Activation of the luteinizing hormone receptor following substitution of Ser-277 with selective hydrophobic residues in the ectodomain hinge region.
about
Thyrostimulin, a heterodimer of two new human glycoprotein hormone subunits, activates the thyroid-stimulating hormone receptorStructure of follicle-stimulating hormone in complex with the entire ectodomain of its receptorH3 relaxin is a specific ligand for LGR7 and activates the receptor by interacting with both the ectodomain and the exoloop 2The role of the hinge region of the luteinizing hormone receptor in hormone interaction and signal generation.Influence of the hinge region and its adjacent domains on binding and signaling patterns of the thyrotropin and follitropin receptor.Follice-stimulating hormone receptor forms oligomers and shows evidence of carboxyl-terminal proteolytic processing.Defining structural and functional dimensions of the extracellular thyrotropin receptor region.The Activation Mechanism of Glycoprotein Hormone Receptors with Implications in the Cause and Therapy of Endocrine DiseasesStructure, function and regulation of gonadotropin receptors - a perspective.Differences in Signal Activation by LH and hCG are Mediated by the LH/CG Receptor's Extracellular Hinge RegionAsp330 and Tyr331 in the C-terminal cysteine-rich region of the luteinizing hormone receptor are key residues in hormone-induced receptor activation.Constitutive activation of G protein-coupled receptors and diseases: insights into mechanisms of activation and therapeutics.The superagonistic activity of bovine thyroid-stimulating hormone (TSH) and the human TR1401 TSH analog is determined by specific amino acids in the hinge region of the human TSH receptor.Structural and functional plasticity of the luteinizing hormone/choriogonadotrophin receptor.Model of glycoprotein hormone receptor ligand binding and signaling.The Follitropin Receptor: Matching Structure and Function.Critical involvement of the hinge region of the follicle-stimulating hormone receptor in the activation of the receptor.Identification of a novel epitope in the thyroid-stimulating hormone receptor ectodomain acting as intramolecular signaling interface.Orientation of follicle-stimulating hormone (FSH) subunits complexed with the FSH receptor. Beta subunit toward the N terminus of exodomain and alpha subunit to exoloop 3.Follicle-stimulating hormone interacts with exoloop 3 of the receptor.Two defective heterozygous luteinizing hormone receptors can rescue hormone action.The ectodomain of the luteinizing hormone receptor interacts with exoloop 2 to constrain the transmembrane region: studies using chimeric human and fly receptors.Trans-activation, cis-activation and signal selection of gonadotropin receptors.Structural requirements for mutational lutropin/choriogonadotropin receptor activation.Follitropin receptors contain cryptic ligand binding sites.A new variant in signal peptide of the human luteinizing hormone receptor (LHCGR) affects receptor biogenesis causing leydig cell hypoplasia.
P2860
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P2860
Activation of the luteinizing hormone receptor following substitution of Ser-277 with selective hydrophobic residues in the ectodomain hinge region.
description
2000 nî lūn-bûn
@nan
2000年の論文
@ja
2000年論文
@yue
2000年論文
@zh-hant
2000年論文
@zh-hk
2000年論文
@zh-mo
2000年論文
@zh-tw
2000年论文
@wuu
2000年论文
@zh
2000年论文
@zh-cn
name
Activation of the luteinizing ...... n the ectodomain hinge region.
@en
type
label
Activation of the luteinizing ...... n the ectodomain hinge region.
@en
prefLabel
Activation of the luteinizing ...... n the ectodomain hinge region.
@en
P2093
P2860
P356
P1476
Activation of the luteinizing ...... n the ectodomain hinge region.
@en
P2093
P2860
P304
30264-30271
P356
10.1074/JBC.M005568200
P407
P577
2000-09-01T00:00:00Z