The concerted action of Msh2 and UNG stimulates somatic hypermutation at A . T base pairs.
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DNA glycosylases: in DNA repair and beyondMSH2/MSH6 complex promotes error-free repair of AID-induced dU:G mispairs as well as error-prone hypermutation of A:T sitesDifferential expression of APE1 and APE2 in germinal centers promotes error-prone repair and A:T mutations during somatic hypermutationProximity to AGCT sequences dictates MMR-independent versus MMR-dependent mechanisms for AID-induced mutation via UNG2.Refining the Neuberger model: Uracil processing by activated B cells.Negative supercoiling creates single-stranded patches of DNA that are substrates for AID-mediated mutagenesis.Elevated incidence of polyp formation in APC(Min/⁺)Msh2⁻/⁻ mice is independent of nitric oxide-induced DNA mutationsOverlapping hotspots in CDRs are critical sites for V region diversificationMismatch-mediated error prone repair at the immunoglobulin genes.Does DNA repair occur during somatic hypermutation?AIDing antibody diversity by error-prone mismatch repair.Biochemical basis of immunological and retroviral responses to DNA-targeted cytosine deamination by activation-induced cytidine deaminase and APOBEC3G.DNA polymerases β and λ do not directly affect Ig variable region somatic hypermutation although their absence reduces the frequency of mutations.AID: a riddle wrapped in a mystery inside an enigma.The dual nature of mismatch repair as antimutator and mutator: for better or for worse.Pms2 and uracil-DNA glycosylases act jointly in the mismatch repair pathway to generate Ig gene mutations at A-T base pairs.Rev1 is essential in generating G to C transversions downstream of the Ung2 pathway but not the Msh2+Ung2 hybrid pathway.SAMHD1 enhances immunoglobulin hypermutation by promoting transversion mutation.
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The concerted action of Msh2 and UNG stimulates somatic hypermutation at A . T base pairs.
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article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 13 July 2009
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
The concerted action of Msh2 a ...... rmutation at A . T base pairs.
@en
The concerted action of Msh2 a ...... rmutation at A . T base pairs.
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The concerted action of Msh2 a ...... rmutation at A . T base pairs.
@en
The concerted action of Msh2 a ...... rmutation at A . T base pairs.
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The concerted action of Msh2 a ...... rmutation at A . T base pairs.
@en
The concerted action of Msh2 a ...... rmutation at A . T base pairs.
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P2093
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The concerted action of Msh2 a ...... rmutation at A . T base pairs.
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Alberto Martin
Cathy Collins
Darina Frieder
Mani Larijani
Marc Shulman
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10.1128/MCB.00647-09
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P577
2009-07-13T00:00:00Z