Inhibition of mitochondrial pyruvate transport by zaprinast causes massive accumulation of aspartate at the expense of glutamate in the retina
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Mitochondrial pyruvate transport: a historical perspective and future research directionsMetabolomics analysis of metabolic effects of nicotinamide phosphoribosyltransferase (NAMPT) inhibition on human cancer cellsThe retinal pigment epithelium utilizes fatty acids for ketogenesis.Regulation of substrate utilization by the mitochondrial pyruvate carrierMetabolic plasticity maintains proliferation in pyruvate dehydrogenase deficient cellsPhototransduction Influences Metabolic Flux and Nucleotide Metabolism in Mouse RetinaQuantification of Low-Level Drug Effects Using Real-Time, in vitro Measurement of Oxygen Consumption Rate.Deficient glucose and glutamine metabolism in Aralar/AGC1/Slc25a12 knockout mice contributes to altered visual functionReductive carboxylation is a major metabolic pathway in the retinal pigment epithelium.Loss of Mitochondrial Pyruvate Carrier 2 in the Liver Leads to Defects in Gluconeogenesis and Compensation via Pyruvate-Alanine Cycling.Glutamine oxidation maintains the TCA cycle and cell survival during impaired mitochondrial pyruvate transport.Knockout of PARG110 confers resistance to cGMP-induced toxicity in mammalian photoreceptorsBiochemical adaptations of the retina and retinal pigment epithelium support a metabolic ecosystem in the vertebrate eye.Inhibition of the mitochondrial pyruvate carrier protects from excitotoxic neuronal death.Glymphatic clearance controls state-dependent changes in brain lactate concentration.Compartmentalized activities of the pyruvate dehydrogenase complex sustain lipogenesis in prostate cancer.Interruption of lactate uptake by inhibiting mitochondrial pyruvate transport unravels direct antitumor and radiosensitizing effects.Targeting energy metabolism via the mitochondrial pyruvate carrier as a novel approach to attenuate neurodegeneration.Function of mitochondrial pyruvate carriers in hepatocellular carcinoma patients.
P2860
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P2860
Inhibition of mitochondrial pyruvate transport by zaprinast causes massive accumulation of aspartate at the expense of glutamate in the retina
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name
Inhibition of mitochondrial py ...... nse of glutamate in the retina
@en
Inhibition of mitochondrial py ...... se of glutamate in the retina.
@nl
type
label
Inhibition of mitochondrial py ...... nse of glutamate in the retina
@en
Inhibition of mitochondrial py ...... se of glutamate in the retina.
@nl
prefLabel
Inhibition of mitochondrial py ...... nse of glutamate in the retina
@en
Inhibition of mitochondrial py ...... se of glutamate in the retina.
@nl
P2093
P2860
P50
P356
P1476
Inhibition of mitochondrial py ...... nse of glutamate in the retina
@en
P2093
Andrei O Chertov
Austin M Rountree
Ayse Sahaboglu
Ian R Sweet
James B Hurley
Jianhai Du
Jonathan Linton
Ken Lindsay
Martin Sadilek
Sally J Turner
P2860
P304
36129-36140
P356
10.1074/JBC.M113.507285
P407
P577
2013-11-01T00:00:00Z