Gas6 deficiency increases oligodendrocyte loss and microglial activation in response to cuprizone-induced demyelination.
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The Gas6/TAM System and Multiple SclerosisPhagocytosis of apoptotic cells in homeostasisPolymorphisms in the receptor tyrosine kinase MERTK gene are associated with multiple sclerosis susceptibilityHistological validation of fast macromolecular proton fraction mapping as a quantitative myelin imaging method in the cuprizone demyelination modelAssociation of plasma levels of Protein S with disease severity in multiple sclerosis.GAS6 enhances repair following cuprizone-induced demyelination.Gas6 increases myelination by oligodendrocytes and its deficiency delays recovery following cuprizone-induced demyelinationNeurobiology of microglial action in CNS injuries: receptor-mediated signaling mechanisms and functional rolesTAM receptor tyrosine kinases: expression, disease and oncogenesis in the central nervous system.Involvement of receptor tyrosine kinase Tyro3 in amyloidogenic APP processing and β-amyloid deposition in Alzheimer's disease models.Targeted GAS6 delivery to the CNS protects axons from damage during experimental autoimmune encephalomyelitisInvestigation of sequential growth factor delivery during cuprizone challenge in mice aimed to enhance oligodendrogliogenesis and myelin repair.High expression of long intervening non-coding RNA OLMALINC in the human cortical white matter is associated with regulation of oligodendrocyte maturationLoss of the receptor tyrosine kinase Axl leads to enhanced inflammation in the CNS and delayed removal of myelin debris during experimental autoimmune encephalomyelitisTissue inhibitor of metalloproteinases-3 mediates the death of immature oligodendrocytes via TNF-α/TACE in focal cerebral ischemia in miceTAM receptor deficiency affects adult hippocampal neurogenesis.Demyelination and remyelination in anatomically distinct regions of the corpus callosum following cuprizone intoxicationTAM receptor signaling in immune homeostasis.Common and Low Frequency Variants in MERTK Are Independently Associated with Multiple Sclerosis Susceptibility with Discordant Association Dependent upon HLA-DRB1*15:01 Status.Involvement of the Tyro3 receptor and its intracellular partner Fyn signaling in Schwann cell myelinationGas6-Tyro3 signaling is required for Schwann cell myelination and possible remyelination.Vitamin K and the nervous system: an overview of its actions.The emerging threat of superwarfarins: history, detection, mechanisms, and countermeasures.Phagocytosis executes delayed neuronal death after focal brain ischemia.Up-regulation of soluble Axl and Mer receptor tyrosine kinases negatively correlates with Gas6 in established multiple sclerosis lesionsGlial response during cuprizone-induced de- and remyelination in the CNS: lessons learned.Primary phagocytosis of neurons by inflamed microglia: potential roles in neurodegenerationVitamin K, an emerging nutrient in brain function.Phagocyte dysfunction, tissue aging and degeneration.Microglial phagocytosis of live neurons.Transcriptomic profiling of astrocytes treated with the Rho kinase inhibitor fasudil reveals cytoskeletal and pro-survival responses.Locomotor activity and anxiety status, but not spatial working memory, are affected in mice after brief exposure to cuprizone.MerTK Is a Functional Regulator of Myelin Phagocytosis by Human Myeloid Cells.The Long-Lasting Rodenticide Brodifacoum Induces Neuropathology in Adult Male Rats.The TAM receptor Tyro3 regulates myelination in the central nervous system.Puma, but not noxa is essential for oligodendroglial cell death.Loss of Gas6 and Axl signaling results in extensive axonal damage, motor deficits, prolonged neuroinflammation, and less remyelination following cuprizone exposure.Therapeutic warfarin use and the extrahepatic functions of vitamin K-dependent proteins.Cuprizone-Containing Pellets Are Less Potent to Induce Consistent Demyelination in the Corpus Callosum of C57BL/6 Mice.Galanin is an autocrine myelin and oligodendrocyte trophic signal induced by leukemia inhibitory factor.
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Gas6 deficiency increases oligodendrocyte loss and microglial activation in response to cuprizone-induced demyelination.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on May 2008
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
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vědecký článek
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name
Gas6 deficiency increases olig ...... prizone-induced demyelination.
@en
Gas6 deficiency increases olig ...... prizone-induced demyelination.
@nl
type
label
Gas6 deficiency increases olig ...... prizone-induced demyelination.
@en
Gas6 deficiency increases olig ...... prizone-induced demyelination.
@nl
prefLabel
Gas6 deficiency increases olig ...... prizone-induced demyelination.
@en
Gas6 deficiency increases olig ...... prizone-induced demyelination.
@nl
P2093
P2860
P50
P1476
Gas6 deficiency increases olig ...... uprizone-induced demyelination
@en
P2093
Anne L Prieto
Dennis Kemper
Holly S Cate
Peter Carmeliet
Tania Cipriani
P2860
P304
P356
10.1523/JNEUROSCI.1180-08.2008
P407
P577
2008-05-01T00:00:00Z