A role for the SHP-2 tyrosine phosphatase in nerve growth-induced PC12 cell differentiation.
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Binding of Shp2 tyrosine phosphatase to FRS2 is essential for fibroblast growth factor-induced PC12 cell differentiationNeurotrophins: roles in neuronal development and functionThe signaling adapter FRS-2 competes with Shc for binding to the nerve growth factor receptor TrkA. A model for discriminating proliferation and differentiationDifferential regulation of leukemia inhibitory factor-stimulated neuronal gene expression by protein phosphatases SHP-1 and SHP-2 through mitogen-activated protein kinase-dependent and -independent pathwaysIdentification of SNT/FRS2 docking site on RET receptor tyrosine kinase and its role for signal transductionMultiple effector domains within SNT1 coordinate ERK activation and neuronal differentiation of PC12 cellsPhosphotyrosine 1173 mediates binding of the protein-tyrosine phosphatase SHP-1 to the epidermal growth factor receptor and attenuation of receptor signalingDownregulation of LAR tyrosine phosphatase prevents apoptosis and augments NGF-induced neurite outgrowthSHP-2 mediates target-regulated axonal termination and NGF-dependent neurite growth in sympathetic neuronsThe neurite outgrowth multiadaptor RhoGAP, NOMA-GAP, regulates neurite extension through SHP2 and Cdc42Differentiation of neuroblastoma cell line N1E-115 involves several signaling cascades.Cardiovascular actions of neurotrophinsSHP2 positively regulates TGFβ1-induced epithelial-mesenchymal transition modulated by its novel interacting protein Hook1.You can't go home again: transcriptionally driven alteration of cell signaling by NGF.Morphogenetic movements at gastrulation require the SH2 tyrosine phosphatase Shp2.SHP-2 deletion in postmigratory neural crest cells results in impaired cardiac sympathetic innervation.Neurite Outgrowth in PC12 Cells Stimulated by Components from Dendranthema × grandiflorum cv. "Mottenohoka" Is Enhanced by Suppressing Phosphorylation of p38MAPK.Reactive oxygen species, Ki-Ras, and mitochondrial superoxide dismutase cooperate in nerve growth factor-induced differentiation of PC12 cellsAcidic substitution of the activation loop tyrosines in TrkA supports nerve growth factor-independent cell survival and neuronal differentiation.SHP-1 negatively regulates neuronal survival by functioning as a TrkA phosphataseShp-2 positively regulates brain-derived neurotrophic factor-promoted survival of cultured ventral mesencephalic dopaminergic neurons through a brain immunoglobulin-like molecule with tyrosine-based activation motifs/Shp substrate-1.Neurite outgrowth of PC12 cells by 4'-O-β-D-glucopyranosyl-3',4-dimethoxychalcone from Brassica rapa L. 'hidabeni' was enhanced by pretreatment with p38MAPK inhibitor.Noonan syndrome type I with PTPN11 3 bp deletion: structure-function implications.Csk-homologous kinase interacts with SHPS-1 and enhances neurite outgrowth of PC12 cells.The protein tyrosine phosphatase, Shp2, is required for the complete activation of the RAS/MAPK pathway by brain-derived neurotrophic factor.
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P2860
A role for the SHP-2 tyrosine phosphatase in nerve growth-induced PC12 cell differentiation.
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article científic
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article scientifique
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articolo scientifico
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artigo científico
@pt
bilimsel makale
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scientific article published on August 1997
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
A role for the SHP-2 tyrosine ...... ced PC12 cell differentiation.
@en
A role for the SHP-2 tyrosine ...... ced PC12 cell differentiation.
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type
label
A role for the SHP-2 tyrosine ...... ced PC12 cell differentiation.
@en
A role for the SHP-2 tyrosine ...... ced PC12 cell differentiation.
@nl
prefLabel
A role for the SHP-2 tyrosine ...... ced PC12 cell differentiation.
@en
A role for the SHP-2 tyrosine ...... ced PC12 cell differentiation.
@nl
P2093
P2860
P356
P1476
A role for the SHP-2 tyrosine ...... ced PC12 cell differentiation.
@en
P2093
P2860
P304
P356
10.1091/MBC.8.8.1575
P577
1997-08-01T00:00:00Z