The signaling adapter FRS-2 competes with Shc for binding to the nerve growth factor receptor TrkA. A model for discriminating proliferation and differentiation
about
Role and expression of FRS2 and FRS3 in prostate cancerUse of signal specific receptor tyrosine kinase oncoproteins reveals that pathways downstream from Grb2 or Shc are sufficient for cell transformation and metastasisIdentification of a switch in neurotrophin signaling by selective tyrosine phosphorylationRap1GAP interacts with RET and suppresses GDNF-induced neurite outgrowthDocking protein FRS2 links the protein tyrosine kinase RET and its oncogenic forms with the mitogen-activated protein kinase signaling cascadeFRS2 proteins recruit intracellular signaling pathways by binding to diverse targets on fibroblast growth factor and nerve growth factor receptorsA unique pathway for sustained neurotrophin signaling through an ankyrin-rich membrane-spanning proteinStimulation of phosphatidylinositol 3-kinase by fibroblast growth factor receptors is mediated by coordinated recruitment of multiple docking proteinsBiological activity of the thyroid TRK-T3 oncogene requires signalling through ShcNeurotrophins: roles in neuronal development and functionNeurotrophin-regulated signalling pathwaysNovel p62dok family members, dok-4 and dok-5, are substrates of the c-Ret receptor tyrosine kinase and mediate neuronal differentiationNerve growth factor stimulates multisite tyrosine phosphorylation and activation of the atypical protein kinase C's via a src kinase pathway.Structural basis of SNT PTB domain interactions with distinct neurotrophic receptorsStructural insights into FRS2α PTB domain recognition by neurotrophin receptor TrkBDirect interaction of nerve growth factor receptor, TrkA, with non-receptor tyrosine kinase, c-Abl, through the activation loopDirect binding of the signaling adapter protein Grb2 to the activation loop tyrosines on the nerve growth factor receptor tyrosine kinase, TrkAAssociation of the Abl tyrosine kinase with the Trk nerve growth factor receptorIdentification of SNT/FRS2 docking site on RET receptor tyrosine kinase and its role for signal transductionAssociation of the atypical protein kinase C-interacting protein p62/ZIP with nerve growth factor receptor TrkA regulates receptor trafficking and Erk5 signalingShcB and ShcC activation by the Trk family of receptor tyrosine kinasesThe PTB domain of ShcA couples receptor activation to the cytoskeletal regulator IQGAP1Phosphorylation of c-Crk II on the negative regulatory Tyr222 mediates nerve growth factor-induced cell spreading and morphogenesisCoupling of Gab1 to c-Met, Grb2, and Shp2 mediates biological responsesThe long coiled-coil protein NECC2 is associated to caveolae and modulates NGF/TrkA signaling in PC12 cells [corrected]ALK activation induces Shc and FRS2 recruitment: Signaling and phenotypic outcomes in PC12 cells differentiationInteraction of Mint2 with TrkA is involved in regulation of nerve growth factor-induced neurite outgrowthFrs2α enhances fibroblast growth factor-mediated survival and differentiation in lens developmentMolecular networks in FGF signaling: flotillin-1 and cbl-associated protein compete for the binding to fibroblast growth factor receptor substrate 2Nesca, a novel adapter, translocates to the nuclear envelope and regulates neurotrophin-induced neurite outgrowth.Neurite growth promotion by nerve growth factor and insulin-like growth factor-1 in cultured adult sensory neurons: role of phosphoinositide 3-kinase and mitogen activated protein kinase.Screening for PTB domain binding partners and ligand specificity using proteome-derived NPXY peptide arrays.Neurotrophin-dependent tyrosine phosphorylation of Ras guanine-releasing factor 1 and associated neurite outgrowth is dependent on the HIKE domain of TrkA.Downstream of tyrosine kinase/docking protein 6, as a novel substrate of tropomyosin-related kinase C receptor, is involved in neurotrophin 3-mediated neurite outgrowth in mouse cortex neurons.Cardiovascular actions of neurotrophinsDistinct recruitment and function of Gab1 and Gab2 in Met receptor-mediated epithelial morphogenesis.Identification of the mechanisms regulating the differential activation of the mapk cascade by epidermal growth factor and nerve growth factor in PC12 cells.Role of phosphoinositide 3-kinase and endocytosis in nerve growth factor-induced extracellular signal-regulated kinase activation via Ras and Rap1.p75 neurotrophin receptor signaling: mechanisms for neurotrophic modulation of cell stress?The heparan sulfate co-receptor and the concentration of fibroblast growth factor-2 independently elicit different signalling patterns from the fibroblast growth factor receptor.
P2860
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P2860
The signaling adapter FRS-2 competes with Shc for binding to the nerve growth factor receptor TrkA. A model for discriminating proliferation and differentiation
description
1999 nî lūn-bûn
@nan
1999 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
1999 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
1999年の論文
@ja
1999年論文
@yue
1999年論文
@zh-hant
1999年論文
@zh-hk
1999年論文
@zh-mo
1999年論文
@zh-tw
1999年论文
@wuu
name
The signaling adapter FRS-2 co ...... liferation and differentiation
@ast
The signaling adapter FRS-2 co ...... liferation and differentiation
@en
The signaling adapter FRS-2 co ...... liferation and differentiation
@nl
type
label
The signaling adapter FRS-2 co ...... liferation and differentiation
@ast
The signaling adapter FRS-2 co ...... liferation and differentiation
@en
The signaling adapter FRS-2 co ...... liferation and differentiation
@nl
prefLabel
The signaling adapter FRS-2 co ...... liferation and differentiation
@ast
The signaling adapter FRS-2 co ...... liferation and differentiation
@en
The signaling adapter FRS-2 co ...... liferation and differentiation
@nl
P2093
P2860
P356
P1476
The signaling adapter FRS-2 co ...... liferation and differentiation
@en
P2093
P2860
P304
P356
10.1074/JBC.274.14.9861
P407
P577
1999-04-02T00:00:00Z