Retinoic acid attenuates beta-amyloid deposition and rescues memory deficits in an Alzheimer's disease transgenic mouse model. - Wikidata - wikimedia - TriplyDB

Retinoic acid attenuates beta-amyloid deposition and rescues memory deficits in an Alzheimer's disease transgenic mouse model.

Retinoic acid attenuates beta-amyloid deposition and rescues memory deficits in an Alzheimer's disease transgenic mouse model.

http://www.wikidata.org/entity/Q37352348

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Vitamin A and Alzheimer's disease Retinoids for treatment of Alzheimer's disease Emerging Link between Alzheimer's Disease and Homeostatic Synaptic Plasticity The Impact of Vitamin E and Other Fat-Soluble Vitamins on Alzheimer´s Disease Elevation of brain magnesium prevents synaptic loss and reverses cognitive deficits in Alzheimer's disease mouse model.Vitamin D2-enriched button mushroom (Agaricus bisporus) improves memory in both wild type and APPswe/PS1dE9 transgenic mice FLZ alleviates the memory deficits in transgenic mouse model of Alzheimer's disease via decreasing beta-amyloid production and tau hyperphosphorylation Significance of vitamin A to brain function, behavior and learning.Dysfunction of the RAR/RXR signaling pathway in the forebrain impairs hippocampal memory and synaptic plasticity.Computational identification of potential multitarget treatments for ameliorating the adverse effects of amyloid-β on synaptic plasticity Marginal Vitamin A Deficiency Exacerbates Memory Deficits Following Aβ1-42 Injection in Rats.Retinoic acid isomers facilitate apolipoprotein E production and lipidation in astrocytes through the retinoid X receptor/retinoic acid receptor pathway.Vitamin C deficiency increases basal exploratory activity but decreases scopolamine-induced activity in APP/PSEN1 transgenic mice Gene-environment interaction research and transgenic mouse models of Alzheimer's disease.Abnormal vibrissa-related behavior and loss of barrel field inhibitory neurons in 5xFAD transgenics.Using mice to model Alzheimer's dementia: an overview of the clinical disease and the preclinical behavioral changes in 10 mouse models Ameliorative effects of a combination of baicalin, jasminoidin and cholic acid on ibotenic acid-induced dementia model in rats.Comprehensive gene expression profiling reveals synergistic functional networks in cerebral vessels after hypertension or hypercholesterolemia.Nuclear receptors as therapeutic targets for Alzheimer's disease Baicalein alters PI3K/Akt/GSK3β signaling pathway in rats with diabetes-associated cognitive deficits Long-term treadmill exercise improves spatial memory of male APPswe/PS1dE9 mice by regulation of BDNF expression and microglia activation.Influence of isotretinoin on hippocampal-based learning in human subjects Breaking immune tolerance by targeting Foxp3(+) regulatory T cells mitigates Alzheimer's disease pathology All-trans-retinoic acid reduces BACE1 expression under inflammatory conditions via modulation of nuclear factor κB (NFκB) signaling.SCM-198 Ameliorates Cognitive Deficits, Promotes Neuronal Survival and Enhances CREB/BDNF/TrkB Signaling without Affecting Aβ Burden in AβPP/PS1 Mice.Toxicity in rat primary neurons through the cellular oxidative stress induced by the turn formation at positions 22 and 23 of Aβ42.Amelioration of cognitive impairments in APPswe/PS1dE9 mice is associated with metabolites alteration induced by total salvianolic acid.L-Stepholidine rescues memory deficit and synaptic plasticity in models of Alzheimer's disease via activating dopamine D1 receptor/PKA signaling pathway.Retinol (Vitamin A) Increases α-Synuclein, β-Amyloid Peptide, Tau Phosphorylation and RAGE Content in Human SH-SY5Y Neuronal Cell Line.Molecular Signaling Mechanisms of Natural and Synthetic Retinoids for Inhibition of Pathogenesis in Alzheimer's Disease.Target- and mechanism-based therapeutics for neurodegenerative diseases: strength in numbers Comprehensive behavioral characterization of an APP/PS-1 double knock-in mouse model of Alzheimer's disease Retinoic acid-elicited RARα/RXRα signaling attenuates Aβ production by directly inhibiting γ-secretase-mediated cleavage of amyloid precursor protein Antioxidants and cognitive training interact to affect oxidative stress and memory in APP/PSEN1 mice.Genetics of Alzheimer's disease: recent advances.Drug repositioning: an opportunity to develop novel treatments for Alzheimer's disease.The role of CYP26 enzymes in retinoic acid clearance.RanBP9 overexpression accelerates loss of pre and postsynaptic proteins in the APΔE9 transgenic mouse brain.Towards retinoid therapy for Alzheimer's disease.All-trans retinoic acid as a novel therapeutic strategy for Alzheimer's disease

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Retinoic acid attenuates beta-amyloid deposition and rescues memory deficits in an Alzheimer's disease transgenic mouse model.

http://www.wikidata.org/entity/Q37352348

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2008 nî lūn-bûn

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Retinoic acid attenuates beta- ...... isease transgenic mouse model.

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Retinoic acid attenuates beta- ...... isease transgenic mouse model.

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Retinoic acid attenuates beta- ...... isease transgenic mouse model.

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JNEUROSCI.3153-08.2008

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Journal of Neuroscience

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Retinoic acid attenuates beta- ...... disease transgenic mouse model

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Aimin Qiao

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Eun-Sook Lee

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Guo-Huang Fan

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J Shawn Goodwin

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Matthew Allsbrook

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Yun Ding

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Ziqing Wang

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Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE

Tau pathology in Alzheimer disease and other tauopathies

Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo

Mutant presenilins specifically elevate the levels of the 42 residue beta-amyloid peptide in vivo: evidence for augmentation of a 42-specific gamma secretase

Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein

Tau is phosphorylated by GSK-3 at several sites found in Alzheimer disease and its biological activity markedly inhibited only after it is prephosphorylated by A-kinase

New phosphorylation sites identified in hyperphosphorylated tau (paired helical filament-tau) from Alzheimer's disease brain using nanoelectrospray mass spectrometry

Abeta-induced inflammatory processes in microglia cells of APP23 transgenic mice

Retinoic acid inhibits expression of TNF-alpha and iNOS in activated rat microglia

Anti-inflammatory roles of retinoic acid in rat brain astrocytes: Suppression of interferon-gamma-induced JAK/STAT phosphorylation

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11622-11634

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10.1523/JNEUROSCI.3153-08.2008

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45

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Michael P. McDonald

Michelle L. Block

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2008-11-01T00:00:00Z

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247840195

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18987198

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Alzheimer's disease

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3844785

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