Integrin-dependent organization and bidirectional vesicular traffic at cytotoxic immune synapses.
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Newtonian cell interactions shape natural killer cell educationCell biological steps and checkpoints in accessing NK cell cytotoxicityVisualization of cytolytic T cell differentiation and granule exocytosis with T cells from mice expressing active fluorescent granzyme BIntegrins Influence the Size and Dynamics of Signaling Microclusters in a Pyk2-dependent MannerDistinct role of rab27a in granule movement at the plasma membrane and in the cytosol of NK cellsRemodelling of cortical actin where lytic granules dock at natural killer cell immune synapses revealed by super-resolution microscopyNatural killer cell lytic granule secretion occurs through a pervasive actin network at the immune synapseThe regulated secretory pathway in CD4(+) T cells contributes to human immunodeficiency virus type-1 cell-to-cell spread at the virological synapseIL-21 enhances NK cell functions and survival in healthy and HIV-infected patients with minimal stimulation of viral replicationProteome analysis of distinct developmental stages of human natural killer (NK) cellsKinome analysis of receptor-induced phosphorylation in human natural killer cellsTwo modes of lytic granule fusion during degranulation by natural killer cellsHuman immunodeficiency virus type 1 envelope gp120-induced partial T-cell receptor signaling creates an F-actin-depleted zone in the virological synapseRapid lytic granule convergence to the MTOC in natural killer cells is dependent on dynein but not cytolytic commitment.Adhesion shapes T cells for prompt and sustained T-cell receptor signalling.Imaging of lytic granule exocytosis in CD8+ cytotoxic T lymphocytes reveals a modified form of full fusion.NDR1-Dependent Regulation of Kindlin-3 Controls High-Affinity LFA-1 Binding and Immune Synapse Organization.WASp-dependent actin cytoskeleton stability at the dendritic cell immunological synapse is required for extensive, functional T cell contacts.Synergistic signals for natural cytotoxicity are required to overcome inhibition by c-Cbl ubiquitin ligaseNavigating barriers: the challenge of directed secretion at the natural killer cell lytic immunological synapse.The synapse and cytolytic machinery of cytotoxic T cells.Decidual-secreted factors alter invasive trophoblast membrane and secreted proteins implying a role for decidual cell regulation of placentation.Cytotoxic immunological synapses.A signaling network stimulated by β2 integrin promotes the polarization of lytic granules in cytotoxic cellsInhibitory signaling blocks activating receptor clustering and induces cytoskeletal retraction in natural killer cellsSelective role of mevalonate pathway in regulating perforin but not FasL and TNFalpha release in human Natural Killer cellsNanoscale ligand spacing influences receptor triggering in T cells and NK cellsGlycan elongation beyond the mucin associated Tn antigen protects tumor cells from immune-mediated killing.Super-resolution imaging of the natural killer cell immunological synapse on a glass-supported planar lipid bilayerVAMP8-dependent fusion of recycling endosomes with the plasma membrane facilitates T lymphocyte cytotoxicity.Imaging of Cell-Cell Communication in a Vertical Orientation Reveals High-Resolution Structure of Immunological Synapse and Novel PD-1 Dynamics.The adaptor protein Crk controls activation and inhibition of natural killer cells.Human NK cell lytic granules and regulation of their exocytosisTCR clonotypes modulate the protective effect of HLA class I molecules in HIV-1 infectionIn Vivo Killing Capacity of Cytotoxic T Cells Is Limited and Involves Dynamic Interactions and T Cell Cooperativity.Fratricide of natural killer cells dressed with tumor-derived NKG2D ligand.Simultaneous TCR and CD244 signals induce dynamic downmodulation of CD244 on human antiviral T cells.Lytic granule polarization, rather than degranulation, is the preferred target of inhibitory receptors in NK cells.β2 integrin induces TCRζ-Syk-phospholipase C-γ phosphorylation and paxillin-dependent granule polarization in human NK cellsTethering of intercellular adhesion molecule on target cells is required for LFA-1-dependent NK cell adhesion and granule polarization.
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P2860
Integrin-dependent organization and bidirectional vesicular traffic at cytotoxic immune synapses.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on July 2009
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Integrin-dependent organizatio ...... at cytotoxic immune synapses.
@en
Integrin-dependent organizatio ...... at cytotoxic immune synapses.
@nl
type
label
Integrin-dependent organizatio ...... at cytotoxic immune synapses.
@en
Integrin-dependent organizatio ...... at cytotoxic immune synapses.
@nl
prefLabel
Integrin-dependent organizatio ...... at cytotoxic immune synapses.
@en
Integrin-dependent organizatio ...... at cytotoxic immune synapses.
@nl
P2093
P2860
P1433
P1476
Integrin-dependent organizatio ...... at cytotoxic immune synapses.
@en
P2093
Dongfang Liu
Eric O Long
Gaia Vasiliver-Shamis
Tobias Meckel
P2860
P304
P356
10.1016/J.IMMUNI.2009.05.009
P407
P577
2009-07-01T00:00:00Z