TACE-mediated ectodomain shedding of the type I TGF-beta receptor downregulates TGF-beta signaling.
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ADAM17 (TACE) regulates TGFβ signaling through the cleavage of vasorinDirect imaging of APP proteolysis in living cells.Genetic variants of Adam17 differentially regulate TGFβ signaling to modify vascular pathology in mice and humans.Strategies for exploring TGF-β signaling in Drosophila.Isoflurane promotes phagocytosis of apoptotic neutrophils through AMPK-mediated ADAM17/Mer signalingEctodomain shedding of TβRIII is required for TβRIII-mediated suppression of TGF-β signaling and breast cancer migration and invasion.Embelin inhibits TNF-α converting enzyme and cancer cell metastasis: molecular dynamics and experimental evidence.Overexpression of TACE and TIMP3 mRNA in head and neck cancer: association with tumour development and progression.TACE activation by MAPK-mediated regulation of cell surface dimerization and TIMP3 association.Distinctive mechanism for sustained TGF-β signaling and growth inhibition: MEK1 activation-dependent stabilization of type II TGF-β receptors.The ADAMs family of proteases: new biomarkers and therapeutic targets for cancer?Accelerated receptor shedding inhibits kidney injury molecule-1 (KIM-1)-mediated efferocytosis.ADAM17 Promotes Motility, Invasion, and Sprouting of Lymphatic Endothelial Cells.ShcA Protects against Epithelial-Mesenchymal Transition through Compartmentalized Inhibition of TGF-β-Induced Smad Activation.Regulation of TGF-β receptor activityThe TGFβ receptor-interacting protein km23-1/DYNLRB1 plays an adaptor role in TGFβ1 autoinduction via its association with Ras.Two Paralogous Tetraspanins TSP-12 and TSP-14 Function with the ADAM10 Metalloprotease SUP-17 to Promote BMP Signaling in Caenorhabditis elegansSheddomeDB: the ectodomain shedding database for membrane-bound shed markers.The insulin response integrates increased TGF-β signaling through Akt-induced enhancement of cell surface delivery of TGF-β receptors.Endothelial deletion of ADAM17 in mice results in defective remodeling of the semilunar valves and cardiac dysfunction in adults.BACE1 regulates hippocampal astrogenesis via the Jagged1-Notch pathway.Intercellular adhesion molecule 1: recent findings and new concepts involved in mammalian spermatogenesisTNFα drives pulmonary arterial hypertension by suppressing the BMP type-II receptor and altering NOTCH signalling.TGF-β: duality of function between tumor prevention and carcinogenesis.Regulated intramembrane proteolysis of the AXL receptor kinase generates an intracellular domain that localizes in the nucleus of cancer cells.IκB kinase regulation of the TPL-2/ERK MAPK pathway.Post-translational regulation of TGF-β receptor and Smad signaling.Regulated intramembrane proteolysis of the TGFβ type I receptor conveys oncogenic signals.TspanC8 Tetraspanins and A Disintegrin and Metalloprotease 10 (ADAM10) Interact via Their Extracellular Regions: EVIDENCE FOR DISTINCT BINDING MECHANISMS FOR DIFFERENT TspanC8 PROTEINS.Moonlighting proteins in cancer.TIMPs: versatile extracellular regulators in cancer.TGF-β Signaling from Receptors to Smads.Signaling Receptors for TGF-β Family Members.Signaling Cross Talk between TGF-β/Smad and Other Signaling Pathways.Soluble MMP-14 produced by bone marrow-derived stromal cells sheds epithelial endoglin modulating the migratory properties of human breast cancer cells.TRAF6 stimulates the tumor-promoting effects of TGFβ type I receptor through polyubiquitination and activation of presenilin 1.Canonical transforming growth factor-β signaling regulates disintegrin metalloprotease expression in experimental renal fibrosis via miR-29.Coated pit-mediated endocytosis of the type I transforming growth factor-β (TGF-β) receptor depends on a di-leucine family signal and is not required for signaling.TRAF6 ubiquitinates TGFβ type I receptor to promote its cleavage and nuclear translocation in cancer.Inactivation of Rab11a GTPase in Macrophages Facilitates Phagocytosis of Apoptotic Neutrophils.
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P2860
TACE-mediated ectodomain shedding of the type I TGF-beta receptor downregulates TGF-beta signaling.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on July 2009
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
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vědecký článek
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name
TACE-mediated ectodomain shedd ...... nregulates TGF-beta signaling.
@en
TACE-mediated ectodomain shedd ...... nregulates TGF-beta signaling.
@nl
type
label
TACE-mediated ectodomain shedd ...... nregulates TGF-beta signaling.
@en
TACE-mediated ectodomain shedd ...... nregulates TGF-beta signaling.
@nl
prefLabel
TACE-mediated ectodomain shedd ...... nregulates TGF-beta signaling.
@en
TACE-mediated ectodomain shedd ...... nregulates TGF-beta signaling.
@nl
P2093
P2860
P1433
P1476
TACE-mediated ectodomain shedd ...... nregulates TGF-beta signaling.
@en
P2093
Pinglong Xu
Rik Derynck
Samy Lamouille
P2860
P356
10.1016/J.MOLCEL.2009.06.018
P577
2009-07-01T00:00:00Z