Molecular forms of HMGB1 and keratin-18 as mechanistic biomarkers for mode of cell death and prognosis during clinical acetaminophen hepatotoxicity - Wikidata - wikimedia - TriplyDB

Molecular forms of HMGB1 and keratin-18 as mechanistic biomarkers for mode of cell death and prognosis during clinical acetaminophen hepatotoxicity

Molecular forms of HMGB1 and keratin-18 as mechanistic biomarkers for mode of cell death and prognosis during clinical acetaminophen hepatotoxicity

http://www.wikidata.org/entity/Q34024427

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Drug Induced Liver Injury: Review with a Focus on Genetic Factors, Tissue Diagnosis, and Treatment Options Acetaminophen-induced Liver Injury: from Animal Models to Humans DAMPs from Cell Death to New Life Xenobiotic and Endobiotic Mediated Interactions Between the Cytochrome P450 System and the Inflammatory Response in the Liver The role of HMGB1 in the pathogenesis of inflammatory and autoimmune diseases Emerging roles for HMGB1 protein in immunity, inflammation, and cancer Pathogenesis of idiosyncratic drug-induced liver injury and clinical perspectives.Biomarkers in DILI: One More Step Forward Mass spectrometry-based approaches to targeted quantitative proteomics in cardiovascular disease Drug-induced liver injury: recent advances in diagnosis and risk assessment.Drug-induced liver injury: Advances in mechanistic understanding that will inform risk management.TLR activation regulates damage-associated molecular pattern isoforms released during pyroptosis.Molecular isoforms of high-mobility group box 1 are mechanistic biomarkers for epilepsy The many faces of HMGB1: molecular structure-functional activity in inflammation, apoptosis, and chemotaxis.M2-like Kupffer cells in fibrotic liver may protect against acute insult.Mechanisms of acetaminophen hepatotoxicity and their translation to the human pathophysiology.Benign elevations in serum aminotransferases and biomarkers of hepatotoxicity in healthy volunteers treated with cholestyramine.High mobility group box-1 (HMGB1) participates in the pathogenesis of alcoholic liver disease (ALD).Sequestering HMGB1 via DNA-conjugated beads ameliorates murine colitis Mechanisms of acetaminophen-induced cell death in primary human hepatocytes.Serum mitochondrial biomarkers and damage-associated molecular patterns are higher in acetaminophen overdose patients with poor outcome.Prenatal and perinatal analgesic exposure and autism: an ecological link Biomarkers distinguish apoptotic and necrotic cell death during hepatic ischemia/reperfusion injury in mice.Acetaminophen from liver to brain: New insights into drug pharmacological action and toxicity Ozagrel hydrochloride, a selective thromboxane A₂ synthase inhibitor, alleviates liver injury induced by acetaminophen overdose in mice.Glycodeoxycholic acid levels as prognostic biomarker in acetaminophen-induced acute liver failure patients HMGB1 in health and disease.Scottish and Newcastle antiemetic pre-treatment for paracetamol poisoning study (SNAP).Argininosuccinate synthetase as a plasma biomarker of liver injury after acetaminophen overdose in rodents and humans MD-2 is required for disulfide HMGB1-dependent TLR4 signaling.DAMP signaling is a key pathway inducing immune modulation after brain injury.The HMGB1/RAGE axis triggers neutrophil-mediated injury amplification following necrosis.Bile acid-induced necrosis in primary human hepatocytes and in patients with obstructive cholestasis.Lower susceptibility of female mice to acetaminophen hepatotoxicity: Role of mitochondrial glutathione, oxidant stress and c-jun N-terminal kinase.High systemic levels of the cytokine-inducing HMGB1 isoform secreted in severe macrophage activation syndrome.The compromise of macrophage functions by hyperoxia is attenuated by ethacrynic acid via inhibition of NF-κB-mediated release of high-mobility group box-1.Drug-induced liver injury: the dawn of biomarkers?MicroRNAs as Signaling Mediators and Biomarkers of Drug- and Chemical-Induced Liver Injury.Circulating Kidney Injury Molecule 1 Predicts Prognosis and Poor Outcome in Patients With Acetaminophen-Induced Liver Injury Acetaminophen: Dose-Dependent Drug Hepatotoxicity and Acute Liver Failure in Patients.

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P2860

Molecular forms of HMGB1 and keratin-18 as mechanistic biomarkers for mode of cell death and prognosis during clinical acetaminophen hepatotoxicity

http://www.wikidata.org/entity/Q34024427

description

2012 nî lūn-bûn

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2012 թուականի Յունուարին հրատարակուած գիտական յօդուած

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2012年の論文

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Molecular forms of HMGB1 and k ...... l acetaminophen hepatotoxicity

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Molecular forms of HMGB1 and k ...... l acetaminophen hepatotoxicity

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Molecular forms of HMGB1 and k ...... l acetaminophen hepatotoxicity

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Molecular forms of HMGB1 and k ...... l acetaminophen hepatotoxicity

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Molecular forms of HMGB1 and k ...... l acetaminophen hepatotoxicity

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J.JHEP.2011.12.019

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Journal of Hepatology

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Molecular forms of HMGB1 and k ...... l acetaminophen hepatotoxicity

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B Kevin Park

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Daniel J Antoine

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Darren G Craig

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Hartmut Jaeschke

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James W Dear

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Kenneth J Simpson

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Matthew R Sharpe

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P2860

Induction of immunological tolerance by apoptotic cells requires caspase-dependent oxidation of high-mobility group box-1 protein

Toward unraveling the complexity of simple epithelial keratins in human disease

Release of chromatin protein HMGB1 by necrotic cells triggers inflammation

High-mobility group box 1 protein (HMGB1): nuclear weapon in the immune arsenal

Monocytic cells hyperacetylate chromatin protein HMGB1 to redirect it towards secretion.

Considerations for the use of plasma cytokeratin 18 as a biomarker in pancreatic cancer.

Results of a prospective study of acute liver failure at 17 tertiary care centers in the United States.

Detection of apoptotic caspase activation in sera from patients with chronic HCV infection is associated with fibrotic liver injury.

The impact of partial manganese superoxide dismutase (SOD2)-deficiency on mitochondrial oxidant stress, DNA fragmentation and liver injury during acetaminophen hepatotoxicity.

Acetaminophen-induced hepatotoxicity in mice occurs with inhibition of activity and nitration of mitochondrial manganese superoxide dismutase

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1070-1079

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10.1016/J.JHEP.2011.12.019

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5

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Mitchell R McGill

Mitchell R McGill

Dominic P Williams

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2012-01-17T00:00:00Z

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221767901

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22266604

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