Somatic hypermutation in MutS homologue (MSH)3-, MSH6-, and MSH3/MSH6-deficient mice reveals a role for the MSH2-MSH6 heterodimer in modulating the base substitution pattern
about
Lack of MSH2 involvement differentiates V(D)J recombination from other non-homologous end joining eventsDNA glycosylases: in DNA repair and beyondRelated Mechanisms of Antibody Somatic Hypermutation and Class Switch RecombinationMSH2/MSH6 complex promotes error-free repair of AID-induced dU:G mispairs as well as error-prone hypermutation of A:T sitesAID mutates E. coli suggesting a DNA deamination mechanism for antibody diversificationDifferential expression of APE1 and APE2 in germinal centers promotes error-prone repair and A:T mutations during somatic hypermutationStructural, molecular and cellular functions of MSH2 and MSH6 during DNA mismatch repair, damage signaling and other noncanonical activitiesRole for mismatch repair proteins Msh2, Mlh1, and Pms2 in immunoglobulin class switching shown by sequence analysis of recombination junctionsAltered somatic hypermutation and reduced class-switch recombination in exonuclease 1-mutant miceMsh2 ATPase activity is essential for somatic hypermutation at a-T basepairs and for efficient class switch recombinationExamination of Msh6- and Msh3-deficient mice in class switching reveals overlapping and distinct roles of MutS homologues in antibody diversificationWhat we can learn about Escherichia coli through application of Gene OntologyActivation-induced deaminase, AID, is catalytically active as a monomer on single-stranded DNA.Proximity to AGCT sequences dictates MMR-independent versus MMR-dependent mechanisms for AID-induced mutation via UNG2.Incomplete Segregation of MSH6 Frameshift Variants with Phenotype of Lynch Syndrome.Altered spectra of hypermutation in DNA repair-deficient mice.Different mutation signatures in DNA polymerase eta- and MSH6-deficient mice suggest separate roles in antibody diversificationSwitch junction sequences in PMS2-deficient mice reveal a microhomology-mediated mechanism of Ig class switch recombination.Somatic immunoglobulin hypermutation.AID and somatic hypermutation.Evolution and the molecular basis of somatic hypermutation of antigen receptor genes.Controlling somatic hypermutation in immunoglobulin variable and switch regions.Msh6 protects mature B cells from lymphoma by preserving genomic stability.Linking class-switch recombination with somatic hypermutation.MSH2-MSH6 stimulates DNA polymerase eta, suggesting a role for A:T mutations in antibody genes.Mutagenesis dependent upon the combination of activation-induced deaminase expression and a double-strand breakDNA polymerase eta is the sole contributor of A/T modifications during immunoglobulin gene hypermutation in the mouse.DNA breaks in hypermutating immunoglobulin genes: evidence for a break-and-repair pathway of somatic hypermutationRegulation of hypermutation by activation-induced cytidine deaminase phosphorylationp21 is dispensable for AID-mediated class switch recombination and mutagenesis of immunoglobulin genes during somatic hypermutation.AID and mismatch repair in antibody diversification.Dimerization of MLH1 and PMS2 limits nuclear localization of MutLalpha.Hyper-IgM syndrome type 4 with a B lymphocyte-intrinsic selective deficiency in Ig class-switch recombination.What role for AID: mutator, or assembler of the immunoglobulin mutasome?Mismatch-mediated error prone repair at the immunoglobulin genes.Known components of the immunoglobulin A:T mutational machinery are intact in Burkitt lymphoma cell lines with G:C biasOn the molecular mechanism of somatic hypermutation of rearranged immunoglobulin genes.UNG shapes the specificity of AID-induced somatic hypermutation.Does DNA repair occur during somatic hypermutation?AIDing antibody diversity by error-prone mismatch repair.
