Control of fetal hemoglobin: new insights emerging from genomics and clinical implications.
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Genetic adaptation to high altitude in the Ethiopian highlandsHaploinsufficiency for the erythroid transcription factor KLF1 causes hereditary persistence of fetal hemoglobinMicroRNA-15a and -16-1 act via MYB to elevate fetal hemoglobin expression in human trisomy 13New insights from monogenic diabetes for "common" type 2 diabetesGenomic approaches to identifying targets for treating β hemoglobinopathiesThe potential of gene therapy approaches for the treatment of hemoglobinopathies: achievements and challengesMi2β is required for γ-globin gene silencing: temporal assembly of a GATA-1-FOG-1-Mi2 repressor complex in β-YAC transgenic miceGlobal genetic architecture of an erythroid quantitative trait locus, HMIP-2Foetal haemoglobin and the dynamics of paediatric malaria.SAR1a promoter polymorphisms are not associated with fetal hemoglobin in patients with sickle cell disease from Cameroon.Generation of a genomic reporter assay system for analysis of γ- and β-globin gene regulation.Transcriptional silencing of {gamma}-globin by BCL11A involves long-range interactions and cooperation with SOX6.A call for policy action in sub-Saharan Africa to rethink diagnostics for pregnancy affected by sickle cell disease: differential views of medical doctors, parents and adult patients predict value conflicts in Cameroon.IthaGenes: an interactive database for haemoglobin variations and epidemiologySickle cell/β0-thalassemia associated with the 1393 bp deletion can be associated with a severe phenotype.Prediction of disease and phenotype associations from genome-wide association studiesFetal globin expression is regulated by Friend of Prmt1.Genetics of fetal hemoglobin in Tanzanian and British patients with sickle cell anemia.Molecular Diagnostics of β-Thalassemia.Genetic modifiers of HbF and response to hydroxyurea in sickle cell disease.Genome wide association study of fetal hemoglobin in sickle cell anemia in Tanzania.Candidate sequence variants and fetal hemoglobin in children with sickle cell disease treated with hydroxyureaFetal hemoglobin in sickle cell anemia: genetic studies of the Arab-Indian haplotypeOxygen-Dependent Gene Expression in Development and Cancer: Lessons Learned from the Wilms' Tumor Gene, WT1MBD2 contributes to developmental silencing of the human ε-globin gene.Increased blood-oxygen binding affinity in Tibetan and Han Chinese residents at 4200 mMultiple nonglycemic genomic loci are newly associated with blood level of glycated hemoglobin in East Asians.Transcriptional regulation of fetal to adult hemoglobin switching: new therapeutic opportunities.A 3-bp deletion in the HBS1L-MYB intergenic region on chromosome 6q23 is associated with HbF expressionVasculopathy and pulmonary hypertension in sickle cell disease.Fetal hemoglobin in sickle cell anemiaA functional element necessary for fetal hemoglobin silencingVariants in genetic modifiers of β-thalassemia can help to predict the major or intermedia type of the diseaseGenetic association of fetal-hemoglobin levels in individuals with sickle cell disease in Tanzania maps to conserved regulatory elements within the MYB core enhancerFetal hemoglobin reactivation and cell engineering in the treatment of sickle cell anemia.Modulating Effect of the -158 γ (C→T) Xmn1 Polymorphism in Indian Sickle Cell Patients.Ten novel mutations in the erythroid transcription factor KLF1 gene associated with increased fetal hemoglobin levels in adults.A Novel High-Content Immunofluorescence Assay as a Tool to Identify at the Single Cell Level γ-Globin Inducing CompoundsFetal hemoglobin in sickle cell anemia: molecular characterization of the unusually high fetal hemoglobin phenotype in African Americans.Genetic modifiers of sickle cell disease
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Control of fetal hemoglobin: new insights emerging from genomics and clinical implications.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on October 2009
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Control of fetal hemoglobin: n ...... ics and clinical implications.
@en
Control of fetal hemoglobin: n ...... ics and clinical implications.
@nl
type
label
Control of fetal hemoglobin: n ...... ics and clinical implications.
@en
Control of fetal hemoglobin: n ...... ics and clinical implications.
@nl
prefLabel
Control of fetal hemoglobin: n ...... ics and clinical implications.
@en
Control of fetal hemoglobin: n ...... ics and clinical implications.
@nl
P2860
P50
P356
P1476
Control of fetal hemoglobin: n ...... ics and clinical implications.
@en
P2093
Chad Garner
P2860
P304
P356
10.1093/HMG/DDP401
P577
2009-10-01T00:00:00Z