IL-4 and IL-13 activate the JAK2 tyrosine kinase and Stat6 in cultured human vascular endothelial cells through a common pathway that does not involve the gamma c chain.
about
Sialyltransferase ST3Gal-III regulates Siglec-F ligand formation and eosinophilic lung inflammation in miceInduction of 15-lipoxygenase expression by IL-13 requires tyrosine phosphorylation of Jak2 and Tyk2 in human monocytesTh2 cells and GATA-3 in asthma: new insights into the regulation of airway inflammationInterleukin-4 and interleukin-13: their similarities and discrepancies.Human epicardium-derived cells fuse with high efficiency with skeletal myotubes and differentiate toward the skeletal muscle phenotype: a comparison study with stromal and endothelial cells.IL-13Rα1 expression on β-cell-specific T cells in NOD miceBiology and therapeutic potential of the interleukin-4/interleukin-13 signaling pathway in asthma.An immune cell-selective interleukin 4 agonist.Signal transducer and activator of transcription 6 controls chemokine production and T helper cell type 2 cell trafficking in allergic pulmonary inflammation.Signal transducer and activator of transcription factor 6 (Stat6)-deficient mice are protected from antigen-induced airway hyperresponsiveness and mucus production.Inhibition of angiogenesis by interleukin 4.Safety, tolerability and pharmacokinetics of a human anti-interleukin-13 monoclonal antibody (CNTO 5825) in an ascending single-dose first-in-human study.STAT6-mediated suppression of erythropoiesis in an experimental model of malarial anemia.Molecular and Cellular Responses to Interleukin-4 Treatment in a Rat Model of Transient Ischemia.Shared gamma(c) subunit within the human interleukin-7 receptor complex. A molecular basis for the pathogenesis of X-linked severe combined immunodeficiency.The pharmacological modulation of allergen-induced asthma.The potential for genetically altered microglia to influence glioma treatment.Genome-wide approaches reveal functional interleukin-4-inducible STAT6 binding to the vascular cell adhesion molecule 1 promoterRegulation of interleukin-13 receptor constituents on mature human B lymphocytes.Interleukin-13 induction of 15-lipoxygenase gene expression requires p38 mitogen-activated protein kinase-mediated serine 727 phosphorylation of Stat1 and Stat3.Protein-tyrosine phosphatase Shp-1 is a negative regulator of IL-4- and IL-13-dependent signal transduction.An interleukin (IL)-13 receptor lacking the cytoplasmic domain fails to transduce IL-13-induced signals and inhibits responses to IL-4.Clinical investigation of the role of interleukin-4 and interleukin-13 in the evolution of prostate cancer.Direct effects of interleukin-13 on signaling pathways for physiological responses in cultured human airway smooth muscle cells.Interleukin-13 mediates airways hyperreactivity through the IL-4 receptor-alpha chain and STAT-6 independently of IL-5 and eotaxin.Interleukin-4 signaling in B lymphocytes from patients with X-linked severe combined immunodeficiency.
P2860
Q24613558-24A2A7CF-282A-4561-91ED-A2E890D7864CQ28289279-A2AE5D97-A84D-4828-B3D2-74EEEC6CD22DQ33753434-7F4696E4-7787-479B-A601-5BE78327D086Q34488885-6A9F2213-00E3-426B-ACB3-9B47AD335256Q34611643-6EE45DA2-0955-4391-968B-4AC1FF0F3D13Q35043426-5261D9A7-5C65-4EC4-91F0-70B752DCAF1EQ35627845-1EAD5BB8-5AF7-47D9-AFCC-15C28615CC47Q36261184-64787ED3-A158-4AC5-B5E1-B8663CC72ECFQ36369328-4ADE9E47-0214-4170-9137-6F0C9FBCD91FQ36400465-DF4436DF-4843-4DA5-8211-31FFF834DE8BQ36401812-7537FEA7-31C3-4513-9FF1-ABB18DDB0D3CQ36792978-21A130E3-C5BE-4C1B-B939-4EB80509F75CQ37082704-A86919E0-7A48-4FBF-93D1-BCFB59EA4EE9Q37350621-805D9E5B-B573-4567-A494-46DA58A6D2E1Q37362415-A1C4763C-7842-42DE-9FB6-13F5C77A533FQ38055384-09DFE733-9761-4729-A1A9-D3204338A9A1Q38139120-20CC38A4-815E-4C74-92A6-C2555BF42C1FQ38336135-EA7562D9-048B-4593-8B04-942D5771CBD1Q38337458-A4F8226E-56A0-4449-8235-4610C68782DDQ39753333-D3194A27-218E-48CA-8983-BFF79A98FDCFQ40988710-C2123C7A-3888-4532-81D2-D637C41E30A9Q41091740-BC0F88E9-9AFF-4031-8992-7C61054A9DDEQ42585544-3297F981-CE89-4965-8273-3D0FC5A50BBAQ43660408-D1C8A474-739A-4B23-9AE5-362C1C6B19E6Q43789225-08067339-E5DF-45F0-BBF4-B57064C47424Q46450503-B01AF867-D1EE-4595-9ACD-0E008ED8CD0E
P2860
IL-4 and IL-13 activate the JAK2 tyrosine kinase and Stat6 in cultured human vascular endothelial cells through a common pathway that does not involve the gamma c chain.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on August 1996
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
IL-4 and IL-13 activate the JA ...... not involve the gamma c chain.
@en
IL-4 and IL-13 activate the JA ...... not involve the gamma c chain.
@nl
type
label
IL-4 and IL-13 activate the JA ...... not involve the gamma c chain.
@en
IL-4 and IL-13 activate the JA ...... not involve the gamma c chain.
@nl
prefLabel
IL-4 and IL-13 activate the JA ...... not involve the gamma c chain.
@en
IL-4 and IL-13 activate the JA ...... not involve the gamma c chain.
@nl
P2093
P2860
P356
P1476
IL-4 and IL-13 activate the JA ...... not involve the gamma c chain.
@en
P2093
C C Hughes
R L Palmer-Crocker
P2860
P304
P356
10.1172/JCI118829
P407
P577
1996-08-01T00:00:00Z