Expression of protein kinase C beta in the heart causes hypertrophy in adult mice and sudden death in neonates.
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Gq/11-mediated signaling and hypertrophy in mice with cardiac-specific transgenic expression of regulator of G-protein signaling 2Protein kinase cascades in the regulation of cardiac hypertrophyProtein kinases C and D mediate agonist-dependent cardiac hypertrophy through nuclear export of histone deacetylase 5PKC translocation and ERK1/2 activation in compensated right ventricular hypertrophy secondary to chronic emphysemaProtein kinase C mechanisms that contribute to cardiac remodellingAltered focal adhesion regulation correlates with cardiomyopathy in mice expressing constitutively active rac1Transgenic incorporation of skeletal TnT into cardiac myofilaments blunts PKC-mediated depression of forcePhosphorylation or glutamic acid substitution at protein kinase C sites on cardiac troponin I differentially depress myofilament tension and shortening velocityA critical function for Ser-282 in cardiac Myosin binding protein-C phosphorylation and cardiac functionInhibition of PKC phosphorylation of cTnI improves cardiac performance in vivoThe in vivo role of p38 MAP kinases in cardiac remodeling and restrictive cardiomyopathyPKC alpha regulates the hypertrophic growth of cardiomyocytes through extracellular signal-regulated kinase1/2 (ERK1/2)Protein quality control disruption by PKCβII in heart failure; rescue by the selective PKCβII inhibitor, βIIV5-3PKCβII modulation of myocyte contractile performance.Brief rapid pacing depresses contractile function via Ca(2+)/PKC-dependent signaling in cat ventricular myocytes.Simultaneous loss of phospholipase Cδ1 and phospholipase Cδ3 causes cardiomyocyte apoptosis and cardiomyopathy.Regulation of cardiac hypertrophy in vivo by the stress-activated protein kinases/c-Jun NH(2)-terminal kinases.A positive feedback loop contributes to the deleterious effects of angiotensin.Diabetic cardiomyopathy: recent evidence from mouse models of type 1 and type 2 diabetes.Highly Specific Modulators of Protein Kinase C Localization: Applications to Heart FailureCardiac hypertrophy and failure: lessons learned from genetically engineered mice.Protein kinase Cθ is required for cardiomyocyte survival and cardiac remodeling.Calcineurin and hypertrophic heart disease: novel insights and remaining questions.Phorbol ester and endothelin-1 alter functional expression of Na+/Ca2+ exchange, K+, and Ca2+ currents in cultured neonatal rat myocytesβIIPKC and εPKC isozymes as potential pharmacological targets in cardiac hypertrophy and heart failurePKCβII inhibition attenuates myocardial infarction induced heart failure and is associated with a reduction of fibrosis and pro-inflammatory responsesLactosylceramide promotes hypertrophy through ROS generation and activation of ERK1/2 in cardiomyocytes.Preventing progression of cardiac hypertrophy and development of heart failure by paricalcitol therapy in rats.Ceramide-mediated depression in cardiomyocyte contractility through PKC activation and modulation of myofilament protein phosphorylationCardiac GPCRs: GPCR signaling in healthy and failing hearts.Distinctive activation mechanisms and functions for protein kinase Cdelta.Inhibition of Cardiac Kir Current (IK1) by Protein Kinase C Critically Depends on PKCβ and Kir2.2.Pharmacological inhibition of βIIPKC is cardioprotective in late-stage hypertrophy.Phosphoinositide 3-kinase(p110alpha) plays a critical role for the induction of physiological, but not pathological, cardiac hypertrophy.Combined cardiomyocyte PKCδ and PKCε gene deletion uncovers their central role in restraining developmental and reactive heart growthProtein kinase C depresses cardiac myocyte power output and attenuates myofilament responses induced by protein kinase ACardiac actions of protein kinase C isoformsLong-term expression of protein kinase C in adult mouse hearts improves postischemic recoveryAlteration of gene expression during progression of hypertension-induced cardiac dysfunction in rats.Agonist activated PKCβII translocation and modulation of cardiac myocyte contractile function.
P2860
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P2860
Expression of protein kinase C beta in the heart causes hypertrophy in adult mice and sudden death in neonates.
description
1997 nî lūn-bûn
@nan
1997年の論文
@ja
1997年学术文章
@wuu
1997年学术文章
@zh-cn
1997年学术文章
@zh-hans
1997年学术文章
@zh-my
1997年学术文章
@zh-sg
1997年學術文章
@yue
1997年學術文章
@zh
1997年學術文章
@zh-hant
name
Expression of protein kinase C ...... and sudden death in neonates.
@en
Expression of protein kinase C ...... and sudden death in neonates.
@nl
type
label
Expression of protein kinase C ...... and sudden death in neonates.
@en
Expression of protein kinase C ...... and sudden death in neonates.
@nl
prefLabel
Expression of protein kinase C ...... and sudden death in neonates.
@en
Expression of protein kinase C ...... and sudden death in neonates.
@nl
P2093
P2860
P356
P1476
Expression of protein kinase C ...... e and sudden death in neonates
@en
P2093
D L Geenen
J C Bowman
P M Buttrick
S F Steinberg
P2860
P304
P356
10.1172/JCI119755
P407
P577
1997-11-01T00:00:00Z