Mechanistic biomarkers provide early and sensitive detection of acetaminophen-induced acute liver injury at first presentation to hospital. - Wikidata - wikimedia - TriplyDB

Mechanistic biomarkers provide early and sensitive detection of acetaminophen-induced acute liver injury at first presentation to hospital.

Mechanistic biomarkers provide early and sensitive detection of acetaminophen-induced acute liver injury at first presentation to hospital.

http://www.wikidata.org/entity/Q37346819

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STAT3, a Key Parameter of Cytokine-Driven Tissue Protection during Sterile Inflammation - the Case of Experimental Acetaminophen (Paracetamol)-Induced Liver Damage The Need for Biomarkers in Diagnosis and Prognosis of Drug-Induced Liver Disease: Does Metabolomics Have Any Role?Translating extracellular microRNA into clinical biomarkers for drug-induced toxicity: from high-throughput profiling to validation microRNAs as pharmacogenomic biomarkers for drug efficacy and drug safety assessment Update on Advances in Research on Idiosyncratic Drug-Induced Liver Injury MicroRNAs in Drug-induced Liver Injury Drug Induced Liver Injury: Review with a Focus on Genetic Factors, Tissue Diagnosis, and Treatment Options Paracetamol poisoning: beyond the nomogram miR-122 is a unique molecule with great potential in diagnosis, prognosis of liver disease, and therapy both as miRNA mimic and antimir Contributions of nonhematopoietic cells and mediators to immune responses: implications for immunotoxicology Pathogenesis of idiosyncratic drug-induced liver injury and clinical perspectives.Biomarkers in DILI: One More Step Forward Single-Multiplex Detection of Organ Injury Biomarkers using SPRi based Nano-Immunosensor Retro-orbital blood acquisition facilitates circulating microRNA measurement in zebrafish with paracetamol hepatotoxicity Identification of the plasma metabolomics as early diagnostic markers between biliary atresia and neonatal hepatitis syndrome Drug-induced liver injury: recent advances in diagnosis and risk assessment.Current and future directions in the treatment and prevention of drug-induced liver injury: a systematic review.M2-like Kupffer cells in fibrotic liver may protect against acute insult.Molecular mechanism and therapeutic modulation of high mobility group box 1 release and action: an updated review.Mechanisms of acetaminophen hepatotoxicity and their translation to the human pathophysiology.Predicting risk in patients with acetaminophen overdose.Benign elevations in serum aminotransferases and biomarkers of hepatotoxicity in healthy volunteers treated with cholestyramine.Serum mitochondrial biomarkers and damage-associated molecular patterns are higher in acetaminophen overdose patients with poor outcome.Biomarkers distinguish apoptotic and necrotic cell death during hepatic ischemia/reperfusion injury in mice.Effect of the UK's revised paracetamol poisoning management guidelines on admissions, adverse reactions and costs of treatment.Glycodeoxycholic acid levels as prognostic biomarker in acetaminophen-induced acute liver failure patients HMGB1 in health and disease.Argininosuccinate synthetase as a plasma biomarker of liver injury after acetaminophen overdose in rodents and humans MD-2 is required for disulfide HMGB1-dependent TLR4 signaling.The HMGB1/RAGE axis triggers neutrophil-mediated injury amplification following necrosis.MicroRNA-122: a novel hepatocyte-enriched in vitro marker of drug-induced cellular toxicity.Bile acid-induced necrosis in primary human hepatocytes and in patients with obstructive cholestasis.Drug-induced liver injury: the dawn of biomarkers?Application of high-throughput sequencing to circulating microRNAs reveals novel biomarkers for drug-induced liver injury.Circulating microRNAs Reveal Time Course of Organ Injury in a Porcine Model of Acetaminophen-Induced Acute Liver Failure Circulating miRNAs: Potential Novel Biomarkers for Hepatopathology Progression and Diagnosis of Schistosomiasis Japonica in Two Murine Models.Evaluating the role of treatment-related toxicities in the challenges facing targeted therapies for advanced hepatocellular carcinoma.MicroRNAs as Signaling Mediators and Biomarkers of Drug- and Chemical-Induced Liver Injury.Circulating Kidney Injury Molecule 1 Predicts Prognosis and Poor Outcome in Patients With Acetaminophen-Induced Liver Injury An ongoing search for potential targets and therapies for lethal sepsis

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Mechanistic biomarkers provide early and sensitive detection of acetaminophen-induced acute liver injury at first presentation to hospital.

http://www.wikidata.org/entity/Q37346819

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bilimsel makale

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scientific article published on 02 July 2013

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Mechanistic biomarkers provide ...... irst presentation to hospital.

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Mechanistic biomarkers provide ...... irst presentation to hospital.

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Alasdair J Gray

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B Kevin Park

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Christopher E Goldring

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D Nicholas Bateman

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Daniel J Antoine

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David J Webb

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James W Dear

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Jonathan G Moggs

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Judy Coyle

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Moyra Masson

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P2860

Adverse reactions to acetylcysteine and effects of overdose

Circulating microRNAs, potential biomarkers for drug-induced liver injury

Characterization of microRNA expression profiles in normal human tissues

Monocytic cells hyperacetylate chromatin protein HMGB1 to redirect it towards secretion.

Molecular forms of HMGB1 and keratin-18 as mechanistic biomarkers for mode of cell death and prognosis during clinical acetaminophen hepatotoxicity

Staggered overdose pattern and delay to hospital presentation are associated with adverse outcomes following paracetamol-induced hepatotoxicity.

The mechanism underlying acetaminophen-induced hepatotoxicity in humans and mice involves mitochondrial damage and nuclear DNA fragmentation.

Detailed analyses of self-poisoning episodes presenting to a large regional teaching hospital in the UK.

Mechanism-based bioanalysis and biomarkers for hepatic chemical stress.

Oxidant stress, mitochondria, and cell death mechanisms in drug-induced liver injury: lessons learned from acetaminophen hepatotoxicity

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777-787

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10.1002/HEP.26294

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23390034

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