Identification of Nile red as a fluorescent substrate of the Candida albicans ATP-binding cassette transporters Cdr1p and Cdr2p and the major facilitator superfamily transporter Mdr1p.
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Employing information theoretic measures and mutagenesis to identify residues critical for drug-proton antiport function in Mdr1p of Candida albicansA comparative study of fat storage quantitation in nematode Caenorhabditis elegans using label and label-free methodsInhibitors of the Candida albicans Major Facilitator Superfamily Transporter Mdr1p Responsible for Fluconazole ResistanceLipid droplets and peroxisomes: key players in cellular lipid homeostasis or a matter of fat--store 'em up or burn 'em down.Microbial efflux systems and inhibitors: approaches to drug discovery and the challenge of clinical implementationA high throughput flow cytometric assay platform targeting transporter inhibitionThe monoamine oxidase A inhibitor clorgyline is a broad-spectrum inhibitor of fungal ABC and MFS transporter efflux pump activities which reverses the azole resistance of Candida albicans and Candida glabrata clinical isolates.Microbial efflux pump inhibition: tactics and strategies.FK520 interacts with the discrete intrahelical amino acids of multidrug transporter Cdr1 protein and acts as antagonist to selectively chemosensitize azole-resistant clinical isolates of Candida albicans.Detection of inhibitors of Candida albicans Cdr transporters using a diS-C3(3) fluorescence.Mutational Analysis of Intracellular Loops Identify Cross Talk with Nucleotide Binding Domains of Yeast ABC Transporter Cdr1p.Rationally designed transmembrane peptide mimics of the multidrug transporter protein Cdr1 act as antagonists to selectively block drug efflux and chemosensitize azole-resistant clinical isolates of Candida albicans.A Combination Fluorescence Assay Demonstrates Increased Efflux Pump Activity as a Resistance Mechanism in Azole-Resistant Vaginal Candida albicans Isolates.The emergence of lipid droplets in yeast: current status and experimental approaches.Targeting efflux pumps to overcome antifungal drug resistance.Synthetic Organotellurium Compounds Sensitize Drug-Resistant Candida albicans Clinical Isolates to Fluconazole.Chemosensitization of multidrug resistant Candida albicans by the oxathiolone fused chalcone derivativesOptimized Nile Red efflux assay of AcrAB-TolC multidrug efflux system shows competition between substratesATP Binding Cassette C1 (ABCC1/MRP1)-mediated drug efflux contributes to disease progression in T-lineage acute lymphoblastic leukemia.Insight into pleiotropic drug resistance ATP-binding cassette pump drug transport through mutagenesis of Cdr1p transmembrane domains.Small, synthetic, GC-rich mRNA stem-loop modules 5' proximal to the AUG start-codon predictably tune gene expression in yeast.Positive regulation of the Candida albicans multidrug efflux pump Cdr1p function by phosphorylation of its N-terminal extension.Fluconazole transport into Candida albicans secretory vesicles by the membrane proteins Cdr1p, Cdr2p, and Mdr1p.Newly identified motifs in Candida albicans Cdr1 protein nucleotide binding domains are pleiotropic drug resistance subfamily-specific and functionally asymmetric.Beauvericin counteracted multi-drug resistant Candida albicans by blocking ABC transporters.Yeasts from Scarlet ibises (Eudocimus ruber): A focus on monitoring the antifungal susceptibility of Candida famata and closely related species.Cross-resistance to fluconazole induced by exposure to the agricultural azole tetraconazole: an environmental resistance school?Role of three Cryptococcus neoformans and C. gattii efflux pump coding genes in response to drug treatment.In vitro effects of promethazine on cell morphology and structure and mitochondrial activity of azole-resistant Candida tropicalis.Evaluation of the fluorescent probes Nile Red and 25-NBD-cholesterol as substrates for steroid-converting oxidoreductases using pure enzymes and microorganisms.Penetrating cations induce pleiotropic drug resistance in yeast.
P2860
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P2860
Identification of Nile red as a fluorescent substrate of the Candida albicans ATP-binding cassette transporters Cdr1p and Cdr2p and the major facilitator superfamily transporter Mdr1p.
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
@pt
bilimsel makale
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scientific article published on 03 July 2009
@en
vedecký článok
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vetenskaplig artikel
@sv
videnskabelig artikel
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vědecký článek
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name
Identification of Nile red as ...... superfamily transporter Mdr1p.
@en
Identification of Nile red as ...... superfamily transporter Mdr1p.
@nl
type
label
Identification of Nile red as ...... superfamily transporter Mdr1p.
@en
Identification of Nile red as ...... superfamily transporter Mdr1p.
@nl
prefLabel
Identification of Nile red as ...... superfamily transporter Mdr1p.
@en
Identification of Nile red as ...... superfamily transporter Mdr1p.
@nl
P2093
P2860
P356
P1476
Identification of Nile red as ...... superfamily transporter Mdr1p.
@en
P2093
Ann R Holmes
Brian C Monk
Erwin Lamping
Irena Ivnitski-Steele
Larry A Sklar
Richard D Cannon
P2860
P356
10.1016/J.AB.2009.07.001
P407
P577
2009-07-03T00:00:00Z