Nucleotide regulation of soluble guanylate cyclase substrate specificity.
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Interfacial residues promote an optimal alignment of the catalytic center in human soluble guanylate cyclase: heterodimerization is required but not sufficient for activity.Substrate specificity determinants of class III nucleotidyl cyclasesIncorporation of tyrosine and glutamine residues into the soluble guanylate cyclase heme distal pocket alters NO and O2 binding.The soluble guanylyl cyclase activator YC-1 increases intracellular cGMP and cAMP via independent mechanisms in INS-1E cellsDynamic ligand exchange in soluble guanylyl cyclase (sGC): implications for sGC regulation and desensitization.Cobinamides are novel coactivators of nitric oxide receptor that target soluble guanylyl cyclase catalytic domain.Computational exploration of the binding mode of heme-dependent stimulators into the active catalytic domain of soluble guanylate cyclase.BAY 41-2272, a soluble guanylate cyclase agonist, activates human mononuclear phagocytes.Heme-assisted S-nitrosation desensitizes ferric soluble guanylate cyclase to nitric oxideYC-1 binding to the β subunit of soluble guanylyl cyclase overcomes allosteric inhibition by the α subunit.The G-protein regulator LGN modulates the activity of the NO receptor soluble guanylate cyclaseAllosteric regulation of nucleotidyl cyclases: an emerging pharmacological target.The chemistry and biology of soluble guanylate cyclase stimulators and activators.Structures of soluble guanylate cyclase: implications for regulatory mechanisms and drug development.Structure and Activation of Soluble Guanylyl Cyclase, the Nitric Oxide Sensor.Probing soluble guanylate cyclase activation by CO and YC-1 using resonance Raman spectroscopyInsight into the rescue of oxidized soluble guanylate cyclase by the activator cinaciguat.Probing domain interactions in soluble guanylate cyclase.The Influence of Nitric Oxide on Soluble Guanylate Cyclase Regulation by Nucleotides: ROLE OF THE PSEUDOSYMMETRIC SITE.Three regulators of G protein signaling differentially affect mating, morphology and virulence in the smut fungus Ustilago maydis.Structure/function of the soluble guanylyl cyclase catalytic domain.
P2860
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P2860
Nucleotide regulation of soluble guanylate cyclase substrate specificity.
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on August 2009
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Nucleotide regulation of soluble guanylate cyclase substrate specificity.
@en
Nucleotide regulation of soluble guanylate cyclase substrate specificity.
@nl
type
label
Nucleotide regulation of soluble guanylate cyclase substrate specificity.
@en
Nucleotide regulation of soluble guanylate cyclase substrate specificity.
@nl
prefLabel
Nucleotide regulation of soluble guanylate cyclase substrate specificity.
@en
Nucleotide regulation of soluble guanylate cyclase substrate specificity.
@nl
P2093
P2860
P356
P1433
P1476
Nucleotide regulation of soluble guanylate cyclase substrate specificity.
@en
P2093
Emily R Derbyshire
Michael A Marletta
Nathaniel B Fernhoff
Sarah Deng
P2860
P304
P356
10.1021/BI900696X
P407
P577
2009-08-01T00:00:00Z