Ectopic runx2 expression in mammary epithelial cells disrupts formation of normal acini structure: implications for breast cancer progression. - Wikidata - wikimedia - TriplyDB

Ectopic runx2 expression in mammary epithelial cells disrupts formation of normal acini structure: implications for breast cancer progression.

Ectopic runx2 expression in mammary epithelial cells disrupts formation of normal acini structure: implications for breast cancer progression.

http://www.wikidata.org/entity/Q37343805

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RUNX2 and the PI3K/AKT axis reciprocal activation as a driving force for tumor progression Small Molecule Inhibitor of CBFβ-RUNX Binding for RUNX Transcription Factor Driven Cancers RUNX1 and its understudied role in breast cancer Intersection of FOXO- and RUNX1-mediated gene expression programs in single breast epithelial cells during morphogenesis and tumor progression.RUNX2 correlates with subtype-specific breast cancer in a human tissue microarray, and ectopic expression of Runx2 perturbs differentiation in the mouse mammary gland.Runx1 stabilizes the mammary epithelial cell phenotype and prevents epithelial to mesenchymal transition.Research findings working with the p53 and Rb1 targeted osteosarcoma mouse model.A proteasome inhibitor, bortezomib, inhibits breast cancer growth and reduces osteolysis by downregulating metastatic genes Metastatic bone disease: role of transcription factors and future targets.Runx2 is a novel regulator of mammary epithelial cell fate in development and breast cancer ODAM Expression Inhibits Human Breast Cancer Tumorigenesis.Cancer-related ectopic expression of the bone-related transcription factor RUNX2 in non-osseous metastatic tumor cells is linked to cell proliferation and motility Targeting of Runx2 by miR-135 and miR-203 Impairs Progression of Breast Cancer and Metastatic Bone Disease.Myeloma cell-derived Runx2 promotes myeloma progression in bone.Opposing effects of Runx2 and estradiol on breast cancer cell proliferation: in vitro identification of reciprocally regulated gene signature related to clinical letrozole responsiveness Genomic promoter occupancy of runt-related transcription factor RUNX2 in Osteosarcoma cells identifies genes involved in cell adhesion and motility.Runx1 is associated with breast cancer progression in MMTV-PyMT transgenic mice and its depletion in vitro inhibits migration and invasion Expression of the IL-11 Gene in Metastatic Cells Is Supported by Runx2-Smad and Runx2-cJun Complexes Induced by TGFβ1 Regulation of breast cancer metastasis by Runx2 and estrogen signaling: the role of SNAI2.Cancer to bone: a fatal attraction.Oncogenic cooperation between PI3K/Akt signaling and transcription factor Runx2 promotes the invasive properties of metastatic breast cancer cells Silencing of RUNX2 enhances gemcitabine sensitivity of p53-deficient human pancreatic cancer AsPC-1 cells through the stimulation of TAp63-mediated cell death.Transcription factor RUNX2 up-regulates chemokine receptor CXCR4 to promote invasive and metastatic potentials of human gastric cancer.Regulation of breast cancer and bone metastasis by microRNAs Osteoblasts stimulate the osteogenic and metastatic progression of castration-resistant prostate cancer in a novel model for in vitro and in vivo studies.Runx2 activates PI3K/Akt signaling via mTORC2 regulation in invasive breast cancer cells.MicroRNA-466 inhibits tumor growth and bone metastasis in prostate cancer by direct regulation of osteogenic transcription factor RUNX2.The RUNX family in breast cancer: relationships with estrogen signaling.RUNX2 in mammary gland development and breast cancer.Runx2 promotes both osteoblastogenesis and novel osteoclastogenic signals in ST2 mesenchymal progenitor cells.Runx2 transcriptome of prostate cancer cells: insights into invasiveness and bone metastasis.Leukocyte-mediated cell dissemination and metastasis: findings from multiple types of human tumors.Vitamin D Impacts the Expression of Runx2 Target Genes and Modulates Inflammation, Oxidative Stress and Membrane Vesicle Biogenesis Gene Networks in 143B Osteosarcoma Cells.Thyroid Hormone Receptor-β (TRβ) Mediates Runt-Related Transcription Factor 2 (Runx2) Expression in Thyroid Cancer Cells: A Novel Signaling Pathway in Thyroid Cancer Nitric Oxide Up-Regulates RUNX2 in LNCaP Prostate Tumours: Implications for Tumour Growth In Vitro and In Vivo.Role of Runx2 in crosstalk between Mek/Erk and PI3K/Akt signaling in MCF-10A cells.Runx Genes in Breast Cancer and the Mammary Lineage.Bicalutamide-induced hypoxia potentiates RUNX2-mediated Bcl-2 expression resulting in apoptosis resistance Runx2 isoform I controls a panel of proinvasive genes driving aggressiveness of papillary thyroid carcinomas.Runx2 Expression as a Potential Prognostic Marker in Invasive Ductal Breast Carcinoma.

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Ectopic runx2 expression in mammary epithelial cells disrupts formation of normal acini structure: implications for breast cancer progression.

http://www.wikidata.org/entity/Q37343805

description

article científic

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article scientifique

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articolo scientifico

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artigo científico

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bilimsel makale

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scientific article published on 18 August 2009

@en

vedecký článok

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vetenskaplig artikel

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videnskabelig artikel

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vědecký článek

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name

Ectopic runx2 expression in ma ...... for breast cancer progression.

@en

Ectopic runx2 expression in ma ...... for breast cancer progression.

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type

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Ectopic runx2 expression in ma ...... for breast cancer progression.

@en

Ectopic runx2 expression in ma ...... for breast cancer progression.

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prefLabel

Ectopic runx2 expression in ma ...... for breast cancer progression.

@en

Ectopic runx2 expression in ma ...... for breast cancer progression.

@nl

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0008-5472.CAN-09-1471

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Cancer Research

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Ectopic runx2 expression in ma ...... for breast cancer progression.

@en

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Andre J van Wijnen

http://www.w3.org/2001/XMLSchema#string

Anthony N Imbalzano

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Gary S Stein

http://www.w3.org/2001/XMLSchema#string

Jacqueline Akech

http://www.w3.org/2001/XMLSchema#string

Jane B Lian

http://www.w3.org/2001/XMLSchema#string

Janet L Stein

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Jean M Underwood

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Jeffrey A Nickerson

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Jitesh Pratap

http://www.w3.org/2001/XMLSchema#string

Karen M Imbalzano

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P2860

The RUNX genes: gain or loss of function in cancer

Causal relationship between the loss of RUNX3 expression and gastric cancer

Targeted disruption of Cbfa1 results in a complete lack of bone formation owing to maturational arrest of osteoblasts

Morphogenesis and oncogenesis of MCF-10A mammary epithelial acini grown in three-dimensional basement membrane cultures

A multigenic program mediating breast cancer metastasis to bone

Reversion of the malignant phenotype of human breast cells in three-dimensional culture and in vivo by integrin blocking antibodies

c-Src and cooperating partners in human cancer.

The Runx2 osteogenic transcription factor regulates matrix metalloproteinase 9 in bone metastatic cancer cells and controls cell invasion

Haploinsufficiency of CBFA2 causes familial thrombocytopenia with propensity to develop acute myelogenous leukaemia.

Impaired intranuclear trafficking of Runx2 (AML3/CBFA1) transcription factors in breast cancer cells inhibits osteolysis in vivo.

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6807-6814

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scholarly article

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10.1158/0008-5472.CAN-09-1471

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17

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69

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2009-08-18T00:00:00Z

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19690135

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2742766

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