X-ray and NMR structure of human Bcl-xL, an inhibitor of programmed cell death - Wikidata - wikimedia - TriplyDB

X-ray and NMR structure of human Bcl-xL, an inhibitor of programmed cell death

X-ray and NMR structure of human Bcl-xL, an inhibitor of programmed cell death

http://www.wikidata.org/entity/Q27733156

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Btf, a novel death-promoting transcriptional repressor that interacts with Bcl-2-related proteins.Bax oligomerization is required for channel-forming activity in liposomes and to trigger cytochrome c release from mitochondria Structural basis of BFL-1 for its interaction with BAX and its anti-apoptotic action in mammalian and yeast cells tBID, a membrane-targeted death ligand, oligomerizes BAK to release cytochrome c MAP-1, a novel proapoptotic protein containing a BH3-like motif that associates with Bax through its Bcl-2 homology domains Bcl-rambo, a novel Bcl-2 homologue that induces apoptosis via its unique C-terminal extension Tumor necrosis factor-alpha induces Bax-Bak interaction and apoptosis, which is inhibited by adenovirus E1B 19K tBid undergoes multiple conformational changes at the membrane required for Bax activation c-Abl tyrosine kinase regulates the human Rad9 checkpoint protein in response to DNA damage Prevention of cytokine withdrawal-induced apoptosis by Mcl-1 requires interaction between Mcl-1 and Bim Functional and structural studies of the vaccinia virus virulence factor N1 reveal a Bcl-2-like anti-apoptotic protein Structural changes in the BH3 domain of SOUL protein upon interaction with the anti-apoptotic protein Bcl-xL The conserved N-terminal BH4 domain of Bcl-2 homologues is essential for inhibition of apoptosis and interaction with CED-4 Dimerization properties of human BAD. Identification of a BH-3 domain and analysis of its binding to mutant BCL-2 and BCL-XL proteins BAG-1 modulates the chaperone activity of Hsp70/Hsc70.A common binding site mediates heterodimerization and homodimerization of Bcl-2 family members Vaccinia virus N1L protein resembles a B cell lymphoma-2 (Bcl-2) family protein Vaccinia virus anti-apoptotic F1L is a novel Bcl-2-like domain-swapped dimer that binds a highly selective subset of BH3-containing death ligands Bcl-xL phosphorylation at Ser49 by polo kinase 3 during cell cycle progression and checkpoints Mutation to Bax beyond the BH3 domain disrupts interactions with pro-survival proteins and promotes apoptosis Identification of novel in vivo phosphorylation sites of the human proapoptotic protein BAD: pore-forming activity of BAD is regulated by phosphorylation MAP-1 is a mitochondrial effector of Bax.Bim: a novel member of the Bcl-2 family that promotes apoptosis Enforced dimerization of BAX results in its translocation, mitochondrial dysfunction and apoptosis Conformation of the Bax C-terminus regulates subcellular location and cell death Activation of apoptosis in vivo by a hydrocarbon-stapled BH3 helix.Microtubule-targeting drugs induce Bcl-2 phosphorylation and association with Pin1 Microtubule-targeting drugs induce bcl-2 phosphorylation and association with Pin1 Structural analysis of an eIF3 subcomplex reveals conserved interactions required for a stable and proper translation pre-initiation complex assembly Bcl-2 inhibitors: targeting mitochondrial apoptotic pathways in cancer therapy Small-molecule Bcl-2 antagonists as targeted therapy in oncology Cytosol-to-membrane redistribution of Bax and Bcl-X(L) during apoptosis Rationale for Bcl-xL/Bad peptide complex formation from structure, mutagenesis, and biophysical studies Proapoptotic BH3-only proteins trigger membrane integration of prosurvival Bcl-w and neutralize its activity BH4 domain of antiapoptotic Bcl-2 family members closes voltage-dependent anion channel and inhibits apoptotic mitochondrial changes and cell death Evidence that membrane insertion of the cytosolic domain of Bcl-xL is governed by an electrostatic mechanism The structure of Bcl-w reveals a role for the C-terminal residues in modulating biological activity A surface groove essential for viral Bcl-2 function during chronic infection in vivo.Asparaginase treatment side-effects may be due to genes with homopolymeric Asn codons (Review-Hypothesis)The role of BH3-mimetic drugs in the treatment of pediatric hepatoblastoma

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X-ray and NMR structure of human Bcl-xL, an inhibitor of programmed cell death

http://www.wikidata.org/entity/Q27733156

description

1996 nî lūn-bûn

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1996 թուականի Մայիսին հրատարակուած գիտական յօդուած

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1996 թվականի մայիսին հրատարակված գիտական հոդված

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1996年の論文

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1996年論文

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1996年論文

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1996年論文

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1996年論文

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1996年论文

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name

X-ray and NMR structure of human Bcl-xL, an inhibitor of programmed cell death

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X-ray and NMR structure of human Bcl-xL, an inhibitor of programmed cell death

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X-ray and NMR structure of human Bcl-xL, an inhibitor of programmed cell death

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type

label

X-ray and NMR structure of human Bcl-xL, an inhibitor of programmed cell death

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X-ray and NMR structure of human Bcl-xL, an inhibitor of programmed cell death

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X-ray and NMR structure of human Bcl-xL, an inhibitor of programmed cell death

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X-ray and NMR structure of human Bcl-xL, an inhibitor of programmed cell death

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X-ray and NMR structure of human Bcl-xL, an inhibitor of programmed cell death

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X-ray and NMR structure of human Bcl-xL, an inhibitor of programmed cell death

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