Molecular requirements for recognition of brain voltage-gated sodium channels by scorpion alpha-toxins.
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Mapping the receptor site for alpha-scorpion toxins on a Na+ channel voltage sensorEvolutionary Diversification of Mesobuthus -Scorpion Toxins Affecting Sodium ChannelsModular organization of α-toxins from scorpion venom mirrors domain structure of their targets, sodium channels.Scorpion venom components that affect ion-channels functionDirect evidence that scorpion α-toxins (site-3) modulate sodium channel inactivation by hindrance of voltage-sensor movementsCommon molecular determinants of tarantula huwentoxin-IV inhibition of Na+ channel voltage sensors in domains II and IVElucidation of the molecular basis of selective recognition uncovers the interaction site for the core domain of scorpion alpha-toxins on sodium channels.Solution structure of kurtoxin: a gating modifier selective for Cav3 voltage-gated Ca(2+) channelsTarget-Driven Evolution of Scorpion ToxinsStructure and function of hainantoxin-III, a selective antagonist of neuronal tetrodotoxin-sensitive voltage-gated sodium channels isolated from the Chinese bird spider Ornithoctonus hainana.Computational methods of studying the binding of toxins from venomous animals to biological ion channels: theory and applications.Characterization of a novel BmαTX47 toxin modulating sodium channels: the crucial role of expression vectors in toxin pharmacological activity.Finding new cures for neurological disorders: a possible fringe benefit of biodefense research?Wheat germ in vitro translation to produce one of the most toxic sodium channel specific toxins.Design of sodium channel ligands with defined selectivity - a case study in scorpion alpha-toxins.Target-Driven Positive Selection at Hot Spots of Scorpion Toxins Uncovers Their Potential in Design of Insecticides.
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P2860
Molecular requirements for recognition of brain voltage-gated sodium channels by scorpion alpha-toxins.
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article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 09 June 2009
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Molecular requirements for rec ...... nels by scorpion alpha-toxins.
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Molecular requirements for rec ...... nels by scorpion alpha-toxins.
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type
label
Molecular requirements for rec ...... nels by scorpion alpha-toxins.
@en
Molecular requirements for rec ...... nels by scorpion alpha-toxins.
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Molecular requirements for rec ...... nels by scorpion alpha-toxins.
@en
Molecular requirements for rec ...... nels by scorpion alpha-toxins.
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P2093
P2860
P356
P1476
Molecular requirements for rec ...... nels by scorpion alpha-toxins.
@en
P2093
Dalia Gordon
Izhar Karbat
Lior Cohen
Michael Gurevitz
Nitza Ilan
Stanislav Sokolov
William A Catterall
P2860
P304
20684-20691
P356
10.1074/JBC.M109.021303
P407
P577
2009-06-09T00:00:00Z