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The chemistry and biology of soluble guanylate cyclase stimulators and activators.

The chemistry and biology of soluble guanylate cyclase stimulators and activators.

http://www.wikidata.org/entity/Q38130465

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The molecular targets of approved treatments for pulmonary arterial hypertension Exploiting the Pleiotropic Antioxidant Effects of Established Drugs in Cardiovascular Disease Extending the translational potential of targeting NO/cGMP-regulated pathways in the CVS Interfacial residues promote an optimal alignment of the catalytic center in human soluble guanylate cyclase: heterodimerization is required but not sufficient for activity.Unique aspects of the developing lung circulation: structural development and regulation of vasomotor tone Riociguat: a soluble guanylate cyclase stimulator for the treatment of pulmonary hypertension.Cardioprotective effects of PKG activation by soluble GC activator, BAY 60-2770, in ischemia-reperfusion-injured rat hearts.Motion of proximal histidine and structural allosteric transition in soluble guanylate cyclase.Early Observations on the Use of Riociguat in a Large, Metropolitan Pulmonary Arterial Hypertension/Chronic Thromboembolic Pulmonary Hypertension Treatment Center.Riociguat for pulmonary arterial hypertension associated with congenital heart disease.Cardiovascular and pharmacological implications of haem-deficient NO-unresponsive soluble guanylate cyclase knock-in mice.Regulation of Neuronal Oxygen Responses in C. elegans Is Mediated through Interactions between Globin 5 and the H-NOX Domains of Soluble Guanylate Cyclases.The Soluble Guanylate Cyclase Stimulator IWP-953 Increases Conventional Outflow Facility in Mouse Eyes.Soluble guanylate cyclase as an alternative target for bronchodilator therapy in asthma Population pharmacokinetics of single-dose riociguat in patients with renal or hepatic impairment.Analysis of the brain mural cell transcriptome.Nitric oxide-induced conformational changes in soluble guanylate cyclase Structures of soluble guanylate cyclase: implications for regulatory mechanisms and drug development.Redox signaling as a therapeutic target to inhibit myofibroblast activation in degenerative fibrotic disease Chemical intervention tools to probe phosphoinositide-dependent signalling.Organic nitrates: past, present and future.The cGMP/PKG pathway as a common mediator of cardioprotection: translatability and mechanism.Nitric Oxide Regulates Skeletal Muscle Fatigue, Fiber Type, Microtubule Organization, and Mitochondrial ATP Synthesis Efficiency Through cGMP-Dependent Mechanisms.Small molecule and peptide therapies for chronic heart failure: a patent review (2011 - 2014).Structure and Activation of Soluble Guanylyl Cyclase, the Nitric Oxide Sensor.Hydrogen sulfide, an enhancer of vascular nitric oxide signaling: mechanisms and implications.The latest advances in the discovery of nitric oxide hybrid drug compounds.Haemodynamic effects of riociguat in inoperable/recurrent chronic thromboembolic pulmonary hypertension.The Influence of Nitric Oxide on Soluble Guanylate Cyclase Regulation by Nucleotides: ROLE OF THE PSEUDOSYMMETRIC SITE.Chronic intratracheal application of the soluble guanylyl cyclase stimulator BAY 41-8543 ameliorates experimental pulmonary hypertension.Regulation of soluble guanylyl cyclase redox state by hydrogen sulfide.Pharmacological HIF-inhibition attenuates postoperative adhesion formation The sGC stimulator riociguat inhibits platelet function in washed platelets but not in whole blood.The novel organic mononitrate NDHP attenuates hypertension and endothelial dysfunction in hypertensive rats.Discovery of stimulator binding to a conserved pocket in the heme domain of soluble guanylyl cyclase.Clinical Pharmacokinetic and Pharmacodynamic Profile of Riociguat.Identification of a soluble guanylate cyclase in RBCs: preserved activity in patients with coronary artery disease.Sensitization of NO-Releasing Ruthenium Complexes to Visible Light.cIMP synthesized by sGC as a mediator of hypoxic contraction of coronary arteries.cGMP Signaling and Vascular Smooth Muscle Cell Plasticity.

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The chemistry and biology of soluble guanylate cyclase stimulators and activators.

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Angewandte Chemie International Edition

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The chemistry and biology of soluble guanylate cyclase stimulators and activators.

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Alexander Straub

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Franz-Josef Mais

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Friederike Stoll

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Hartmut Schirok

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Ingo Hartung

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Joachim Mittendorf

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Markus Follmann

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Martina Schäfer

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Michael G Hahn

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Nils Griebenow

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P2860

Crystal structures of the catalytic domain of human soluble guanylate cyclase

On the activation of soluble guanylyl cyclase by nitric oxide.

NO-independent stimulators and activators of soluble guanylate cyclase: discovery and therapeutic potential

NO-independent regulatory site of direct sGC stimulators like YC-1 and BAY 41-2272

NO and CO differentially activate soluble guanylyl cyclase via a heme pivot-bend mechanism.

PAS-mediated Dimerization of Soluble Guanylyl Cyclase Revealed by Signal Transduction Histidine Kinase Domain Crystal Structure

Crystal structure of the guanylyl cyclase Cya2

Structural Basis for Inhibition of Mammalian Adenylyl Cyclase by Calcium †

Crystal structure of the signaling helix coiled-coil domain of the β1 subunit of the soluble guanylyl cyclase

Structural insights into the molecular mechanism of H-NOX activation

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9442-9462

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scholarly article

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10.1002/ANIE.201302588

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36

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52

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Johannes-Peter Stasch

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2013-08-20T00:00:00Z

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256074490

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23963798

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