Congenital hyperthyroidism caused by a solitary toxic adenoma harboring a novel somatic mutation (serine281-->isoleucine) in the extracellular domain of the thyrotropin receptor.
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How genetic errors in GPCRs affect their function: Possible therapeutic strategiesStructural-Functional Features of the Thyrotropin Receptor: A Class A G-Protein-Coupled Receptor at WorkFetal and neonatal thyrotoxicosis.Fetal neonatal hyperthyroidism: diagnostic and therapeutic approachmentA somatic gain-of-function mutation in the thyrotropin receptor gene producing a toxic adenoma in an infant.The hinge region of human thyroid-stimulating hormone (TSH) receptor operates as a tunable switch between hormone binding and receptor activation.Somatic and germline mutations of the TSH receptor and thyroid diseases.Extended and structurally supported insights into extracellular hormone binding, signal transduction and organization of the thyrotropin receptor.Defining structural and functional dimensions of the extracellular thyrotropin receptor region.Blocking type TSH receptor antibodies.Juvenile thyrotoxicosis; can we do better?The Activation Mechanism of Glycoprotein Hormone Receptors with Implications in the Cause and Therapy of Endocrine DiseasesThe thyrotropin receptor hinge region is not simply a scaffold for the leucine-rich domain but contributes to ligand binding and signal transduction.Constitutive activation of G protein-coupled receptors and diseases: insights into mechanisms of activation and therapeutics.Novel insights on thyroid-stimulating hormone receptor signal transduction.Thyroid Stimulating Hormone ReceptorTSHR as a therapeutic target in Graves' disease.The ectodomain of the luteinizing hormone receptor interacts with exoloop 2 to constrain the transmembrane region: studies using chimeric human and fly receptors.Activation of the luteinizing hormone receptor following substitution of Ser-277 with selective hydrophobic residues in the ectodomain hinge region.Significance of ectodomain cysteine boxes 2 and 3 for the activation mechanism of the thyroid-stimulating hormone receptor.Who needs thyroid function testing at birth?
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P2860
Congenital hyperthyroidism caused by a solitary toxic adenoma harboring a novel somatic mutation (serine281-->isoleucine) in the extracellular domain of the thyrotropin receptor.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on September 1997
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Congenital hyperthyroidism cau ...... n of the thyrotropin receptor.
@en
Congenital hyperthyroidism cau ...... oring a novel somatic mutation
@nl
type
label
Congenital hyperthyroidism cau ...... n of the thyrotropin receptor.
@en
Congenital hyperthyroidism cau ...... oring a novel somatic mutation
@nl
prefLabel
Congenital hyperthyroidism cau ...... n of the thyrotropin receptor.
@en
Congenital hyperthyroidism cau ...... oring a novel somatic mutation
@nl
P2093
P2860
P356
P1476
Congenital hyperthyroidism cau ...... n of the thyrotropin receptor.
@en
P2093
P2860
P304
P356
10.1172/JCI119687
P407
P577
1997-09-01T00:00:00Z