Pten haploinsufficiency accelerates formation of high-grade astrocytomas - Wikidata - wikimedia - TriplyDB

Pten haploinsufficiency accelerates formation of high-grade astrocytomas

Pten haploinsufficiency accelerates formation of high-grade astrocytomas

http://www.wikidata.org/entity/Q37384874

about

Glioma oncoprotein Bcl2L12 inhibits the p53 tumor suppressor Comprehensive genomic characterization defines human glioblastoma genes and core pathways The PTEN-regulating microRNA miR-26a is amplified in high-grade glioma and facilitates gliomagenesis in vivo Treatment Algorithms Based on Tumor Molecular Profiling: The Essence of Precision Medicine Trials In vivo models of brain tumors: roles of genetically engineered mouse models in understanding tumor biology and use in preclinical studies Molecular characterizations of glioblastoma, targeted therapy, and clinical results to date MAPK pathway activation in pilocytic astrocytoma Will kinase inhibitors make it as glioblastoma drugs?PTEN degradation after ischemic stroke: a double-edged sword Sociability and motor functions in Shank1 mutant mice A restricted cell population propagates glioblastoma growth after chemotherapy Optimizing biologically targeted clinical trials for neurofibromatosis.Selective pharmacogenetic inhibition of mammalian target of Rapamycin complex I (mTORC1) blocks long-term synaptic plasticity and memory storage.Generation of cancerous neural stem cells forming glial tumor by oncogenic stimulation.FoxM1B regulates NEDD4-1 expression, leading to cellular transformation and full malignant phenotype in immortalized human astrocytes Pten loss in Olig2 expressing neural progenitor cells and oligodendrocytes leads to interneuron dysplasia and leukodystrophy.Targeting PTPRZ inhibits stem cell-like properties and tumorigenicity in glioblastoma cells.The pathobiology of glioma tumors In vivo optical imaging of brain tumors and arthritis using fluorescent SapC-DOPS nanovesicles.Cytomegalovirus contributes to glioblastoma in the context of tumor suppressor mutations.Most human non-GCIMP glioblastoma subtypes evolve from a common proneural-like precursor glioma The PTEN/PI3K/AKT Pathway in vivo, Cancer Mouse Models.Neurofibromatosis type 1: modeling CNS dysfunction.Suppression of peroxiredoxin 4 in glioblastoma cells increases apoptosis and reduces tumor growth.Cooperativity within and among Pten, p53, and Rb pathways induces high-grade astrocytoma in adult brain.Glial progenitors as targets for transformation in glioma.A preclinical orthotopic model for glioblastoma recapitulates key features of human tumors and demonstrates sensitivity to a combination of MEK and PI3K pathway inhibitors.Seeing is believing: are cancer stem cells the Loch Ness monster of tumor biology?Relationships between PTEN gene mutations and prognosis in glioma: a meta-analysis.Mechanisms of increased risk of tumorigenesis in Atm and Brca1 double heterozygosity.The impact of coexisting genetic mutations on murine optic glioma biology.Capturing the molecular and biological diversity of high-grade astrocytoma in genetically engineered mouse models Review: insights gained from modelling high-grade glioma in the mouse.Current trends in targeted therapies for glioblastoma multiforme Emerging insights into the molecular and cellular basis of glioblastoma.Small-molecule inhibition of PTPRZ reduces tumor growth in a rat model of glioblastoma.The APC/C Ubiquitin Ligase: From Cell Biology to Tumorigenesis GFAP-Cre-mediated activation of oncogenic K-ras results in expansion of the subventricular zone and infiltrating glioma Adult Lineage-Restricted CNS Progenitors Specify Distinct Glioblastoma Subtypes Spatial transcriptome analysis reveals Notch pathway-associated prognostic markers in IDH1 wild-type glioblastoma involving the subventricular zone.

