Targeting Bcl-2 based on the interaction of its BH4 domain with the inositol 1,4,5-trisphosphate receptor.
about
Antagonism of Beclin 1-dependent autophagy by BCL-2 at the endoplasmic reticulum requires NAF-1Synergistic anticancer effects of the 9.2.27PE immunotoxin and ABT-737 in melanomaRole of inositol trisphosphate receptors in autophagy in DT40 cells.Multiple functions of BCL-2 family proteins.Alpha-helical destabilization of the Bcl-2-BH4-domain peptide abolishes its ability to inhibit the IP3 receptor.The BRCA1 tumor suppressor binds to inositol 1,4,5-trisphosphate receptors to stimulate apoptotic calcium release.Selective regulation of IP3-receptor-mediated Ca2+ signaling and apoptosis by the BH4 domain of Bcl-2 versus Bcl-Xl.The type 2 inositol 1,4,5-trisphosphate receptor, emerging functions for an intriguing Ca²⁺-release channel.uPAR and cathepsin B downregulation induces apoptosis by targeting calcineurin A to BAD via Bcl-2 in gliomaEndoplasmic reticulum protein BI-1 regulates Ca²⁺-mediated bioenergetics to promote autophagyBH4 domain of Bcl-2 as a novel target for cancer therapyRegulation of inositol 1,4,5-trisphosphate-induced Ca2+ release by reversible phosphorylation and dephosphorylation.Remodelling of Ca2+ transport in cancer: how it contributes to cancer hallmarks?The trans-membrane domain of Bcl-2α, but not its hydrophobic cleft, is a critical determinant for efficient IP3 receptor inhibition.Drugs targeting Bcl-2 family members as an emerging strategy in cancer.IP(3) Receptors, Mitochondria, and Ca Signaling: Implications for AgingIntracellular organelles in the saga of Ca2+ homeostasis: different molecules for different purposes?The selective BH4-domain biology of Bcl-2-family members: IP3Rs and beyond.MicroRNAs affect BCL-2 family proteins in the setting of cerebral ischemia.Bcl-2 regulation of the inositol 1,4,5-trisphosphate receptor and calcium signaling in normal and malignant lymphocytes: potential new target for cancer treatment.Deletion mutational analysis of BMRP, a pro-apoptotic protein that binds to Bcl-2.Bcl-2 and FKBP12 bind to IP3 and ryanodine receptors at overlapping sites: the complexity of protein-protein interactions for channel regulation.Mitochondrial Ca(2+) Remodeling is a Prime Factor in Oncogenic Behavior.Non-canonical roles of Bcl-2 and Bcl-xL proteins: relevance of BH4 domain.Ryanodine receptors are targeted by anti-apoptotic Bcl-XL involving its BH4 domain and Lys87 from its BH3 domainDying to protect: cell death and the control of T-cell homeostasis.Modulation of Ca2+ Signaling by Anti-apoptotic B-Cell Lymphoma 2 Proteins at the Endoplasmic Reticulum-Mitochondrial Interface.Identification of a motif in BMRP required for interaction with Bcl-2 by site-directed mutagenesis studies.A double point mutation at residues Ile14 and Val15 of Bcl-2 uncovers a role for the BH4 domain in both protein stability and function.Subcellular Localization and Dynamics of the Bcl-2 Family of Proteins.
P2860
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P2860
Targeting Bcl-2 based on the interaction of its BH4 domain with the inositol 1,4,5-trisphosphate receptor.
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年学术文章
@wuu
2008年学术文章
@zh-cn
2008年学术文章
@zh-hans
2008年学术文章
@zh-my
2008年学术文章
@zh-sg
2008年學術文章
@yue
2008年學術文章
@zh
2008年學術文章
@zh-hant
name
Targeting Bcl-2 based on the i ...... 1,4,5-trisphosphate receptor.
@en
Targeting Bcl-2 based on the i ...... 1,4,5-trisphosphate receptor.
@nl
type
label
Targeting Bcl-2 based on the i ...... 1,4,5-trisphosphate receptor.
@en
Targeting Bcl-2 based on the i ...... 1,4,5-trisphosphate receptor.
@nl
prefLabel
Targeting Bcl-2 based on the i ...... 1,4,5-trisphosphate receptor.
@en
Targeting Bcl-2 based on the i ...... 1,4,5-trisphosphate receptor.
@nl
P2093
P2860
P1476
Targeting Bcl-2 based on the i ...... l 1,4,5-trisphosphate receptor
@en
P2093
Clark W Distelhorst
Vivien C Yee
Yi-Ping Rong
P2860
P304
P356
10.1016/J.BBAMCR.2008.10.015
P407
P50
P577
2008-11-12T00:00:00Z