P2860
Q24813835-695C5E2B-54F7-4DDC-8DA1-062960D6069FQ26830166-992916B3-AB7D-4227-A9D7-5F0C562CB842Q27000758-0A6BDB63-188B-47A4-8B2E-A945321C0E2BQ27324793-D61E68B8-E884-48FF-A98F-BF1D295B409AQ28208979-76AB3FC1-D77E-44D8-8C9B-2AA08E02FAAEQ28241953-AFED7B81-E809-4055-87A0-1A6E4BD4FFD5Q28285134-E221BDBC-7C7E-4D3F-8F81-90D8CF97CAA9Q28513507-27A1F12C-79CD-417B-AA3C-5A58B6746609Q28513971-06577D9C-7912-4B65-9C30-402465EF8D9BQ28586272-B56C0366-CF6C-4C88-B689-6E651FA4EBA9Q28589828-1A8B9AD9-B713-4E63-BEB3-FB5453C0647FQ28708807-6D867782-212F-4DC3-93DA-89C7AE754EE1Q33299999-318848E1-CC8C-47D4-B61F-58837904BEEAQ33557562-ACBAE1F0-805F-4233-A245-BEBF02F71879Q33755092-78DC0907-7C54-4C75-B3AD-5D00F43FB13DQ33770245-868EC77D-36A0-4F5E-8790-30385C532575Q33853914-5DA88180-658D-40C0-B9D3-52585FCA2B1DQ33952028-0D7E7725-AF6C-4018-92EC-0A1903E21B02Q34116350-6473604D-4E9E-4DF9-9E3E-382AF3D29E78Q34118000-F065E95A-F2E5-4B59-8DA7-A0BF38DDFE01Q34155308-AD767020-1130-4BFF-9F6F-B8B2FEE98049Q34189624-3CF12A67-A3E4-456A-B06E-3AFD3B66F04BQ34254602-392C3F1C-1392-489A-8F1E-D8A9292968B0Q34297090-D5C6E5DB-A2F1-44A7-B024-47149EC4170BQ34394298-704DB7DA-F590-41A0-BD1F-452ED2F83611Q34504886-8FE56149-F35D-4F8A-86E9-3C42BF267B07Q34595025-4F15677C-64BB-4329-B159-690B8CF80F16Q34612364-7A374CB9-5F7F-41DF-92BE-F53A10C57A99Q34695460-9D82766B-CF14-4318-B4D7-244B43449791Q34735827-91C4495F-1719-464B-AE81-2137395BA948Q34770418-4C083AE3-5A96-424B-AE38-C658D734E5B0Q34931087-34BF4E83-DC17-4A70-B9B5-E0E0C7E0DEE4Q35108519-FAB273CE-E2E4-4BD6-BF3A-A2D369935263Q35164207-BD0A8167-C6EC-4349-AABB-B0F928BD706BQ35605313-7B418DA1-6A35-4628-B9F1-CCF43D5F4ABEQ35792957-5FD7DA3F-05B3-435E-9A0E-87915F9DD1B6Q35953749-A231D25E-8273-46A3-B048-678A1989FA9AQ36118300-9896E913-A74D-44E9-B61F-8A1006CD60B3Q36173864-D134E655-2319-49D2-801E-CDD4BB43CB4EQ36173942-323326BF-E822-43E2-9E49-065D837322C6
P2860
Somatic hypermutation in MutS homologue (MSH)3-, MSH6-, and MSH3/MSH6-deficient mice reveals a role for the MSH2-MSH6 heterodimer in modulating the base substitution pattern
description
2000 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2000 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2000
@ast
im Februar 2000 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2000/02/07)
@sk
vědecký článek publikovaný v roce 2000
@cs
wetenschappelijk artikel (gepubliceerd op 2000/02/07)
@nl
наукова стаття, опублікована в лютому 2000
@uk
مقالة علمية (نشرت في 7-2-2000)
@ar
name
Somatic hypermutation in MutS ...... the base substitution pattern
@ast
Somatic hypermutation in MutS ...... the base substitution pattern
@en
Somatic hypermutation in MutS ...... the base substitution pattern
@nl
type
label
Somatic hypermutation in MutS ...... the base substitution pattern
@ast
Somatic hypermutation in MutS ...... the base substitution pattern
@en
Somatic hypermutation in MutS ...... the base substitution pattern
@nl
prefLabel
Somatic hypermutation in MutS ...... the base substitution pattern
@ast
Somatic hypermutation in MutS ...... the base substitution pattern
@en
Somatic hypermutation in MutS ...... the base substitution pattern
@nl
P2093
P2860
P921
P3181
P356
P1476
Somatic hypermutation in MutS ...... the base substitution pattern
@en
P2093
M. D. Scharff
M. Wiesendanger
W. Edelmann
P2860
P304
P3181
P356
10.1084/JEM.191.3.579
P407
P577
2000-02-07T00:00:00Z