Honokiol suppresses survival signals mediated by Ras-dependent phospholipase D activity in human cancer cells.
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Honokiol activates AMP-activated protein kinase in breast cancer cells via an LKB1-dependent pathway and inhibits breast carcinogenesisHonokiol, a multifunctional antiangiogenic and antitumor agentDesign, synthesis, and biological evaluation of halogenated N-(2-(4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-8-yl)ethyl)benzamides: discovery of an isoform-selective small molecule phospholipase D2 inhibitorEvasion of anti-growth signaling: A key step in tumorigenesis and potential target for treatment and prophylaxis by natural compounds.Design and synthesis of isoform-selective phospholipase D (PLD) inhibitors. Part I: Impact of alternative halogenated privileged structures for PLD1 specificityDesign of isoform-selective phospholipase D inhibitors that modulate cancer cell invasiveness.Selective inhibition of IFNG-induced autophagy by Mir155- and Mir31-responsive WNT5A and SHH signalingDifferent redox states in malignant and nonmalignant esophageal epithelial cells and differential cytotoxic responses to bile acid and honokiol.Cellular and physiological roles for phospholipase D1 in cancer.Phospholipase D and the maintenance of phosphatidic acid levels for regulation of mammalian target of rapamycin (mTOR)Honokiol inhibits gastric tumourigenesis by activation of 15-lipoxygenase-1 and consequent inhibition of peroxisome proliferator-activated receptor-gamma and COX-2-dependent signalsPhospholipase D signaling pathways and phosphatidic acid as therapeutic targets in cancerHeterogeneity of phosphatidic acid levels and distribution at the plasma membrane in living cells as visualized by a Föster resonance energy transfer (FRET) biosensorPreferential killing of cancer cells with mitochondrial dysfunction by natural compounds.Regulation of G1 Cell Cycle Progression: Distinguishing the Restriction Point from a Nutrient-Sensing Cell Growth Checkpoint(s)The role of phospholipase D in modulating the MTOR signaling pathway in polycystic kidney disease.Phospholipase D mediates nutrient input to mammalian target of rapamycin complex 1 (mTORC1).Phospholipase D: enzymology, functionality, and chemical modulationPaxillin phosphorylation and complexing with Erk and FAK are regulated by PLD activity in MDA-MB-231 cellsTargeting the intrinsic inflammatory pathway: honokiol exerts proapoptotic effects through STAT3 inhibition in transformed Barrett's cells.Honokiol inhibits bladder tumor growth by suppressing EZH2/miR-143 axis.Phosphatidic acid and lipid-sensing by mTORHonokiol bis-dichloroacetate (Honokiol DCA) demonstrates activity in vemurafenib-resistant melanoma in vivoRegulation of mTORC1 and mTORC2 complex assembly by phosphatidic acid: competition with rapamycin.The natural product honokiol inhibits calcineurin inhibitor-induced and Ras-mediated tumor promoting pathways.Phosphatidic acid signaling to mTOR: signals for the survival of human cancer cells.Targeting mTOR with rapamycin: one dose does not fit allTargeting phospholipase D with small-molecule inhibitors as a potential therapeutic approach for cancer metastasis.Translating cyclooxygenase signaling in patch heterozygote mice into a randomized clinical trial in basal cell carcinoma.Honokiol analogs: a novel class of anticancer agents targeting cell signaling pathways and other bioactivities.Chemical modulation of glycerolipid signaling and metabolic pathways.Inferring the Effects of Honokiol on the Notch Signaling Pathway in SW480 Colon Cancer Cells.Honokiol Induces Apoptosis, G1 Arrest, and Autophagy in KRAS Mutant Lung Cancer Cells.5-Fluoro-2-indolyl des-chlorohalopemide (FIPI), a phospholipase D pharmacological inhibitor that alters cell spreading and inhibits chemotaxis.Honokiol is a FOXM1 antagonist.Honokiol Decreases Lung Cancer Metastasis through Inhibition of the STAT3 Signaling Pathway.Quercetin Induces Antiproliferative Activity Against Human Hepatocellular Carcinoma (HepG2) Cells by Suppressing Specificity Protein 1 (Sp1).Phyto-polyphenols as potential inhibitors of breast cancer metastasis.
P2860
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P2860
Honokiol suppresses survival signals mediated by Ras-dependent phospholipase D activity in human cancer cells.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on July 2008
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
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vědecký článek
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name
Honokiol suppresses survival s ...... ctivity in human cancer cells.
@en
Honokiol suppresses survival s ...... ctivity in human cancer cells.
@nl
type
label
Honokiol suppresses survival s ...... ctivity in human cancer cells.
@en
Honokiol suppresses survival s ...... ctivity in human cancer cells.
@nl
prefLabel
Honokiol suppresses survival s ...... ctivity in human cancer cells.
@en
Honokiol suppresses survival s ...... ctivity in human cancer cells.
@nl
P2093
P2860
P1476
Honokiol suppresses survival s ...... ctivity in human cancer cells.
@en
P2093
Alfredo Toschi
Avalon Garcia
David A Foster
H Alex Brown
Jack L Arbiser
Natalie Shraibman
Yang Zheng
P2860
P304
P356
10.1158/1078-0432.CCR-08-0102
P407
P577
2008-07-01T00:00:00Z