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KRIT1 regulates the homeostasis of intracellular reactive oxygen speciesThe integrin cytoplasmic domain-associated protein ICAP-1 binds and regulates Rho family GTPases during cell spreadingNuclear translocation of integrin cytoplasmic domain-associated protein 1 stimulates cellular proliferation.Expression of beta 1B integrin isoform in CHO cells results in a dominant negative effect on cell adhesion and motilityA de novo X;8 translocation creates a PTK2-THOC2 gene fusion with THOC2 expression knockdown in a patient with psychomotor retardation and congenital cerebellar hypoplasiaIdentification of the Kelch family protein Nd1-L as a novel molecular interactor of KRIT1Structural and functional differences between KRIT1A and KRIT1B isoforms: a framework for understanding CCM pathogenesis.Helicobacter pylori type IV secretion apparatus exploits beta1 integrin in a novel RGD-independent mannerThe Ras superfamily of small GTPases: the unlocked secrets.Strategy for identifying repurposed drugs for the treatment of cerebral cavernous malformation.The Interplay between ROS and Ras GTPases: Physiological and Pathological Implications.Muscle beta1D integrin reinforces the cytoskeleton-matrix link: modulation of integrin adhesive function by alternative splicing.Defective autophagy is a key feature of cerebral cavernous malformations.Cytochrome P450 and matrix metalloproteinase genetic modifiers of disease severity in Cerebral Cavernous Malformation type 1.Genetic and cellular basis of cerebral cavernous malformations: implications for clinical management.Ras GTPases are both regulators and effectors of redox agents.Cerebral cavernous malformation (CCM) disease: from monogenic forms to genetic susceptibility factors.Up-regulation of NADPH oxidase-mediated redox signaling contributes to the loss of barrier function in KRIT1 deficient endothelium.Beyond multiple mechanisms and a unique drug: Defective autophagy as pivotal player in cerebral cavernous malformation pathogenesis and implications for targeted therapies.KRIT1 loss of function causes a ROS-dependent upregulation of c-JunEvaluation of the bioactive properties of avenanthramide analogs produced in recombinant yeast.Oxidative stress and inflammation in cerebral cavernous malformation disease pathogenesis: Two sides of the same coin.Fluorescence microscopy study of Rap1 subcellular localization.Combined pulldown and time-lapse microscopy studies for determining the role of Rap1 in the crosstalk between integrins and cadherins.miR-21 coordinates tumor growth and modulates KRIT1 levels.A unique interplay between Rap1 and E-cadherin in the endocytic pathway regulates self-renewal of human embryonic stem cells.Molecular Crosstalk between Integrins and Cadherins: Do Reactive Oxygen Species Set the Talk?E-cadherin endocytosis regulates the activity of Rap1: a traffic light GTPase at the crossroads between cadherin and integrin function.Identification of Krit1B: a novel alternative splicing isoform of cerebral cavernous malformation gene-1.Integrin-induced epidermal growth factor (EGF) receptor activation requires c-Src and p130Cas and leads to phosphorylation of specific EGF receptor tyrosines.RhoA activity is required for fibronectin assembly and counteracts beta1B integrin inhibitory effect in FRT epithelial cells.The muscle-specific laminin receptor alpha7 beta1 integrin negatively regulates alpha5 beta1 fibronectin receptor function.beta1D integrin inhibits cell cycle progression in normal myoblasts and fibroblasts.Yersinia enterocolitica exploits different pathways to accomplish adhesion and toxin injection into host cells.Reactive oxygen species: friends and foes of signal transduction.Cellular processes underlying cerebral cavernous malformations: Autophagy as another point of view.Production of novel antioxidative phenolic amides through heterologous expression of the plant's chlorogenic acid biosynthesis genes in yeast.Altered expression of integrins in RSV-transformed chick epiphyseal chondrocytes.EndMT contributes to the onset and progression of cerebral cavernous malformations.Platinum nanozymes recover cellular ROS homeostasis in an oxidative stress-mediated disease model.
P50
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P50
description
hulumtues
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onderzoeker
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researcher
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հետազոտող
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name
Saverio Francesco Retta
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Saverio Francesco Retta
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Saverio Francesco Retta
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Saverio Francesco Retta
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Saverio Francesco Retta
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Saverio Francesco Retta
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Saverio Francesco Retta
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Saverio Francesco Retta
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Saverio Francesco Retta
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Saverio Francesco Retta
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Francesco Retta
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Saverio Francesco Retta
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Saverio Francesco Retta
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Saverio Francesco Retta
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Saverio Francesco Retta
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Saverio Francesco Retta
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P106
P1153
6603604351
P21
P31
P496
0000-0001-9761-2959