Bone marrow transplantation reproduces the tristetraprolin-deficiency syndrome in recombination activating gene-2 (-/-) mice. Evidence that monocyte/macrophage progenitors may be responsible for TNFalpha overproduction.
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miR-346 controls release of TNF-α protein and stability of its mRNA in rheumatoid arthritis via tristetraprolin stabilizationThe tandem CCCH zinc finger protein tristetraprolin and its relevance to cytokine mRNA turnover and arthritisEvidence that tristetraprolin binds to AU-rich elements and promotes the deadenylation and destabilization of tumor necrosis factor alpha mRNA.Interactions of CCCH zinc finger proteins with mRNA. Binding of tristetraprolin-related zinc finger proteins to Au-rich elements and destabilization of mRNAInteractions of CCCH zinc finger proteins with mRNA: non-binding tristetraprolin mutants exert an inhibitory effect on degradation of AU-rich element-containing mRNAsCytoplasmic localization of tristetraprolin involves 14-3-3-dependent and -independent mechanismsAU-rich elements and associated factors: are there unifying principles?The roles of TTP and BRF proteins in regulated mRNA decayRegulation and localization of endogenous human tristetraprolinEpigenetic Modulators of Monocytic Function: Implication for Steady State and Disease in the CNSThe control of inflammation via the phosphorylation and dephosphorylation of tristetraprolin: a tale of two phosphatasesPhosphorylation of human tristetraprolin in response to its interaction with the Cbl interacting protein CIN85ZFP36L1 negatively regulates erythroid differentiation of CD34+ hematopoietic stem cells by interfering with the Stat5b pathwayTristetraprolin binds to the 3'-untranslated region of cyclooxygenase-2 mRNA. A polyadenylation variant in a cancer cell line lacks the binding siteAnalysis of the function, expression, and subcellular distribution of human tristetraprolinDecreased sensitivity of tristetraprolin-deficient cells to p38 inhibitors suggests the involvement of tristetraprolin in the p38 signaling pathwayCharacterization of DeltaN-Zfp36l2 mutant associated with arrest of early embryonic development and female infertilityMitogen-activated protein kinase p38 controls the expression and posttranslational modification of tristetraprolin, a regulator of tumor necrosis factor alpha mRNA stabilityMembers of the tristetraprolin family of tandem CCCH zinc finger proteins exhibit CRM1-dependent nucleocytoplasmic shuttlingRNA binding properties of the AU-rich element-binding recombinant Nup475/TIS11/tristetraprolin protein.Complex regulation and function of the inflammatory smooth muscle cell phenotype in atherosclerosisInhibition of tristetraprolin deadenylation by poly(A) binding protein.IL-17 regulates CXCL1 mRNA stability via an AUUUA/tristetraprolin-independent sequence.Tristetraprolin expression by keratinocytes controls local and systemic inflammation.Downregulation of the AU-rich RNA-binding protein ZFP36 in chronic HBV patients: implications for anti-inflammatory therapy.Immunological characterization of tristetraprolin as a low abundance, inducible, stable cytosolic proteinMyeloid ZFP36L1 does not regulate inflammation or host defense in mouse models of acute bacterial infectionPost-transcriptional regulation of gene expression by mitogen-activated protein kinase p38.Tristetraprolin (TTP) coordinately regulates primary and secondary cellular responses to proinflammatory stimuliNovel mRNA targets for tristetraprolin (TTP) identified by global analysis of stabilized transcripts in TTP-deficient fibroblasts.Post-transcriptional regulation of proinflammatory proteins.AU-rich-element-dependent translation repression requires the cooperation of tristetraprolin and RCK/P54.Negative Feed-forward Control of Tumor Necrosis Factor (TNF) by Tristetraprolin (ZFP36) Is Limited by the Mitogen-activated Protein Kinase Phosphatase, Dual-specificity Phosphatase 1 (DUSP1): IMPLICATIONS FOR REGULATION BY GLUCOCORTICOIDS.Direct binding of specific AUF1 isoforms to tandem zinc finger domains of tristetraprolin (TTP) family proteins.Myeloid-specific tristetraprolin deficiency in mice results in extreme lipopolysaccharide sensitivity in an otherwise minimal phenotype.Inhibition of toll-like receptor and cytokine signaling--a unifying theme in ischemic tolerance.Cutting edge: IL-10-mediated tristetraprolin induction is part of a feedback loop that controls macrophage STAT3 activation and cytokine production.The role of tristetraprolin in cancer and inflammation.IL-4-Stat6 signaling induces tristetraprolin expression and inhibits TNF-alpha production in mast cells.Arthritis suppressor genes TIA-1 and TTP dampen the expression of tumor necrosis factor alpha, cyclooxygenase 2, and inflammatory arthritis
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P2860
Bone marrow transplantation reproduces the tristetraprolin-deficiency syndrome in recombination activating gene-2 (-/-) mice. Evidence that monocyte/macrophage progenitors may be responsible for TNFalpha overproduction.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on September 1997
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Bone marrow transplantation re ...... e for TNFalpha overproduction.
@en
Bone marrow transplantation re ...... ecombination activating gene-2
@nl
type
label
Bone marrow transplantation re ...... e for TNFalpha overproduction.
@en
Bone marrow transplantation re ...... ecombination activating gene-2
@nl
prefLabel
Bone marrow transplantation re ...... e for TNFalpha overproduction.
@en
Bone marrow transplantation re ...... ecombination activating gene-2
@nl
P2093
P2860
P356
P1476
Bone marrow transplantation re ...... e for TNFalpha overproduction.
@en
P2093
Blackshear PJ
Carballo E
Gilkeson GS
P2860
P304
P356
10.1172/JCI119649
P407
P577
1997-09-01T00:00:00Z