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Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein

Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein

http://www.wikidata.org/entity/Q28260479

about

A myristoylated calcium-binding protein that preferentially interacts with the Alzheimer's disease presenilin 2 protein Vitamin A and Alzheimer's disease Presenilin 2 interacts with sorcin, a modulator of the ryanodine receptor Presenilin 1 is linked with gamma-secretase activity in the detergent solubilized state Substitution of a glycogen synthase kinase-3beta phosphorylation site in presenilin 1 separates presenilin function from beta-catenin signaling Molecular cloning and characterization of CALP/KChIP4, a novel EF-hand protein interacting with presenilin 2 and voltage-gated potassium channel subunit Kv4 Presenilin-1 regulates the expression of p62 to govern p62-dependent tau degradation Regulated intramembrane proteolysis of Bri2 (Itm2b) by ADAM10 and SPPL2a/SPPL2b Presenilins form ER Ca2+ leak channels, a function disrupted by familial Alzheimer's disease-linked mutations Familial Alzheimer disease-linked mutations specifically disrupt Ca2+ leak function of presenilin 1 Autosomal recessive hypercholesterolemia protein interacts with and regulates the cell surface level of Alzheimer's amyloid beta precursor protein Mammalian APH-1 interacts with presenilin and nicastrin and is required for intramembrane proteolysis of amyloid-beta precursor protein and Notch SEL-10 interacts with presenilin 1, facilitates its ubiquitination, and alters A-beta peptide production Analysis of transcriptional modulation of the presenilin 1 gene promoter by ZNF237, a candidate binding partner of the Ets transcription factor ERM Syntaxin 5 interacts with presenilin holoproteins, but not with their N- or C-terminal fragments, and affects beta-amyloid peptide production Association of gamma-secretase with lipid rafts in post-Golgi and endosome membranes.Specific inhibition of CBP/beta-catenin interaction rescues defects in neuronal differentiation caused by a presenilin-1 mutation.Presenilin-1 uses phospholipase D1 as a negative regulator of beta-amyloid formation.Presenilin-mediated transmembrane cleavage is required for Notch signal transduction in Drosophila The Notch ligand Delta1 is sequentially cleaved by an ADAM protease and gamma-secretase When loss is gain: reduced presenilin proteolytic function leads to increased Abeta42/Abeta40. Talking Point on the role of presenilin mutations in Alzheimer disease Loss-of-function presenilin mutations in Alzheimer disease. Talking Point on the role of presenilin mutations in Alzheimer disease The presenilins Inactivation of presenilins causes pre-synaptic impairment prior to post-synaptic dysfunction Conditional forebrain inactivation of nicastrin causes progressive memory impairment and age-related neurodegeneration Deletion of Mint proteins decreases amyloid production in transgenic mouse models of Alzheimer's disease Stepping closer to treating Alzheimer's disease patients with BACE1 inhibitor drugs Alzheimer's Disease and Hippocampal Adult Neurogenesis; Exploring Shared Mechanisms Molecular Mechanisms in the Pathogenesis of Alzheimer's disease and Tauopathies-Prion-Like Seeded Aggregation and Phosphorylation The amyloid hypothesis of Alzheimer's disease at 25 years Emerging Link between Alzheimer's Disease and Homeostatic Synaptic Plasticity Diverse molecular targets for therapeutic strategies in Alzheimer's disease Insights into the physiological function of the β-amyloid precursor protein: beyond Alzheimer's disease Protease regulation: the Yin and Yang of neural development and disease Toward the structure of presenilin/γ-secretase and presenilin homologs Functional O-GlcNAc modifications: implications in molecular regulation and pathophysiology The genetics of Alzheimer disease Autoinhibition of Mint1 adaptor protein regulates amyloid precursor protein binding and processing Three-dimensional structure of human γ-secretase Lysosome and calcium dysregulation in Alzheimer's disease: partners in crime

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P2860

Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein

http://www.wikidata.org/entity/Q28260479

description

1998 nî lūn-bûn

@nan

1998 թուականի Յունուարին հրատարակուած գիտական յօդուած

@hyw

1998 թվականի հունվարին հրատարակված գիտական հոդված

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1998年の論文

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1998年論文

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1998年論文

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1998年論文

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1998年論文

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1998年論文

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1998年论文

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name

Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein

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Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein

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Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein

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type

label

Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein

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Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein

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Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein

@nl

prefLabel

Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein

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Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein

@en

Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein

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1053079917

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