P2860

Q24299628-5F03B858-478F-4689-AD63-05450834C3BB Q24656128-4662EE52-5A53-48BC-8CE4-FAC24142866C Q24657924-319B6889-3C5A-4F8F-9D38-C24FDD2E5F37 Q26776394-74520493-4DC5-477B-BD8A-B85C6DF20FC3 Q26820289-D093C7BB-23F5-4512-AA10-FCD1595F1B55 Q26822717-570D4AFE-5E8F-45EC-8951-DE221EC762B1 Q27006028-EE6CB4FB-0306-43B7-8BD7-60EE825A1B4E Q27012684-F4C2F538-7CD0-401C-8A4E-B024A8CFC2F7 Q28512531-549C4235-E439-4CBD-B977-2EAB7CAC5B96 Q28592494-532F4371-7AF2-4B9A-81DB-A71CAEE82648 Q29615605-E2850046-A77D-4B7B-B130-8B2879B2AB0D Q30438898-1E2CF50E-4F70-4DC4-AC13-86AE8FD08180 Q30476440-C72B9406-7A53-495E-BAE3-8BA88F8DC821 Q33704814-A029F101-5A6B-4E7F-9AE3-A5B685E09BD3 Q33767150-0802480B-9379-47DA-9B39-E86CC17DDC04 Q33895438-78E43E2C-C401-4551-A758-8C6666539D8C Q33912275-671AFB2B-73DA-47B7-A77A-546CFC812C60 Q33921072-54239D8C-F153-4463-AF5D-4ACAFDABB3F2 Q33995672-E974046B-A74D-499F-9D34-7AFD2315D743 Q34059848-C8A3D5A1-A646-4766-BA3A-6B43E8E5F28B Q34083282-A2AB8541-8EE4-4EBB-9A06-8CE209E3A050 Q34229795-F09F7D30-68C5-4672-9D5D-9B52AFE88395 Q34305314-674A7C84-BC8B-4F7C-9BDD-1435814A2492 Q34391054-0E76ACE9-F4DF-4055-B384-41C59DEEAA68 Q34697339-0916D7D9-3D46-419C-A5BE-0F002F708AFD Q34735661-ADD729EF-3ACD-4967-9314-2272F0C92FBC Q34818301-9D4C3C14-2F7C-4F43-9F7D-FDD12D590BF2 Q34978487-FA60F015-E336-472A-97DC-9A907CED7181 Q35140496-1A824425-21EA-4777-9E6C-53F8CE23B8A3 Q35203710-23B483B8-B141-4B68-876A-AD80A0FB2351 Q35788566-7C86979F-FA05-4206-95BB-5E51A60D4138 Q35799783-28A42551-FA5B-4A23-8C85-110F0150B3A0 Q35854724-08BC994D-0296-4B16-ACB6-FCDDA471A13A Q35864226-BD28EE88-E80C-46CC-8951-6A0EC61AE645 Q35914897-00EEFD4B-597C-40EE-ADA9-F7492A69FA57 Q35917698-9C9086D2-091F-4481-AD9D-BCB5BEC98895 Q35971862-807FC0DF-D1A4-44B2-9442-918E8BCF80DB Q36122372-920106EB-5CF6-42F8-BD97-61BF69F9EAF6 Q36168176-B82A3D9A-DE44-4101-8F23-C119E7C55642 Q36174719-6279D96F-FC2F-4471-8D37-83C7EA4EB578

P2860

Pten haploinsufficiency accelerates formation of high-grade astrocytomas

http://www.wikidata.org/entity/Q37384874

description

article científic

@ca

article scientifique

@fr

articolo scientifico

@it

artigo científico

@pt

bilimsel makale

@tr

scientific article published on May 2008

@en

vedecký článok

@sk

vetenskaplig artikel

@sv

videnskabelig artikel

@da

vědecký článek

@cs

name

Pten haploinsufficiency accelerates formation of high-grade astrocytomas

@en

Pten haploinsufficiency accelerates formation of high-grade astrocytomas.

@nl

type

label

Pten haploinsufficiency accelerates formation of high-grade astrocytomas

@en

Pten haploinsufficiency accelerates formation of high-grade astrocytomas.

@nl

prefLabel

Pten haploinsufficiency accelerates formation of high-grade astrocytomas

@en

Pten haploinsufficiency accelerates formation of high-grade astrocytomas.

