Inducible transcription of five globin genes in K562 human leukemia cells.
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The "beta-like-globin" gene domain in human erythroid cellsGlobin gene expression in erythroid human fetal liver cellsPurification, characterization, and cDNA cloning of an AU-rich element RNA-binding protein, AUF1The LIM protein FHL3 binds basic Krüppel-like factor/Krüppel-like factor 3 and its co-repressor C-terminal-binding protein 2Physical and functional association of cortactin with Syk in human leukemic cell line K562Pathway and gene-set activation measurement from mRNA expression data: the tissue distribution of human pathways.A negative cis-element regulates the level of enhancement by hypersensitive site 2 of the beta-globin locus control region.The role of trans-acting factors and DNA-bending in the silencing of human beta-globin gene expression.A new class of repression modules is critical for heme regulation of the yeast transcriptional activator Hap1.Developmental stage differences in chromatin subdomains of the beta-globin locus.Quantitative analysis of globin gene induction in single human erythroleukemic cells.Stable gene transfer and tissue-specific expression of a human globin gene using adenoviral vectors.Specific repression of beta-globin promoter activity by nuclear ferritinDifferential expression of human globin genes introduced in K562 cells.Mechanism for fetal globin gene expression: role of the soluble guanylate cyclase-cGMP-dependent protein kinase pathway.Cooperative activities of hematopoietic regulators recruit RNA polymerase II to a tissue-specific chromatin domain.Identification of a transcriptional silencer in the 5'-flanking region of the human epsilon-globin gene.Localization and characterization of the DNase I-hypersensitive site II (HS II) enhancer. A critical regulatory element within the beta-globin locus-activating region.Induction of terminal differentiation in human K562 erythroleukemia cells by arabinofuranosylcytosine.DNA replication facilitates the action of transcriptional enhancers in transient expression assays.Dual promoter activation by the human beta-globin locus control region.Beta-globin gene promoter generates 5' truncated transcripts in the embryonic/fetal erythroid environmentTrans acting regulation of beta globin gene expression in erythroleukemia (K562) cells.Characterization of an unique RNA initiated immediately upstream from human alpha 1 globin gene in vivo and in vitro: polymerase II-dependence, tissue specificity, and subcellular location.Activation of the human beta-globin promoter in K562 cells by DNA sequences 5' to the fetal gamma- or embryonic zeta-globin genes.A 46 base pair enhancer sequence within the locus activating region is required for induced expression of the gamma-globin gene during erythroid differentiation.A common protein binds to two silencers 5' to the human beta-globin gene.Synergism between hypersensitive sites confers long-range gene activation by the beta-globin locus control region.Genome-wide mapping of autonomous promoter activity in human cellsA beta-globin gene, inactive in the K562 leukemic cell, functions normally in a heterologous expression systemCRISPR-Cas9 epigenome editing enables high-throughput screening for functional regulatory elements in the human genome.Highly specific epigenome editing by CRISPR-Cas9 repressors for silencing of distal regulatory elementsEssential role of NF-E2 in remodeling of chromatin structure and transcriptional activation of the epsilon-globin gene in vivo by 5' hypersensitive site 2 of the beta-globin locus control regionTranscription of the HS2 enhancer toward a cis-linked gene is independent of the orientation, position, and distance of the enhancer relative to the gene.Regulation of c-myc mRNA stability in vitro by a labile destabilizer with an essential nucleic acid component.Poly(A) shortening and degradation of the 3' A+U-rich sequences of human c-myc mRNA in a cell-free system.Developmental programs of human erythroleukemia cells: globin gene expression and methylation.Histone mRNA degradation in vivo: the first detectable step occurs at or near the 3' terminusAutogenous regulation of histone mRNA decay by histone proteins in a cell-free systemErythroleukemia (K562) cells contain a functional beta-globin gene
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Inducible transcription of five globin genes in K562 human leukemia cells.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on September 1983
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Inducible transcription of five globin genes in K562 human leukemia cells.
@en
Inducible transcription of five globin genes in K562 human leukemia cells.
@nl
type
label
Inducible transcription of five globin genes in K562 human leukemia cells.
@en
Inducible transcription of five globin genes in K562 human leukemia cells.
@nl
prefLabel
Inducible transcription of five globin genes in K562 human leukemia cells.
@en
Inducible transcription of five globin genes in K562 human leukemia cells.
@nl
P2093
P2860
P356
P1476
Inducible transcription of five globin genes in K562 human leukemia cells.
@en
P2093
P2860
P304
P356
10.1073/PNAS.80.18.5515
P407
P577
1983-09-01T00:00:00Z