Functional study of the P32T ITPA variant associated with drug sensitivity in humans.
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Structural and functional characterization of a noncanonical nucleoside triphosphate pyrophosphatase fromThermotoga maritimaThe human ITPA polymorphic variant P32T is destabilized by the unpacking of the hydrophobic coreDefects in purine nucleotide metabolism lead to substantial incorporation of xanthine and hypoxanthine into DNA and RNAA disease spectrum for ITPA variation: advances in biochemical and clinical researchGLiMMPS: robust statistical model for regulatory variation of alternative splicing using RNA-seq data.Association between IPTA gene polymorphisms and hematological abnormalities in hepatitis C virus-infected patients receiving combination therapy.Role of ITPA gene polymorphism in ribavirin-induced anemia and thrombocytopenia in Egyptian patients with chronic hepatitis C.Erythrocyte inosine triphosphatase activity is decreased in HIV-seropositive individuals.Pivotal role of inosine triphosphate pyrophosphatase in maintaining genome stability and the prevention of apoptosis in human cells.Variants in the ITPA gene protect against ribavirin-induced hemolytic anemia and decrease the need for ribavirin dose reductionRole of genetic polymorphisms in hepatitis C virus chronic infection.Several factors including ITPA polymorphism influence ribavirin-induced anemia in chronic hepatitis C.The ITPA and C20orf194 Polymorphisms and Hematological Changes During Treatment With Pegylated-Interferon Plus Ribavirin in Patients With Chronic Hepatitis C.Association of ITPA polymorphism with outcomes of peginterferon-α plus ribavirin combination therapy.Deoxyinosine triphosphate induces MLH1/PMS2- and p53-dependent cell growth arrest and DNA instability in mammalian cellsITPA (inosine triphosphate pyrophosphatase): from surveillance of nucleotide pools to human disease and pharmacogeneticsModulation of mutagenesis in eukaryotes by DNA replication fork dynamics and quality of nucleotide pools.Individualization of chronic hepatitis C treatment according to the host characteristics.Genetic polymorphism of inosine-triphosphate-pyrophosphatase influences mercaptopurine metabolism and toxicity during treatment of acute lymphoblastic leukemia individualized for thiopurine-S-methyl-transferase status.Inosine triphosphate pyrophosphatase 94C>A polymorphism: clinical implications for patients with systemic lupus erythematosus treated with azathioprine.Translating pharmacogenetics into clinical practice: interleukin (IL)28B and inosine triphosphatase (ITPA) polymophisms in hepatitis C virus (HCV) infection.The role of pharmacogenetics in the treatment of chronic hepatitis C infection.Review article: genetic factors that modify the outcome of viral hepatitis.Preventive DNA repair by sanitizing the cellular (deoxy)nucleoside triphosphate pool.Elevated Levels of DNA Strand Breaks Induced by a Base Analog in the Human Cell Line with the P32T ITPA Variant.The relationship between ITPA rs1127354 polymorphisms and efficacy of antiviral treatment in Northeast Chinese CHC patients.Variant Inosine Triphosphatase Phenotypes Are Associated With Increased Ribavirin Triphosphate Levels.Recessive ITPA mutations cause an early infantile encephalopathy.Quantitative in vitro and in vivo characterization of the human P32T mutant ITPase.Single and combined IL28B, ITPA and SLC28A3 host genetic markers modulating response to anti-hepatitis C therapy.Measuring deaminated nucleotide surveillance enzyme ITPA activity with an ATP-releasing nucleotide chimera.Erythrocyte Inosine triphosphatase activity: A potential biomarker for adverse events during combination antiretroviral therapy for HIV.Influence of ITPA polymorphisms on decreases of hemoglobin during treatment with pegylated interferon, ribavirin, and telaprevir.
P2860
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P2860
Functional study of the P32T ITPA variant associated with drug sensitivity in humans.
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
@pt
bilimsel makale
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scientific article published on 23 July 2009
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Functional study of the P32T ITPA variant associated with drug sensitivity in humans.
@en
Functional study of the P32T ITPA variant associated with drug sensitivity in humans.
@nl
type
label
Functional study of the P32T ITPA variant associated with drug sensitivity in humans.
@en
Functional study of the P32T ITPA variant associated with drug sensitivity in humans.
@nl
prefLabel
Functional study of the P32T ITPA variant associated with drug sensitivity in humans.
@en
Functional study of the P32T ITPA variant associated with drug sensitivity in humans.
@nl
P2093
P2860
P50
P1476
Functional study of the P32T ITPA variant associated with drug sensitivity in humans
@en
P2093
Carol Kolar
Christin Frahm
Elena R Tarakhovskaya
Gloria E O Borgstahl
Luis A Marky
Peter D Simone
Youri I Pavlov
P2860
P304
P356
10.1016/J.JMB.2009.07.051
P407
P577
2009-07-23T00:00:00Z