptor subtypes to a G-protein gated inwardly rectifying potassium channel (GIRK1).Evidence of elevated intracellular calcium levels in weaver homozygote mice.Sperm GIRK2-containing K+ inward rectifying channels participate in sperm capacitation and fertilization.
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P2860
The weaver mutation of GIRK2 results in a loss of inwardly rectifying K+ current in cerebellar granule cells
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on October 1996
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
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vědecký článek
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name
The weaver mutation of GIRK2 r ...... nt in cerebellar granule cells
@en
The weaver mutation of GIRK2 r ...... t in cerebellar granule cells.
@nl
type
label
The weaver mutation of GIRK2 r ...... nt in cerebellar granule cells
@en
The weaver mutation of GIRK2 r ...... t in cerebellar granule cells.
@nl
prefLabel
The weaver mutation of GIRK2 r ...... nt in cerebellar granule cells
@en
The weaver mutation of GIRK2 r ...... t in cerebellar granule cells.
@nl
P2860
P50
P356
P1476
The weaver mutation of GIRK2 r ...... nt in cerebellar granule cells
@en
P2860
P304
11191-11195
P356
10.1073/PNAS.93.20.11191
P4011
0128b72dba5a16dd721d824cdc4d2990d698fc6c
P407
P577
1996-10-01T00:00:00Z