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Shikonin directly targets mitochondria and causes mitochondrial dysfunction in cancer cells.Redox-directed cancer therapeutics: molecular mechanisms and opportunitiesIntracellular ion channels and cancerPterostilbene simultaneously induced G0/G1-phase arrest and MAPK-mediated mitochondrial-derived apoptosis in human acute myeloid leukemia cell linesPyruvate dehydrogenase kinase as a potential therapeutic target for malignant gliomas.The determination and analysis of site-specific rates of mitochondrial reactive oxygen species production.The synthetic caged garcinia xanthone cluvenone induces cell stress and apoptosis and has immune modulatory activity.Preferential killing of cancer cells with mitochondrial dysfunction by natural compounds.Dietary chalcones with chemopreventive and chemotherapeutic potential.Silencing of doublecortin-like (DCL) results in decreased mitochondrial activity and delayed neuroblastoma tumor growth.Mitochondrial subversion in cancer.Subcellular localization and activity of gambogic acidShikonin inhibits IFN-γ-induced K17 over-expression of HaCaT cells by interfering with STAT3 signaling.Mitochondrial permeability transition pore as a selective target for anti-cancer therapyLanatoside C suppressed colorectal cancer cell growth by inducing mitochondrial dysfunction and increased radiation sensitivity by impairing DNA damage repair.Sites of reactive oxygen species generation by mitochondria oxidizing different substratesPterostilbene Inhibits Human Multiple Myeloma Cells via ERK1/2 and JNK Pathway In Vitro and In Vivo.Small mitochondria-targeting molecules as anti-cancer agents.An anticancer strategic dilemma: to kill or to contain. The choice of the pharmaceutical industry in 2009.Optimal choice of pH for toxicity and bioaccumulation studies of ionizing organic chemicals.Inhibitors of succinate: quinone reductase/Complex II regulate production of mitochondrial reactive oxygen species and protect normal cells from ischemic damage but induce specific cancer cell death.Mitochondria as a pharmacological target: magnum overview.The role of alpha tocopheryl succinate (α-TOS) as a potential anticancer agent.Targeting mitochondrial function for the treatment of breast cancer.Hitting the Bull's-Eye in Metastatic Cancers-NSAIDs Elevate ROS in Mitochondria, Inducing Malignant Cell Death.Association of cancer metabolism-related proteins with oral carcinogenesis - indications for chemoprevention and metabolic sensitizing of oral squamous cell carcinoma?Regulation of mitochondrial proliferation by PGC-1α induces cellular apoptosis in musculoskeletal malignancies.Effect of norcantharidin on the human breast cancer Bcap-37 cells.Cluvenone induces apoptosis via a direct target in mitochondria: a possible mechanism to circumvent chemo-resistance?The design and cytotoxic evaluation of some 1-aryl-3-isopropylamino-1-propanone hydrochlorides towards human Huh-7 hepatoma cells.Dandelion root extract affects colorectal cancer proliferation and survival through the activation of multiple death signalling pathways.API5 induces cisplatin resistance through FGFR signaling in human cancer cells.Cisplatin as an anti-tumor drug: cellular mechanisms of activity, drug resistance and induced side effectsMitochondrial respiratory chain involvement in peroxiredoxin 3 oxidation by phenethyl isothiocyanate and auranofin.Suppression of reactive oxygen species-mediated ERK and JNK activation sensitizes dihydromyricetin-induced mitochondrial apoptosis in human non-small cell lung cancer.Melatonin inhibits cholangiocarcinoma and reduces liver injury in Opisthorchis viverrini-infected and N-nitrosodimethylamine-treated hamsters.Antiproliferative effects of two gold(I)-N-heterocyclic carbene complexes in A2780 human ovarian cancer cells: a comparative proteomic study.Redox Properties and Cytotoxicity of Synthetic Isomeric Mitochondriotropic Derivatives of the Natural Polyphenol QuercetinMitochondrial Markers for Cancer: Relevance to Diagnosis, Therapy, and Prognosis and General Understanding of Malignant Disease Mechanisms
P2860
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P2860
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on January 2009
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Mitochondria as targets for cancer therapy.
@en
Mitochondria as targets for cancer therapy.
@nl
type
label
Mitochondria as targets for cancer therapy.
@en
Mitochondria as targets for cancer therapy.
@nl
prefLabel
Mitochondria as targets for cancer therapy.
@en
Mitochondria as targets for cancer therapy.
@nl
P2860
P356
P1476
Mitochondria as targets for cancer therapy.
@en
P2093
Jiri Neuzil
Stephen J Ralph
P2860
P356
10.1002/MNFR.200800044
P577
2009-01-01T00:00:00Z