EPAC proteins transduce diverse cellular actions of cAMP.
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Interaction with receptor for activated C-kinase 1 (RACK1) sensitizes the phosphodiesterase PDE4D5 towards hydrolysis of cAMP and activation by protein kinase CRole of guanine-nucleotide exchange factor Epac in renal physiology and pathophysiologyProtein kinase A acts at the basal body of the primary cilium to prevent Gli2 activation and ventralization of the mouse neural tubeMultiple treatments with L-3,4-dihydroxyphenylalanine modulate dopamine biosynthesis and neurotoxicity through the protein kinase A-transient extracellular signal-regulated kinase and exchange protein activation by cyclic AMP-sustained extracellularRecent advances in the discovery of small molecules targeting exchange proteins directly activated by cAMP (EPAC).Differential inhibitory effects of CysLT(1) receptor antagonists on P2Y(6) receptor-mediated signaling and ion transport in human bronchial epithelia.ACTH induces Cav3.2 current and mRNA by cAMP-dependent and cAMP-independent mechanisms.Autocrine prostaglandin E2 signaling promotes tumor cell survival and proliferation in childhood neuroblastoma.Type 10 soluble adenylyl cyclase is overexpressed in prostate carcinoma and controls proliferation of prostate cancer cellsPDE2 is a novel target for attenuating tumor formation in a mouse model of UVB-induced skin carcinogenesisIdentification of the Raf-1 signaling pathway used by cAMP to inhibit p42/p44 MAPK in rat lacrimal gland acini: role in potentiation of protein secretion.A selective phosphodiesterase-4 inhibitor reduces leukocyte infiltration, oxidative processes, and tissue damage after spinal cord injury.Rap1GAP impairs cell-matrix adhesion in the absence of effects on cell-cell adhesionA universal stress protein (USP) in mycobacteria binds cAMP.Abnormal activity of the MAPK- and cAMP-associated signaling pathways in frontal cortical areas in postmortem brain in schizophrenia.cAMP-mediated secretion of brain-derived neurotrophic factor in developing airway smooth muscle.Phosphodiesterase 4D acts downstream of Neuropilin to control Hedgehog signal transduction and the growth of medulloblastomaHeat-labile enterotoxin-induced activation of NF-κB and MAPK pathways in intestinal epithelial cells impacts enterotoxigenic Escherichia coli (ETEC) adherence.cAMP Promotes Cell Migration Through Cell Junctional Complex Dynamics and Actin Cytoskeleton Remodeling: Implications in Skin Wound HealingIdentification of a Novel, Small Molecule Partial Agonist for the Cyclic AMP Sensor, EPAC1.Structure, functional regulation and signaling properties of Rap2B.Functional chromaffin cell plasticity in response to stress: focus on nicotinic, gap junction, and voltage-gated Ca2+ channels.G protein-coupled estrogen receptor inhibits the P2Y receptor-mediated Ca(2+) signaling pathway in human airway epithelia.Regulation of G-protein signaling via Gnas is required to regulate proximal tubular growth in the Xenopus pronephros.The fundamental unit of pain is the cell.Epac1 interacts with importin β1 and controls neurite outgrowth independently of cAMP and Rap1.The adenylyl cyclase activity of anthrax edema factor.The role of Epac proteins, novel cAMP mediators, in the regulation of immune, lung and neuronal function.The role of cyclic nucleotide signaling pathways in cancer: targets for prevention and treatmentEmerging themes of cAMP regulation of the pulmonary endothelial barrier.Ezrin, Radixin and Moesin: key regulators of membrane-cortex interactions and signalingNovel cAMP signalling paradigms: therapeutic implications for airway diseaseCyclic nucleotide phosphodiesterase (PDE) isozymes as targets of the intracellular signalling network: benefits of PDE inhibitors in various diseases and perspectives for future therapeutic developments.Regulation of the inflammatory response of vascular endothelial cells by EPAC1.Role of Epac in brain and heart.cAMP regulation of airway smooth muscle function.New methods for the discovery and synthesis of PDE7 inhibitors as new drugs for neurological and inflammatory disorders.New perspectives in cyclic nucleotide-mediated functions in the CNS: the emerging role of cyclic nucleotide-gated (CNG) channels.Multiple facets of cAMP signalling and physiological impact: cAMP compartmentalization in the lung.T-type channel-mediated neurotransmitter release.
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P2860
EPAC proteins transduce diverse cellular actions of cAMP.
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
@pt
bilimsel makale
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scientific article published on 06 February 2009
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
EPAC proteins transduce diverse cellular actions of cAMP.
@en
EPAC proteins transduce diverse cellular actions of cAMP.
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type
label
EPAC proteins transduce diverse cellular actions of cAMP.
@en
EPAC proteins transduce diverse cellular actions of cAMP.
@nl
prefLabel
EPAC proteins transduce diverse cellular actions of cAMP.
@en
EPAC proteins transduce diverse cellular actions of cAMP.
@nl
P2093
P2860
P1476
EPAC proteins transduce diverse cellular actions of cAMP.
@en
P2093
Brian O Smith
Gillian Borland
Stephen J Yarwood
P2860
P356
10.1111/J.1476-5381.2008.00087.X
P407
P577
2009-02-06T00:00:00Z