Expression of human apolipoprotein A-I in transgenic mice results in reduced plasma levels of murine apolipoprotein A-I and the appearance of two new high density lipoprotein size subclasses.
about
Functional lecithin:cholesterol acyltransferase deficiency and high density lipoprotein deficiency in transgenic mice overexpressing human apolipoprotein A-IIIntestinal apolipoprotein AI gene transcription is regulated by multiple distinct DNA elements and is synergistically activated by the orphan nuclear receptor, hepatocyte nuclear factor 4Apolipoprotein B RNA editing enzyme-deficient mice are viable despite alterations in lipoprotein metabolismEvacetrapib is a novel, potent, and selective inhibitor of cholesteryl ester transfer protein that elevates HDL cholesterol without inducing aldosterone or increasing blood pressureDisruption of hyaluronan synthase-2 abrogates normal cardiac morphogenesis and hyaluronan-mediated transformation of epithelium to mesenchymeStatin-induced inhibition of the Rho-signaling pathway activates PPARalpha and induces HDL apoA-IThe cardioprotective protein apolipoprotein A1 promotes potent anti-tumorigenic effectsEvaluation of nanolipoprotein particles (NLPs) as an in vivo delivery platformHuman apoA-I expression in CETP transgenic rats leads to lower levels of apoC-I in HDL and to magnification of CETP-mediated lipoprotein changesDiscovery of biomarker candidates for coronary artery disease from an APOE-knock out mouse model using iTRAQ-based multiplex quantitative proteomics.Relationships between serum lipid, lipoprotein, triglyceride-rich lipoprotein, and high-density lipoprotein particle concentrations in post-renal transplant patients.MCP-1 deficiency reduces susceptibility to atherosclerosis in mice that overexpress human apolipoprotein B.Apo A-I inhibits foam cell formation in Apo E-deficient mice after monocyte adherence to endotheliumHDL promotes rapid atherosclerosis regression in mice and alters inflammatory properties of plaque monocyte-derived cells.Role of Esrrg in the fibrate-mediated regulation of lipid metabolism genes in human ApoA-I transgenic miceDietary fat increases high density lipoprotein (HDL) levels both by increasing the transport rates and decreasing the fractional catabolic rates of HDL cholesterol ester and apolipoprotein (Apo) A-I. Presentation of a new animal model and mechanistiHypertriglyceridemia and cholesteryl ester transfer protein interact to dramatically alter high density lipoprotein levels, particle sizes, and metabolism. Studies in transgenic miceInfluence of apolipoprotein (Apo) A-I structure on nascent high density lipoprotein (HDL) particle size distributionApolipoprotein AI transgene corrects apolipoprotein E deficiency-induced atherosclerosis in mice.Overexpression of human apolipoprotein A-I preserves cognitive function and attenuates neuroinflammation and cerebral amyloid angiopathy in a mouse model of Alzheimer disease.The impact of plasma triglyceride and apolipoproteins concentrations on high-density lipoprotein subclasses distribution.ABCG1 and HDL protect against endothelial dysfunction in mice fed a high-cholesterol diet.Bile acid-activated nuclear receptor FXR suppresses apolipoprotein A-I transcription via a negative FXR response element.Expression of human apolipoprotein B and assembly of lipoprotein(a) in transgenic mice.Intravenously injected human apolipoprotein A-I rapidly enters the central nervous system via the choroid plexus.HDL from apoA1 transgenic mice expressing the 4WF isoform is resistant to oxidative loss of functionRosuvastatin does not affect human apolipoprotein A-I expression in genetically modified mice: a clue to the disputed effect of statins on HDLAn interaction between the human cholesteryl ester transfer protein (CETP) and apolipoprotein A-I genes in transgenic mice results in a profound CETP-mediated depression of high density lipoprotein cholesterol levels.Expression of human lecithin-cholesterol acyltransferase in transgenic mice. Effect of human apolipoprotein AI and human apolipoprotein all on plasma lipoprotein cholesterol metabolismAtherogenesis