DUX4 induces a transcriptome more characteristic of a less-differentiated cell state and inhibits myogenesis
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Ret function in muscle stem cells points to tyrosine kinase inhibitor therapy for facioscapulohumeral muscular dystrophy.Antisense Oligonucleotides Used to Target the DUX4 mRNA as Therapeutic Approaches in FaciosScapuloHumeral Muscular Dystrophy (FSHD).Estrogens enhance myoblast differentiation in facioscapulohumeral muscular dystrophy by antagonizing DUX4 activity.Expression patterns of FSHD-causing DUX4 and myogenic transcription factors PAX3 and PAX7 are spatially distinct in differentiating human stem cell culturesConservation and innovation in the DUX4-family gene network.PAX7 target genes are globally repressed in facioscapulohumeral muscular dystrophy skeletal muscle.Smchd1 haploinsufficiency exacerbates the phenotype of a transgenic FSHD1 mouse model.The DUX4 homeodomains mediate inhibition of myogenesis and are functionally exchangeable with the Pax7 homeodomain.Overexpression of the double homeodomain protein DUX4c interferes with myofibrillogenesis and induces clustering of myonuclei.Facioscapulohumeral Muscular Dystrophy.
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DUX4 induces a transcriptome more characteristic of a less-differentiated cell state and inhibits myogenesis
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on October 2016
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
DUX4 induces a transcriptome m ...... state and inhibits myogenesis
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DUX4 induces a transcriptome m ...... state and inhibits myogenesis.
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type
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DUX4 induces a transcriptome m ...... state and inhibits myogenesis
@en
DUX4 induces a transcriptome m ...... state and inhibits myogenesis.
@nl
prefLabel
DUX4 induces a transcriptome m ...... state and inhibits myogenesis
@en
DUX4 induces a transcriptome m ...... state and inhibits myogenesis.
@nl
P2093
P2860
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P1476
DUX4 induces a transcriptome m ...... state and inhibits myogenesis
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Bianca den Hamer
Christopher R S Banerji
Maryna Panamarova
Yvonne D Krom
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P304
P356
10.1242/JCS.180372
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P577
2016-10-01T00:00:00Z