CD2AP and Cbl-3/Cbl-c constitute a critical checkpoint in the regulation of ret signal transduction.

CD2AP and Cbl-3/Cbl-c constitute a critical checkpoint in the regulation of ret signal transduction.

Item
http://www.wikidata.org/entity/Q37352330
Complementary genetic screens identify the E3 ubiquitin ligase CBLC, as a modifier of PARP inhibitor sensitivity.GDNF-Ret signaling in midbrain dopaminergic neurons and its implication for Parkinson diseaseEnigma prevents Cbl-c-mediated ubiquitination and degradation of RETMEN2ADifferential Recognition Preferences of the Three Src Homology 3 (SH3) Domains from the Adaptor CD2-associated Protein (CD2AP) and Direct Association with Ras and Rab Interactor 3 (RIN3).CD2-associated protein (CD2AP) enhances casitas B lineage lymphoma-3/c (Cbl-3/c)-mediated Ret isoform-specific ubiquitination and degradation via its amino-terminal Src homology 3 domains.The N terminus of Cbl-c regulates ubiquitin ligase activity by modulating affinity for the ubiquitin-conjugating enzyme.Genetic model system studies of the development of the enteric nervous system, gut motility and Hirschsprung's diseaseCbl-c ubiquitin ligase activity is increased via the interaction of its RING finger domain with a LIM domain of the paxillin homolog, Hic 5.Ret is critical for podocyte survival following glomerular injury in vivo.Positive autoregulation of GDNF levels in the ventral tegmental area mediates long-lasting inhibition of excessive alcohol consumptionThe Adaptor Protein CD2AP Is a Coordinator of Neurotrophin Signaling-Mediated Axon Arbor Plasticity.Proteomic analysis of the slit diaphragm complex: CLIC5 is a protein critical for podocyte morphology and function.
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CD2AP and Cbl-3/Cbl-c constitute a critical checkpoint in the regulation of ret signal transduction.

Item
http://www.wikidata.org/entity/Q37352330
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on August 2008
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
CD2AP and Cbl-3/Cbl-c constitu ...... on of ret signal transduction.
@en
CD2AP and Cbl-3/Cbl-c constitu ...... on of ret signal transduction.
@nl
type
label
CD2AP and Cbl-3/Cbl-c constitu ...... on of ret signal transduction.
@en
CD2AP and Cbl-3/Cbl-c constitu ...... on of ret signal transduction.
@nl
prefLabel
CD2AP and Cbl-3/Cbl-c constitu ...... on of ret signal transduction.
@en
CD2AP and Cbl-3/Cbl-c constitu ...... on of ret signal transduction.
@nl
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CD2AP and Cbl-3/Cbl-c constitu ...... on of ret signal transduction.
@en
P2093
P2860
P304
P31
P356
10.1523/JNEUROSCI.2738-08.2008
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