in transgenic mice with human apolipoprotein B and lipoprotein (a).Decreased early atherosclerotic lesions in hypertriglyceridemic mice expressing cholesteryl ester transfer protein transgeneCholesterol efflux potential of sera from mice expressing human cholesteryl ester transfer protein and/or human apolipoprotein AIInduction of fatal inflammation in LDL receptor and ApoA-I double-knockout mice fed dietary fat and cholesterol.Human ApoA-II inhibits the hydrolysis of HDL triglyceride and the decrease of HDL size induced by hypertriglyceridemia and cholesteryl ester transfer protein in transgenic miceRed blood cells play a role in reverse cholesterol transport.Cholesterol-Independent Suppression of Lymphocyte Activation, Autoimmunity, and Glomerulonephritis by Apolipoprotein A-I in Normocholesterolemic Lupus-Prone MiceA comparison of the mouse and human lipoproteome: suitability of the mouse model for studies of human lipoproteinsTransgenic mouse models of lipoprotein metabolism and atherosclerosisSelective erythroid replacement in murine beta-thalassemia using fetal hematopoietic stem cellsThe specific amino acid sequence between helices 7 and 8 influences the binding specificity of human apolipoprotein A-I for high density lipoprotein (HDL) subclasses: a potential for HDL preferential generation
P2860
Q24312351-645D4E2E-4B60-4652-85C4-01D2C1084998Q24318945-A6D4E786-BCE9-4B7D-AF54-6865140A4DB9Q24616407-1BDAA31D-F929-43DA-A7DB-74FDA0A72839Q24624286-184042B3-9F74-495C-8722-75A6D3CD03A2Q24629543-20F91CB5-F9CB-4B2D-B6BF-09AE178D3C90Q28366335-53D79A5F-6347-4DD6-8E2B-1D2BB1D95331Q28388695-F7B7E59A-CA2E-4389-9320-3ABA940CA172Q28541661-8F046082-382F-4A71-9D04-B5849E6B1656Q28570515-582DF6AB-A6FB-4C67-AA51-DE2A4017829DQ31018798-6E04A0EF-FA73-46A5-AD83-3412F812E0E5Q33781024-555CAE1D-AB5B-4807-9BDC-F75EC92DC2C2Q33844451-10DA2F2F-1EC7-4047-986F-5FF7EF1BC9EDQ33853451-FC363EA0-D189-46A4-889F-ED4598D348A9Q33868782-2492D267-2623-4187-B03D-31013A3A6714Q33872411-16153BDC-350C-41C9-B29A-920AA351C6F6Q33896520-9DCF71FC-070C-4095-AACC-E57072557801Q33900976-78528F6D-D429-4189-9AB0-9B291BDAED99Q34186341-282F3BB8-C2B5-4B6B-9CCC-64BCB2031F01Q34229782-7AFF9C7F-FC5D-41F3-9A93-BF57DDE1FBBEQ34299310-6BCC2FDC-DBC0-49C9-B2B8-5CB9135EC47CQ34564466-4EA97392-FDC8-4A6E-913C-734C34C6C4ADQ34657417-E0512A03-A82D-4A4A-9EF4-B9DDCBA85025Q34790389-E6BB3520-74CE-4806-8478-50015A5B3B0AQ35094413-DA245803-BC0A-4A48-AC31-41B754EFE3D7Q35114943-2E3D949B-FC33-42DD-A513-D70A975363EDQ35120941-36333068-0A67-4F09-8B14-3DFBD9F85301Q35564280-4D148B59-DE29-4F0F-A0FF-886B35C9A700Q35605274-002FF2D5-D954-4183-9B47-7731116FF225Q35763106-98305131-4307-4DCF-874C-AB01BAC4197EQ35763619-2C887559-A328-4702-80E8-AD1FB1240EBCQ35765195-9702C0A8-89CA-4B33-B9C7-9D10DE053EB5Q35767755-0726993C-DCCD-4C67-9A1F-EBEC8FF14BA4Q35791953-544812EE-0F07-41ED-9A1C-0EBF88C93914Q35824669-CF4A5461-6686-47E7-A62B-E80CC604944CQ35988733-8C15A65C-62A7-462B-A5CF-9242D17CBCA2Q36260399-01C3C6FC-9593-4211-80F5-3B105286110DQ36459901-A86C33E4-07B5-4FAA-A0DB-EC8A86B84685Q36525382-B4BD6461-FAE1-445F-8358-639B077867ACQ36634704-EE85A02D-5261-42BD-A506-0934ABE1300DQ36701853-84D68F30-71A1-4113-8C43-68BA136FEC08
P2860
Expression of human apolipoprotein A-I in transgenic mice results in reduced plasma levels of murine apolipoprotein A-I and the appearance of two new high density lipoprotein size subclasses.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on January 1991
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Expression of human apolipopro ...... y lipoprotein size subclasses.
@en
Expression of human apolipopro ...... y lipoprotein size subclasses.
@nl
type
label
Expression of human apolipopro ...... y lipoprotein size subclasses.
@en
Expression of human apolipopro ...... y lipoprotein size subclasses.
@nl
prefLabel
Expression of human apolipopro ...... y lipoprotein size subclasses.
@en
Expression of human apolipopro ...... y lipoprotein size subclasses.
@nl
P2093
P2860
P356
P1476
Expression of human apolipopro ...... y lipoprotein size subclasses.
@en
P2093
P2860
P304
P356
10.1073/PNAS.88.2.434
P407
P577
1991-01-01T00:00:00Z