about
Atom-by-atom engineering of voltage-gated ion channels: magnified insights into function and pharmacologyPrinciples of agonist recognition in Cys-loop receptorsA selectivity filter at the intracellular end of the acid-sensing ion channel pore.Contributions of conserved residues at the gating interface of glycine receptors.A Conserved Residue Cluster That Governs Kinetics of ATP-dependent Gating of Kir6.2 Potassium ChannelsAtomic basis for therapeutic activation of neuronal potassium channels.Intermediate state trapping of a voltage sensorLigand-specific conformational changes in the alpha1 glycine receptor ligand-binding domainHydrogen bonds as molecular timers for slow inactivation in voltage-gated potassium channels.Magnitude of a conformational change in the glycine receptor beta1-beta2 loop is correlated with agonist efficacy.Asymmetric functional contributions of acidic and aromatic side chains in sodium channel voltage-sensor domains.Unnatural amino acids as probes of ligand-receptor interactions and their conformational consequences.Unique Contributions of an Arginine Side Chain to Ligand Recognition in a Glutamate-gated Chloride Channel.A novel mechanism for fine-tuning open-state stability in a voltage-gated potassium channel.Expression-dependent pharmacology of transient receptor potential vanilloid subtype 1 channels in Xenopus laevis oocytesContributions of counter-charge in a potassium channel voltage-sensor domain.Molecular basis for class Ib anti-arrhythmic inhibition of cardiac sodium channels.Distinct conformational changes in activated agonist-bound and agonist-free glycine receptor subunits.PIP2 mediates functional coupling and pharmacology of neuronal KCNQ channels.Conformational variability of the glycine receptor M2 domain in response to activation by different agonists.Molecular Basis for Allosteric Inhibition of Acid-Sensing Ion Channel 1a by Ibuprofen.Investigation of Agonist Recognition and Channel Properties in a Flatworm Glutamate-Gated Chloride Channel.Extracellular quaternary ammonium blockade of transient receptor potential vanilloid subtype 1 channels expressed in Xenopus laevis oocytes.The quaternary lidocaine derivative, QX-314, exerts biphasic effects on transient receptor potential vanilloid subtype 1 channels in vitro.High-Sensitivity Fluorometry to Resolve Ion Channel Conformational Dynamics.Unexplained cardiac arrest: a tale of conflicting interpretations of KCNQ1 genetic test results.One drug-sensitive subunit is sufficient for a near-maximal retigabine effect in KCNQ channels.Caught in the act: multiple binding sites for memantineIntroduction: Applying Chemical Biology to Ion ChannelsRole of an Absolutely Conserved Tryptophan Pair in the Extracellular Domain of Cys-Loop ReceptorsPhenotypic Spectrum of HCN4 Mutations: A Clinical CaseHow an intrinsic ligand tunes the activity of a potassium channelMechanism and site of action of big dynorphin on ASIC1aAcid-sensing ion channels emerged over 600 Mya and are conserved throughout the deuterostomesEvolutionarily Conserved Interactions within the Pore Domain of Acid-Sensing Ion ChannelsFour drug-sensitive subunits are required for maximal effect of a voltage sensor-targeted KCNQ openerMolecular determinants for agonist recognition and discrimination in P2X2 receptorsDeterminants of ion selectivity in ASIC1a- and ASIC2a-containing acid-sensing ion channelsChemical modification of proteins by insertion of synthetic peptides using tandem protein trans-splicingThe NALCN channel complex is voltage sensitive and directly modulated by extracellular calcium
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P50
description
hulumtues
@sq
researcher
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wetenschapper
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հետազոտող
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name
Stephan A Pless
@nl
Stephan A Pless
@sl
Stephan A. Pless
@en
Stephan A. Pless
@es
type
label
Stephan A Pless
@nl
Stephan A Pless
@sl
Stephan A. Pless
@en
Stephan A. Pless
@es
prefLabel
Stephan A Pless
@nl
Stephan A Pless
@sl
Stephan A. Pless
@en
Stephan A. Pless
@es
P106
P1153
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P21
P2798
P31
P496
0000-0001-6654-114X