Akt1 signaling regulates integrin activation, matrix recognition, and fibronectin assembly
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EphA2 mediates ligand-dependent inhibition and ligand-independent promotion of cell migration and invasion via a reciprocal regulatory loop with AktCooperation between integrin alphavbeta3 and VEGFR2 in angiogenesisMultiple roles of toll-like receptor 4 in colorectal cancerStability and function of adult vasculature is sustained by Akt/Jagged1 signalling axis in endothelium.P21 activated kinase-1 (Pak1) promotes prostate tumor growth and microinvasion via inhibition of transforming growth factor β expression and enhanced matrix metalloproteinase 9 secretionRac1 activation driven by 14-3-3ζ dimerization promotes prostate cancer cell-matrix interactions, motility and transendothelial migrationNeuregulin-1 regulates cell adhesion via an ErbB2/phosphoinositide-3 kinase/Akt-dependent pathway: potential implications for schizophrenia and cancer.Integrins as "functional hubs" in the regulation of pathological angiogenesisSimultaneous modulation of the intrinsic and extrinsic pathways by simvastatin in mediating prostate cancer cell apoptosisUp-regulation of thrombospondin-2 in Akt1-null mice contributes to compromised tissue repair due to abnormalities in fibroblast function.TGFβ- and bleomycin-induced extracellular matrix synthesis is mediated through Akt and mammalian target of rapamycin (mTOR)Extranuclear signaling of mutated thyroid hormone receptors in promoting metastatic spread in thyroid carcinogenesisCigarette smoke induces Akt protein degradation by the ubiquitin-proteasome systemp70 S6-kinase mediates the cooperation between Akt1 and Mek1 pathways in fibroblast-mediated extracellular matrix remodelingpGlcNAc Nanofiber Treatment of Cutaneous Wounds Stimulate Increased Tensile Strength and Reduced Scarring via Activation of Akt1.Differential effects of Akt1 signaling on short- versus long-term consequences of myocardial infarction and reperfusion injurySelective signaling by Akt1 controls osteoblast differentiation and osteoblast-mediated osteoclast development.The Akt inhibitor, triciribine, ameliorates chronic hypoxia-induced vascular pruning and TGFβ-induced pulmonary fibrosis.The fibronectin III-1 domain activates a PI3-Kinase/Akt signaling pathway leading to αvβ5 integrin activation and TRAIL resistance in human lung cancer cells.Akt1 mediates prostate cancer cell microinvasion and chemotaxis to metastatic stimuli via integrin β₃ affinity modulation.Dasatinib inhibits TGFβ-induced myofibroblast differentiation through Src-SRF Pathway.Defining Akt actions in muscle differentiation.TGFβ1 induces apoptosis in invasive prostate cancer and bladder cancer cells via Akt-independent, p38 MAPK and JNK/SAPK-mediated activation of caspasesP38MAP kinase, but not phosphoinositol-3 kinase, signal downstream of glutamine-mediated fibronectin-integrin signaling after intestinal injury.14-3-3beta-Rac1-p21 activated kinase signaling regulates Akt1-mediated cytoskeletal organization, lamellipodia formation and fibronectin matrix assemblybeta1 integrin cytoplasmic domain residues selectively modulate fibronectin matrix assembly and cell spreading through talin and Akt-1.Akt1 is necessary for the vascular maturation and angiogenesis during cutaneous wound healing.Coordinate regulation of estrogen-mediated fibronectin matrix assembly and epidermal growth factor receptor transactivation by the G protein-coupled receptor, GPR30.Akt1 mediates α-smooth muscle actin expression and myofibroblast differentiation via myocardin and serum response factor.Integrin and growth factor receptor alliance in angiogenesis.Phosphoinositide 3-kinases in cell migration.Multimodal imaging reveals a role for Akt1 in fetal cardiac development.The Roles of PI3K/AKT/mTOR and MAPK/ERK Signaling Pathways in Human Pheochromocytomas.Interference with akt signaling protects against myocardial infarction and death by limiting the consequences of oxidative stress.Plasma and cellular fibronectin: distinct and independent functions during tissue repair.KCa1.1 channels regulate β1-integrin function and cell adhesion in rheumatoid arthritis fibroblast-like synoviocytes.Insulin-like growth factor 1 increases apical fibronectin in blastocysts to increase blastocyst attachment to endometrial epithelial cells in vitro.Modulation of long-term endothelial-barrier integrity is conditional to the cross-talk between Akt and Src signaling.Sulfatase-mediated manipulation of the astrocyte-Schwann cell interface.Survivin enhances motility of melanoma cells by supporting Akt activation and {alpha}5 integrin upregulation.
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Akt1 signaling regulates integrin activation, matrix recognition, and fibronectin assembly
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on 11 June 2007
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Akt1 signaling regulates integ ...... tion, and fibronectin assembly
@en
Akt1 signaling regulates integ ...... ion, and fibronectin assembly.
@nl
type
label
Akt1 signaling regulates integ ...... tion, and fibronectin assembly
@en
Akt1 signaling regulates integ ...... ion, and fibronectin assembly.
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prefLabel
Akt1 signaling regulates integ ...... tion, and fibronectin assembly
@en
Akt1 signaling regulates integ ...... ion, and fibronectin assembly.
@nl
P2093
P2860
P356
P1476
Akt1 signaling regulates integ ...... tion, and fibronectin assembly
@en
P2093
Eugene S Kandel
Nissim Hay
Payaningal R Somanath
Tatiana V Byzova
P2860
P304
22964-22976
P356
10.1074/JBC.M700241200
P407
P577
2007-06-11T00:00:00Z