@nl

P1433

Q37384874-9C75084E-D230-4F0A-888B-66B494D765B4

P1476

Q37384874-2444E46F-D905-4E88-A96E-5C2519CB9F74

P2093

Q37384874-0D0818D0-3E98-4B45-BD4F-F3706224BFE9

Q37384874-2328537B-5564-414D-9E98-B11BAEE898B3

Q37384874-39D67222-A75B-4B4C-A2C2-0D1E588B477C

Q37384874-814202A8-479D-476C-8669-9EE9FA8194A0

Q37384874-8D6B9F6B-BF0C-434C-B16F-4D0E77FBC91C

Q37384874-8D73C1CE-0E5C-45B1-9EDE-D0B59CB9B320

Q37384874-BFAC1C1B-E39B-4286-8EF9-38610CDE8A65

Q37384874-E15A1B27-5322-46AC-B2D9-7D0AA87B6513

Q37384874-E5DC466B-BB83-47F7-B76E-E7FA2BE9FBF6

P2860

Q37384874-06DFA8E0-DF93-4330-9011-FFE76099B871

Q37384874-182E1C9B-6715-409D-82AE-6D7F5BB4E61A

Q37384874-1F5D7624-4C2A-4FFD-BB13-8E7C446879FE

Q37384874-2B24731C-D874-46FA-94D4-20F9372052DC

Q37384874-32291DAA-8BB8-4677-8BF9-22708B4A7480

Q37384874-34E471C8-FB1C-4150-A5FF-8F155A8893B6

Q37384874-3585CDAF-9D90-417A-8DC4-D93D87B19104

Q37384874-38B813B8-87DC-47CE-91EF-D2053BDBF75D

Q37384874-3C6FC688-1B32-4AA6-B92C-3A1207FE2FCB

Q37384874-415BB24B-2CCE-4894-8072-087DE5DE873B

P304

Q37384874-CDB395EE-EE56-4B86-9A2B-854F801B2269

P31

Q37384874-7E49BCDB-9225-4AF2-8B0F-04A5FA66F31C

P356

Q37384874-9A0C5905-962F-44C4-A1D3-F71D166803DD

P407

Q37384874-551DB195-52DF-403A-9DE3-690DC58735DB

P433

Q37384874-09A8828C-E995-49A7-BA57-466DEAB2061D

P478

Q37384874-43722DA0-027A-4863-8790-79B4309E0E2D

P50

Q37384874-75518E1C-FDAF-49A6-988B-4FB7E2CA46A5

P577

Q37384874-225A706F-1985-4702-B94E-56CE5BA567E9

P5875

Q37384874-4AC2542A-0F06-47E8-83B2-27E8D6EDAD1E

P698

Q37384874-5A63651E-6EBC-43D9-A220-BC71D5AE7B92

P921

Q37384874-80219454-A095-4CF2-ACCB-F334D8D8C4E7

P932

Q37384874-831D8A61-1A51-438D-9E94-1E3EAD326B37

P356

0008-5472.CAN-07-6867

P1433

Cancer Research

P1476

Pten haploinsufficiency accelerates formation of high-grade astrocytomas

@en

P2093

Chang-Hyuk Kwon

http://www.w3.org/2001/XMLSchema#string

Dawen Zhao

http://www.w3.org/2001/XMLSchema#string

Dennis K Burns

http://www.w3.org/2001/XMLSchema#string

Eva Y-H P Lee

http://www.w3.org/2001/XMLSchema#string

Hong Wu

http://www.w3.org/2001/XMLSchema#string

Jian Chen

http://www.w3.org/2001/XMLSchema#string

Luis F Parada

http://www.w3.org/2001/XMLSchema#string

Sheila Alcantara

http://www.w3.org/2001/XMLSchema#string

Yanjiao Li

http://www.w3.org/2001/XMLSchema#string

P2860

ROS fusion tyrosine kinase activates a SH2 domain-containing phosphatase-2/phosphatidylinositol 3-kinase/mammalian target of rapamycin signaling axis to form glioblastoma in mice

The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate

Cancerous stem cells can arise from pediatric brain tumors

Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma

Identification of a cancer stem cell in human brain tumors

Subventricular zone astrocytes are neural stem cells in the adult mammalian brain

Doublecortin is a microtubule-associated protein and is expressed widely by migrating neurons

PTEN tumor suppressor regulates p53 protein levels and activity through phosphatase-dependent and -independent mechanisms

Human cortical glial tumors contain neural stem-like cells expressing astroglial and neuronal markers in vitro

Pten is essential for embryonic development and tumour suppression

P304

3286-3294

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1158/0008-5472.CAN-07-6867

http://www.w3.org/2001/XMLSchema#string

P407

P433

9

http://www.w3.org/2001/XMLSchema#string

P478

68

http://www.w3.org/2001/XMLSchema#string

P50

P577

2008-05-01T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

5401795

http://www.w3.org/2001/XMLSchema#string

P698

18451155

http://www.w3.org/2001/XMLSchema#string

P921

haploinsufficiency

P932

2760841

http://www.w3.org/2001/XMLSchema#string