Down syndrome: from understanding the neurobiology to therapy. - Wikidata - wikimedia - TriplyDB

Down syndrome: from understanding the neurobiology to therapy.

Down syndrome: from understanding the neurobiology to therapy.

http://www.wikidata.org/entity/Q37347649

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Molecular underpinnings of prefrontal cortex development in rodents provide insights into the etiology of neurodevelopmental disorders GABAA receptor subtypes: Therapeutic potential in Down syndrome, affective disorders, schizophrenia, and autism.Deficits in human trisomy 21 iPSCs and neurons.Abnormal microRNA expression in Ts65Dn hippocampus and whole blood: contributions to Down syndrome phenotypes.SNaPshot Assay in Quantitative Detection of Allelic Nondisjunction in Down Syndrome.DYRK1A protein kinase promotes quiescence and senescence through DREAM complex assembly.Galantamine improves olfactory learning in the Ts65Dn mouse model of Down syndrome.Disruption of neurogenesis and cortical development in transgenic mice misexpressing Olig2, a gene in the Down syndrome critical region The chromatin-binding protein HMGN1 regulates the expression of methyl CpG-binding protein 2 (MECP2) and affects the behavior of mice Mouse models for Down syndrome-associated developmental cognitive disabilities Education of a child neurologist: developmental neuroscience relevant to child neurology.Assessing Specific Cognitive Deficits Associated with Dementia in Older Adults with Down Syndrome: Use and Validity of the Arizona Cognitive Test Battery (ACTB)Gene expression changes in the MAPK pathway in both Fragile X and Down syndrome human neural progenitor cells.Deficits in cognition and synaptic plasticity in a mouse model of Down syndrome ameliorated by GABAB receptor antagonists.Neurofibromatosis, Down's syndrome, and acquired abnormalities.Short-term treatment with the GABAA receptor antagonist pentylenetetrazole produces a sustained pro-cognitive benefit in a mouse model of Down's syndrome.Systematic reanalysis of partial trisomy 21 cases with or without Down syndrome suggests a small region on 21q22.13 as critical to the phenotype.New insights into the troubles of aneuploidy Disinhibition, an emerging pharmacology of learning and memory The contribution of GABAergic dysfunction to neurodevelopmental disorders.Chromosome therapy: Potential strategies for the correction of severe chromosome aberrations.Outcome Measures for Clinical Trials in Down Syndrome.Integrated Transcriptome Map Highlights Structural and Functional Aspects of the Normal Human Heart Effects of a genetic counseling model on mothers of children with down syndrome: a Brazilian pilot study.Partial duplication of chromosome 19 associated with syndromic duane retraction syndrome.A Randomized, Double-Blind, Placebo-Controlled, Phase II Study of Oral ELND005 (scyllo-Inositol) in Young Adults with Down Syndrome without Dementia.GABAA receptor subunit deregulation in the hippocampus of human foetuses with Down syndrome.Touchscreen learning deficits in Ube3a, Ts65Dn and Mecp2 mouse models of neurodevelopmental disorders with intellectual disabilities.Overexpression of the DYRK1A Gene (Dual-Specificity Tyrosine Phosphorylation-Regulated Kinase 1A) Induces Alterations of the Serotoninergic and Dopaminergic Processing in Murine Brain Tissues.Cognitive impairments in adult mice with constitutive inactivation of RIP140 gene expression.Spatial organization of chromosome territories in the interphase nucleus of trisomy 21 cells.Partial chromosome 7 duplication with a phenotype mimicking the HOXA1 spectrum disorder.Plasma and urinary metabolomic profiles of Down syndrome correlate with alteration of mitochondrial metabolism.Down syndrome and neurofibromatosis: a case report.Emerging Roles of DYRK Kinases in Embryogenesis and Hedgehog Pathway Control.Integrated Quantitative Transcriptome Maps of Human Trisomy 21 Tissues and Cells.Transcriptome analysis of genetically matched human induced pluripotent stem cells disomic or trisomic for chromosome 21.Survey of Human Chromosome 21 Gene Expression Effects on Early Development in Danio rerio.

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P2860

Down syndrome: from understanding the neurobiology to therapy.

http://www.wikidata.org/entity/Q37347649

description

2010 nî lūn-bûn

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2010年の論文

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2010年学术文章

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2010年学术文章

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2010年学术文章

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2010年學術文章

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2010年學術文章

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2010年學術文章

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name

Down syndrome: from understanding the neurobiology to therapy.

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Down syndrome: from understanding the neurobiology to therapy.

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type

label

Down syndrome: from understanding the neurobiology to therapy.

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Down syndrome: from understanding the neurobiology to therapy.

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prefLabel

Down syndrome: from understanding the neurobiology to therapy.

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Down syndrome: from understanding the neurobiology to therapy.

@nl

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JNEUROSCI.3728-10.2010

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Journal of Neuroscience

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Down syndrome: from understanding the neurobiology to therapy.

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Ira T Lott

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Katheleen Gardiner

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Roger H Reeves

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P2860

The functional nature of synaptic circuitry is altered in area CA3 of the hippocampus in a mouse model of Down's syndrome

Chromosome 21 and down syndrome: from genomics to pathophysiology

A mouse model of Down syndrome trisomic for all human chromosome 21 syntenic regions.

Deficiencies in the region syntenic to human 21q22.3 cause cognitive deficits in mice.

Impairments in motor coordination without major changes in cerebellar plasticity in the Tc1 mouse model of Down syndrome

A chromosome 21 critical region does not cause specific Down syndrome phenotypes.

Failed retrograde transport of NGF in a mouse model of Down's syndrome: reversal of cholinergic neurodegenerative phenotypes following NGF infusion.

An aneuploid mouse strain carrying human chromosome 21 with Down syndrome phenotypes.

Alterations of neocortical pyramidal cell phenotype in the Ts65Dn mouse model of Down syndrome: effects of environmental enrichment.

Genotype-phenotype correlations in Down syndrome identified by array CGH in 30 cases of partial trisomy and partial monosomy chromosome 21

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14943-14945

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10.1523/JNEUROSCI.3728-10.2010

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45

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Mara Dierssen Sotos

Stylianos Antonarakis

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47742543

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